Isca1 (iron-sulfur cluster assembly 1) - Rat Genome Database

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Gene: Isca1 (iron-sulfur cluster assembly 1) Heterocephalus glaber
Analyze
Symbol: Isca1
Name: iron-sulfur cluster assembly 1
RGD ID: 18930368
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); iron-sulfur cluster binding (inferred); INVOLVED IN iron-sulfur cluster assembly (inferred); protein maturation by iron-sulfur cluster transfer (inferred); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH genetic disease (ortholog); multiple mitochondrial dysfunctions syndrome (ortholog); multiple mitochondrial dysfunctions syndrome 5 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: iron-sulfur cluster assembly 1 homolog; iron-sulfur cluster assembly 1 homolog, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480911,099,485 - 11,114,917 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480911,099,483 - 11,114,917 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
mitochondrion  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Isca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480911,099,485 - 11,114,917 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480911,099,483 - 11,114,917 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ISCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38986,264,546 - 86,282,538 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl986,264,546 - 86,283,102 (-)EnsemblGRCh38hg38GRCh38
GRCh37988,879,461 - 88,897,453 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36988,069,281 - 88,087,310 (-)NCBINCBI36Build 36hg18NCBI36
Build 34986,109,015 - 86,127,044NCBI
Celera959,449,572 - 59,467,604 (-)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef958,702,212 - 58,720,322 (-)NCBIHuRef
CHM1_1989,025,905 - 89,043,932 (-)NCBICHM1_1
T2T-CHM13v2.0998,415,772 - 98,433,767 (-)NCBIT2T-CHM13v2.0
Isca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391359,903,229 - 59,917,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1359,903,223 - 59,917,624 (-)EnsemblGRCm39 Ensembl
GRCm381359,755,415 - 59,769,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1359,755,409 - 59,769,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv371359,856,776 - 59,871,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361359,765,038 - 59,779,412 (-)NCBIMGSCv36mm8
Celera1360,813,565 - 60,829,332 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.88NCBI
Isca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,910,816 - 4,923,478 (+)NCBIGRCr8
mRatBN7.2174,905,291 - 4,917,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,905,287 - 4,917,955 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,924,890 - 4,937,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0176,466,859 - 6,479,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0174,921,330 - 4,934,105 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0175,281,727 - 5,294,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,281,727 - 5,294,384 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,507,069 - 7,519,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41710,808,966 - 10,821,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11710,808,965 - 10,821,679 (+)NCBI
Celera175,026,823 - 5,039,495 (+)NCBICelera
Cytogenetic Map17p14NCBI
Isca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554321,335,481 - 1,349,847 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554321,335,481 - 1,349,852 (+)NCBIChiLan1.0ChiLan1.0
ISCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21153,120,297 - 53,141,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1953,125,609 - 53,143,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0957,410,328 - 57,428,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1985,467,139 - 85,485,107 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl985,467,145 - 85,485,107 (-)Ensemblpanpan1.1panPan2
Isca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947120,048,452 - 120,064,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366801,673,666 - 1,689,635 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366801,673,666 - 1,689,646 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1029,066,178 - 29,080,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11029,066,135 - 29,082,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21033,108,940 - 33,123,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ISCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11296,900,619 - 96,915,611 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1296,897,849 - 96,915,540 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603885,250,660 - 85,266,902 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000010614   ⟹   ENSHGLP00000010497
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480911,099,485 - 11,114,917 (+)Ensembl
RefSeq Acc Id: XM_004862467   ⟹   XP_004862524
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480911,099,483 - 11,114,917 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862524 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000010497
GenBank Protein JAO01699 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004862524   ⟸   XM_004862467
- UniProtKB: A0A0P6JBL3 (UniProtKB/TrEMBL),   G5ARL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000010497   ⟸   ENSHGLT00000010614


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007531 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010614 ENTREZGENE
Gene3D-CATH 2.60.300.12 UniProtKB/TrEMBL
InterPro FeS_biogenesis UniProtKB/TrEMBL
  FeS_cluster_insertion UniProtKB/TrEMBL
  FeS_cluster_insertion_CS UniProtKB/TrEMBL
  HesB-like_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101697806 UniProtKB/TrEMBL
NCBI Gene Isca1 ENTREZGENE
PANTHER IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  IRON-SULFUR CLUSTER ASSEMBLY PROTEIN UniProtKB/TrEMBL
Pfam Fe-S_biosyn UniProtKB/TrEMBL
PROSITE HESB UniProtKB/TrEMBL
Superfamily-SCOP SSF89360 UniProtKB/TrEMBL
UniProt A0A0P6JBL3 ENTREZGENE, UniProtKB/TrEMBL
  G5ARL7 ENTREZGENE, UniProtKB/TrEMBL