Tcirg1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) - Rat Genome Database

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Gene: Tcirg1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) Heterocephalus glaber
Analyze
Symbol: Tcirg1
Name: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
RGD ID: 18929796
Description: ENCODES a protein that exhibits ATPase binding (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN apoptotic process (ortholog); autophagosome assembly (ortholog); autophagy (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal recessive osteopetrosis 1 (ortholog); choreaacanthocytosis (ortholog); FOUND IN apical plasma membrane (inferred); late endosome (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: V-type proton ATPase 116 kDa subunit a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,809,689 - 18,820,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,809,626 - 18,820,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
autophagosome assembly  (IEA,ISO)
autophagy  (IEA,ISO)
B cell differentiation  (IEA,ISO)
bone resorption  (IEA,ISO)
cellular response to cytokine stimulus  (IEA,ISO)
dentin mineralization  (IEA,ISO)
enamel mineralization  (IEA,ISO)
establishment of cell polarity  (IEA,ISO)
establishment of vesicle localization  (IEA,ISO)
gene expression  (IEA,ISO)
hematopoietic stem cell homeostasis  (IEA,ISO)
homeostasis of number of cells  (IEA,ISO)
immunoglobulin mediated immune response  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular pH reduction  (IEA,ISO)
macroautophagy  (IEA,ISO)
memory T cell activation  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
odontogenesis  (IEA,ISO)
optic nerve development  (IEA,ISO)
ossification  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
osteoclast proliferation  (IEA,ISO)
pH reduction  (IEA,ISO)
phagosome acidification  (IEA,ISO)
protein catabolic process in the vacuole  (IEA,ISO)
protein localization to organelle  (IEA,ISO)
proton transmembrane transport  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of osteoblast differentiation  (IEA,ISO)
regulation of proton transport  (IEA,ISO)
response to silver ion  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
ruffle organization  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T-helper 1 cell activation  (IEA,ISO)
tooth eruption  (IEA,ISO)
vacuolar acidification  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tcirg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,809,689 - 18,820,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,809,626 - 18,820,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TCIRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,039,025 - 68,053,762 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,039,025 - 68,050,895 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,806,492 - 67,818,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,563,059 - 67,574,942 (+)NCBINCBI36Build 36hg18NCBI36
Celera1165,140,155 - 65,152,040 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,141,805 - 64,153,709 (+)NCBIHuRef
CHM1_11167,690,218 - 67,702,120 (+)NCBICHM1_1
T2T-CHM13v2.01168,042,666 - 68,057,403 (+)NCBIT2T-CHM13v2.0
Tcirg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,946,050 - 3,957,717 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,946,050 - 3,957,133 (-)EnsemblGRCm39 Ensembl
GRCm38193,896,050 - 3,907,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,896,050 - 3,907,133 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,896,050 - 3,907,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,896,053 - 3,905,230 (-)NCBIMGSCv36mm8
Celera193,776,425 - 3,787,508 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.62NCBI
Tcirg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,556,270 - 210,568,021 (-)NCBIGRCr8
mRatBN7.21201,127,034 - 201,138,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,127,034 - 201,138,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,500,301 - 209,509,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,589,084 - 216,598,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,263,286 - 209,272,675 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,126,687 - 219,139,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,127,602 - 219,139,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,999,292 - 226,012,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,420,106 - 206,429,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,573,497 - 206,585,222 (-)NCBI
Celera1198,679,648 - 198,689,037 (-)NCBICelera
Cytogenetic Map1q43NCBI
Tcirg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,768,469 - 17,779,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,768,469 - 17,778,976 (-)NCBIChiLan1.0ChiLan1.0
TCIRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,989,593 - 69,001,506 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,032,855 - 70,044,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,120,913 - 63,132,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,429,435 - 66,441,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,429,435 - 66,441,327 (+)Ensemblpanpan1.1panPan2
TCIRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,784,480 - 49,794,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,784,490 - 49,794,317 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,393,818 - 48,403,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,705,711 - 50,715,580 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,703,574 - 50,715,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,919,281 - 49,929,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,494,101 - 49,503,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,287,643 - 50,297,518 (-)NCBIUU_Cfam_GSD_1.0
Tcirg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,627,790 - 5,636,842 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,066,847 - 2,079,206 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,070,211 - 2,079,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCIRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,844,637 - 4,860,498 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,844,627 - 4,860,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,476,372 - 3,488,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCIRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,484,469 - 6,497,008 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,484,474 - 6,494,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,762,696 - 103,775,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026074   ⟹   ENSHGLP00000025845
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476718,809,689 - 18,820,390 (-)Ensembl
RefSeq Acc Id: XM_004852199   ⟹   XP_004852256
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,809,626 - 18,820,325 (-)NCBI
RefSeq Acc Id: XM_013074711   ⟹   XP_012930165
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,809,626 - 18,819,649 (-)NCBI
RefSeq Acc Id: XM_021264485   ⟹   XP_021120144
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,809,626 - 18,818,670 (-)NCBI
RefSeq Acc Id: XM_021264486   ⟹   XP_021120145
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,809,626 - 18,818,670 (-)NCBI
RefSeq Acc Id: XM_021264487   ⟹   XP_021120146
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,809,626 - 18,820,360 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021120146   ⟸   XM_021264487
- Peptide Label: isoform X3
- UniProtKB: G5BTV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852256   ⟸   XM_004852199
- Peptide Label: isoform X3
- UniProtKB: G5BTV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012930165   ⟸   XM_013074711
- Peptide Label: isoform X3
- UniProtKB: G5BTV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120145   ⟸   XM_021264486
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021120144   ⟸   XM_021264485
- Peptide Label: isoform X1
RefSeq Acc Id: ENSHGLP00000025845   ⟸   ENSHGLT00000026074


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018395 Ensembl, ENTREZGENE
  ENSHGLG00100014181 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026074 ENTREZGENE
  ENSHGLT00100019437 UniProtKB/TrEMBL
InterPro V-ATPase_116kDa_su UniProtKB/TrEMBL
  V-type_ATPase_116kDa_su_euka UniProtKB/TrEMBL
KEGG Report hgl:101720677 UniProtKB/TrEMBL
NCBI Gene Tcirg1 ENTREZGENE
PANTHER PTHR11629 UniProtKB/TrEMBL
  V-TYPE PROTON ATPASE 116 KDA SUBUNIT A3 UniProtKB/TrEMBL
Pfam V_ATPase_I UniProtKB/TrEMBL
PIRSF ATP6V0A1 UniProtKB/TrEMBL
UniProt G5BTV6 ENTREZGENE, UniProtKB/TrEMBL