C1r (complement C1r) - Rat Genome Database

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Gene: C1r (complement C1r) Heterocephalus glaber
Analyze
Symbol: C1r
Name: complement C1r
RGD ID: 18933516
Description: ENCODES a protein that exhibits identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN complement activation (inferred); complement activation, classical pathway (inferred); innate immune response (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); Ehlers-Danlos syndrome (ortholog); Ehlers-Danlos syndrome periodontal type 1 (ortholog); FOUND IN blood microparticle (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: complement C1r subcomponent
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,676,252 - 3,684,406 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,675,926 - 3,684,598 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
C1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,676,252 - 3,684,406 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,675,926 - 3,684,598 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
C1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,080,219 - 7,092,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,080,214 - 7,092,540 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,187,523 - 7,245,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,132,347 - 7,136,184 (-)NCBINCBI36Build 36hg18NCBI36
Build 36127,057,768 - 7,058,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,132,345 - 7,136,184NCBI
Celera128,810,415 - 8,821,122 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,051,362 - 7,057,949 (-)NCBIHuRef
HuRef127,047,821 - 7,049,720 (-)NCBIHuRef
CHM1_1127,186,493 - 7,188,392 (-)NCBICHM1_1
CHM1_1127,240,180 - 7,244,018 (-)NCBICHM1_1
T2T-CHM13v2.0127,093,689 - 7,105,531 (-)NCBIT2T-CHM13v2.0
C1rb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,547,389 - 124,558,003 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,547,253 - 124,558,130 (+)EnsemblGRCm39 Ensembl
GRCm386124,570,430 - 124,581,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,570,294 - 124,581,171 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,520,448 - 124,531,062 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,535,681 - 124,546,793 (+)NCBIMGSCv36mm8
Celera6126,253,012 - 126,262,880 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
C1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,099,013 - 159,109,770 (+)NCBIGRCr8
mRatBN7.24157,412,718 - 157,423,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,412,692 - 157,423,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,635,374 - 163,646,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,418,283 - 159,429,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,064,480 - 158,075,420 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,126,060 - 157,136,825 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,125,998 - 157,136,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,144,564 - 224,155,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,712,582 - 160,729,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,957,464 - 160,974,090 (+)NCBI
Celera4146,152,622 - 146,163,370 (+)NCBICelera
Cytogenetic Map4q42NCBI
C1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,652,308 - 4,660,304 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,652,156 - 4,660,897 (-)NCBIChiLan1.0ChiLan1.0
C1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,646,068 - 12,658,919 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,642,630 - 12,654,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,211,162 - 7,222,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,126,723 - 7,137,895 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,126,723 - 7,137,895 (-)Ensemblpanpan1.1panPan2
C1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,951,137 - 37,960,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,950,246 - 37,960,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,656,115 - 8,665,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,303,593 - 38,313,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,303,136 - 38,333,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,178,473 - 38,188,007 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,219,555 - 38,229,110 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,134,262 - 8,143,646 (-)NCBIUU_Cfam_GSD_1.0
C1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,041,423 - 102,052,228 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709708,968 - 720,478 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709709,001 - 719,758 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,643,374 - 63,655,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,644,097 - 63,655,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,115,964 - 7,134,612 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,125,367 - 7,134,758 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,078,052 - 1,089,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001949   ⟹   ENSHGLP00000001903
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248603,676,252 - 3,684,406 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001950   ⟹   ENSHGLP00000001904
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248603,676,252 - 3,684,040 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001951   ⟹   ENSHGLP00000001905
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248603,680,555 - 3,684,066 (-)Ensembl
RefSeq Acc Id: XM_013067292   ⟹   XP_012922746
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248603,675,926 - 3,684,598 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012922746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001903
  ENSHGLP00100044364
GenBank Protein JAO03422 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012922746   ⟸   XM_013067292
- UniProtKB: A0A0N8EUZ4 (UniProtKB/TrEMBL),   G5CAS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001904   ⟸   ENSHGLT00000001950
RefSeq Acc Id: ENSHGLP00000001905   ⟸   ENSHGLT00000001951
RefSeq Acc Id: ENSHGLP00000001903   ⟸   ENSHGLT00000001949


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001453 Ensembl, ENTREZGENE
  ENSHGLG00100015509 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001949 ENTREZGENE
  ENSHGLT00100080858 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report hgl:101717538 UniProtKB/TrEMBL
NCBI Gene C1r ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/TrEMBL
  PTHR24255:SF25 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF C1r_C1s_MASP UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49854 UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A0N8EUZ4 ENTREZGENE, UniProtKB/TrEMBL
  G5CAS6 ENTREZGENE, UniProtKB/TrEMBL