Nploc4 (NPL4 homolog, ubiquitin recognition factor) - Rat Genome Database

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Gene: Nploc4 (NPL4 homolog, ubiquitin recognition factor) Heterocephalus glaber
Analyze
Symbol: Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
RGD ID: 18927078
Description: ENCODES a protein that exhibits ATPase binding (ortholog); K48-linked polyubiquitin modification-dependent protein binding (ortholog); K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN Golgi organization (ortholog); negative regulation of RIG-I signaling pathway (ortholog); negative regulation of type I interferon production (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN UFD1-NPL4 complex (ortholog); VCP-NPL4-UFD1 AAA ATPase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear protein localization protein 4 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,533,064 - 10,589,096 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,531,107 - 10,589,502 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nploc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,533,064 - 10,589,096 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,531,107 - 10,589,502 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NPLOC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,556,885 - 81,637,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,556,887 - 81,648,465 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,523,911 - 79,604,138 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,134,357 - 77,214,543 (-)NCBINCBI36Build 36hg18NCBI36
Build 341777,134,358 - 77,214,493NCBI
Celera1776,168,272 - 76,249,182 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1774,971,514 - 75,050,623 (-)NCBIHuRef
CHM1_11779,610,124 - 79,690,039 (-)NCBICHM1_1
T2T-CHM13v2.01782,474,164 - 82,554,047 (-)NCBIT2T-CHM13v2.0
Nploc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,270,624 - 120,328,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,271,196 - 120,328,534 (-)EnsemblGRCm39 Ensembl
GRCm3811120,379,798 - 120,437,700 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,380,370 - 120,437,708 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,241,685 - 120,298,982 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,196,461 - 120,253,758 (-)NCBIMGSCv36mm8
Celera11132,115,124 - 132,172,461 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.09NCBI
Nploc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,152,756 - 106,208,306 (-)NCBIGRCr8
mRatBN7.210105,654,395 - 105,709,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,654,812 - 105,709,913 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,759,179 - 110,814,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,222,198 - 110,277,289 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,575,294 - 105,630,381 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,553,518 - 109,610,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,552,649 - 109,610,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,148,086 - 109,198,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,809,121 - 109,878,278 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,825,236 - 109,862,213 (-)NCBI
Celera10104,200,159 - 104,255,207 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Nploc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,451,337 - 1,513,455 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,451,337 - 1,513,455 (+)NCBIChiLan1.0ChiLan1.0
NPLOC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,143,491 - 98,223,643 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,043,770 - 103,123,943 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,012,756 - 76,092,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,713,582 - 81,785,567 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,713,582 - 81,788,714 (-)Ensemblpanpan1.1panPan2
NPLOC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19538,087 - 604,898 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9537,840 - 603,480 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,142,086 - 1,207,840 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,133,445 - 1,199,269 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,131,519 - 1,198,105 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,158,270 - 1,223,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,284,872 - 1,349,805 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,363,947 - 1,429,700 (+)NCBIUU_Cfam_GSD_1.0
Nploc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,158,248 - 1,205,737 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,205,659 - 5,251,026 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,206,222 - 5,251,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPLOC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,251,053 - 1,285,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,251,377 - 1,285,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,102,565 - 1,128,796 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPLOC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,499,737 - 73,570,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,502,123 - 73,570,710 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607744,881,353 - 44,976,051 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000021411   ⟹   ENSHGLP00000021207
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480110,533,064 - 10,589,096 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000021412   ⟹   ENSHGLP00000021208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480110,533,302 - 10,589,048 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000021413   ⟹   ENSHGLP00000021209
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480110,533,302 - 10,583,902 (-)Ensembl
RefSeq Acc Id: XM_004860934   ⟹   XP_004860991
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,531,107 - 10,589,290 (-)NCBI
RefSeq Acc Id: XM_021241332   ⟹   XP_021096991
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,531,107 - 10,589,502 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004860991 (Get FASTA)   NCBI Sequence Viewer  
  XP_021096991 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021207
  ENSHGLP00100008859
GenBank Protein JAN97260 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021096991   ⟸   XM_021241332
- Peptide Label: isoform X2
- UniProtKB: G5BFG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004860991   ⟸   XM_004860934
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J208 (UniProtKB/TrEMBL),   G5BFG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000021208   ⟸   ENSHGLT00000021412
RefSeq Acc Id: ENSHGLP00000021207   ⟸   ENSHGLT00000021411
RefSeq Acc Id: ENSHGLP00000021209   ⟸   ENSHGLT00000021413


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015156 Ensembl, ENTREZGENE
  ENSHGLG00100006592 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000021411 ENTREZGENE
  ENSHGLT00100008963 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro MPN UniProtKB/TrEMBL
  Npl4 UniProtKB/TrEMBL
  NPL4_C UniProtKB/TrEMBL
  Npl4_Ub-like_dom UniProtKB/TrEMBL
  NPL4_Zn-bd_put UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
KEGG Report hgl:101704760 UniProtKB/TrEMBL
NCBI Gene Nploc4 ENTREZGENE
PANTHER NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG UniProtKB/TrEMBL
  PTHR12710 UniProtKB/TrEMBL
Pfam NPL4 UniProtKB/TrEMBL
  UN_NPL4 UniProtKB/TrEMBL
  zf-NPL4 UniProtKB/TrEMBL
PIRSF Polyub_prc_Npl4 UniProtKB/TrEMBL
PROSITE MPN UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
SMART ZnF_RBZ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A0P6J208 ENTREZGENE, UniProtKB/TrEMBL
  G5BFG0 ENTREZGENE, UniProtKB/TrEMBL