Mfsd8 (major facilitator superfamily domain containing 8) - Rat Genome Database

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Gene: Mfsd8 (major facilitator superfamily domain containing 8) Heterocephalus glaber
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Symbol: Mfsd8
Name: major facilitator superfamily domain containing 8
RGD ID: 18927147
Description: ENCODES a protein that exhibits chloride channel activity (ortholog); fluoride channel activity (ortholog); iodide transmembrane transporter activity (ortholog); INVOLVED IN apoptotic process (ortholog); astrocyte differentiation (ortholog); autophagosome maturation (ortholog); ASSOCIATED WITH cone-rod dystrophy (ortholog); epilepsy (ortholog); fundus dystrophy (ortholog); FOUND IN endosome membrane (ortholog); lysosome (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: major facilitator superfamily domain-containing protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,827,851 - 8,877,873 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247778,831,246 - 8,877,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mfsd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,827,851 - 8,877,873 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247778,831,246 - 8,877,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MFSD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384127,917,732 - 127,965,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4127,917,799 - 127,966,034 (-)EnsemblGRCh38hg38GRCh38
GRCh374128,838,887 - 128,887,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,061,027 - 129,106,554 (-)NCBINCBI36Build 36hg18NCBI36
Celera4126,217,913 - 126,268,512 (-)NCBICelera
Cytogenetic Map4q28.2NCBI
HuRef4124,566,671 - 124,619,214 (-)NCBIHuRef
CHM1_14128,815,418 - 128,863,591 (-)NCBICHM1_1
T2T-CHM13v2.04131,220,758 - 131,270,005 (-)NCBIT2T-CHM13v2.0
Mfsd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,772,500 - 40,801,322 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,772,538 - 40,801,321 (-)EnsemblGRCm39 Ensembl
GRCm38340,818,065 - 40,846,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,818,103 - 40,846,886 (-)EnsemblGRCm38mm10GRCm38
MGSCv37340,622,094 - 40,650,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36340,914,721 - 40,943,403 (-)NCBIMGSCv36mm8
Celera340,547,784 - 40,576,409 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.55NCBI
Mfsd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,749,994 - 125,784,689 (-)NCBIGRCr8
mRatBN7.22123,822,042 - 123,847,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,816,614 - 123,857,971 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2130,392,521 - 130,418,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,504,953 - 128,530,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,134,093 - 123,159,861 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,706,618 - 127,784,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,699,761 - 127,781,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02147,311,814 - 147,387,510 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42127,782,871 - 127,833,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12127,732,787 - 127,757,121 (-)NCBI
Celera2118,732,091 - 118,791,325 (-)NCBICelera
Cytogenetic Map2q26NCBI
Mfsd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,519,277 - 13,544,695 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542813,519,285 - 13,548,007 (+)NCBIChiLan1.0ChiLan1.0
MFSD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23125,687,213 - 125,735,779 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14125,953,454 - 126,002,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04120,087,477 - 120,137,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14131,391,361 - 131,439,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,391,361 - 131,439,590 (-)Ensemblpanpan1.1panPan2
MFSD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11912,905,336 - 13,030,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1912,982,394 - 13,020,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1913,094,242 - 13,219,682 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01912,995,177 - 13,120,933 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1913,072,372 - 13,110,059 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11912,968,213 - 13,093,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,253,606 - 13,379,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,716,168 - 13,841,616 (+)NCBIUU_Cfam_GSD_1.0
Mfsd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,453,182 - 61,542,477 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,801,908 - 2,832,830 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366422,745,889 - 2,833,286 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,925,081 - 96,972,383 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1896,925,063 - 96,972,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,791,981 - 103,839,336 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFSD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,043,740 - 75,096,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,046,545 - 75,072,258 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603754,178,730 - 54,235,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000016338   ⟹   ENSHGLP00000016169
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247778,827,851 - 8,877,873 (-)Ensembl
RefSeq Acc Id: XM_004854957   ⟹   XP_004855014
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,877,881 (-)NCBI
RefSeq Acc Id: XM_004854958   ⟹   XP_004855015
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,875,290 (-)NCBI
RefSeq Acc Id: XM_013075906   ⟹   XP_012931360
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,875,290 (-)NCBI
RefSeq Acc Id: XM_021236476   ⟹   XP_021092135
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,877,729 (-)NCBI
RefSeq Acc Id: XM_021236477   ⟹   XP_021092136
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,865,847 (-)NCBI
RefSeq Acc Id: XM_021236478   ⟹   XP_021092137
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,875,290 (-)NCBI
RefSeq Acc Id: XM_021236479   ⟹   XP_021092138
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247778,831,246 - 8,864,361 (-)NCBI
RefSeq Acc Id: XP_004855014   ⟸   XM_004854957
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JCC9 (UniProtKB/TrEMBL),   G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092135   ⟸   XM_021236476
- Peptide Label: isoform X2
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931360   ⟸   XM_013075906
- Peptide Label: isoform X4
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004855015   ⟸   XM_004854958
- Peptide Label: isoform X4
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092137   ⟸   XM_021236478
- Peptide Label: isoform X4
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092136   ⟸   XM_021236477
- Peptide Label: isoform X3
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092138   ⟸   XM_021236479
- Peptide Label: isoform X4
- UniProtKB: G5AKY6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016169   ⟸   ENSHGLT00000016338


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011574 Ensembl, ENTREZGENE
  ENSHGLG00000037009 UniProtKB/TrEMBL
  ENSHGLG00100051554 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000016338 ENTREZGENE
  ENSHGLT00000058603 UniProtKB/TrEMBL
  ENSHGLT00000068833 UniProtKB/TrEMBL
  ENSHGLT00100081658 UniProtKB/TrEMBL
  ENSHGLT00100089153 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_Domain-Containing_Protein UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
KEGG Report hgl:101699855 UniProtKB/TrEMBL
NCBI Gene Mfsd8 ENTREZGENE
PANTHER INNER MEMBRANE TRANSPORT PROTEIN YAJR UniProtKB/TrEMBL
  MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A0P6JCC9 ENTREZGENE, UniProtKB/TrEMBL
  G5AKY6 ENTREZGENE, UniProtKB/TrEMBL