Snta1 (syntrophin alpha 1) - Rat Genome Database

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Gene: Snta1 (syntrophin alpha 1) Heterocephalus glaber
Analyze
Symbol: Snta1
Name: syntrophin alpha 1
RGD ID: 18926075
Description: ENCODES a protein that exhibits ATPase binding (ortholog); nitric-oxide synthase binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN negative regulation of peptidyl-cysteine S-nitrosylation (ortholog); neuromuscular junction development (ortholog); regulation of heart rate (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); Becker muscular dystrophy (ortholog); Brugada syndrome (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic membrane (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Alpha-1-syntrophin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,805,342 - 5,834,022 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,805,409 - 5,834,553 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
fosphenytoin pharmacokinetics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Snta1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,805,342 - 5,834,022 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,805,409 - 5,834,553 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SNTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,407,957 - 33,443,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,407,957 - 33,443,763 (-)EnsemblGRCh38hg38GRCh38
GRCh372031,995,763 - 32,031,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,459,424 - 31,495,359 (-)NCBINCBI36Build 36hg18NCBI36
Build 342031,459,423 - 31,495,359NCBI
Celera2028,749,527 - 28,785,451 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,783,561 - 28,819,451 (-)NCBIHuRef
CHM1_12031,896,842 - 31,932,765 (-)NCBICHM1_1
T2T-CHM13v2.02035,135,186 - 35,170,977 (-)NCBIT2T-CHM13v2.0
Snta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,218,234 - 154,250,004 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,218,233 - 154,250,019 (-)EnsemblGRCm39 Ensembl
GRCm382154,376,313 - 154,408,107 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,376,313 - 154,408,099 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,202,050 - 154,233,820 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,067,769 - 154,099,522 (-)NCBIMGSCv36mm8
Celera2160,280,592 - 160,313,658 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.52NCBI
Snta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,336,509 - 163,366,954 (-)NCBIGRCr8
mRatBN7.23142,876,285 - 142,906,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,876,296 - 142,906,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,743,646 - 146,773,763 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,361,813 - 155,391,929 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,101,175 - 153,131,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,874,023 - 149,905,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,874,030 - 149,905,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,245,190 - 156,278,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,843,678 - 144,874,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,749,301 - 144,779,860 (-)NCBI
Celera3141,611,616 - 141,641,783 (-)NCBICelera
Cytogenetic Map3q41NCBI
Snta1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,844,853 - 27,871,547 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,844,699 - 27,872,104 (+)NCBIChiLan1.0ChiLan1.0
SNTA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,099,698 - 39,135,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,092,798 - 39,128,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,696,137 - 29,732,258 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,810,787 - 30,844,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,810,787 - 30,844,476 (-)Ensemblpanpan1.1panPan2
SNTA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,636,716 - 22,665,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,636,756 - 22,665,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,281,583 - 22,313,637 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,322,134 - 23,354,134 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,322,133 - 23,354,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,597,383 - 22,628,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,708,067 - 22,740,033 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,139,650 - 23,170,903 (-)NCBIUU_Cfam_GSD_1.0
Snta1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,615,021 - 171,653,713 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365617,101,654 - 7,133,988 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365617,101,654 - 7,134,529 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5RAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,915,953 - 36,946,187 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11736,917,276 - 36,946,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,867,614 - 41,896,571 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNTA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,703,002 - 37,737,529 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,702,971 - 37,737,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605089,152,431 - 89,194,359 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000009262   ⟹   ENSHGLP00000009163
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248425,805,342 - 5,834,022 (+)Ensembl
RefSeq Acc Id: XM_004867942   ⟹   XP_004867999
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248425,805,409 - 5,834,553 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004867999 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB11307 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009163
  ENSHGLP00100001812
RefSeq Acc Id: XP_004867999   ⟸   XM_004867942
- UniProtKB: G5BPU9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000009163   ⟸   ENSHGLT00000009262


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006583 Ensembl, ENTREZGENE
  ENSHGLG00100001410 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000009262 ENTREZGENE
  ENSHGLT00100001852 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PHsplit_syntrophin UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
KEGG Report hgl:101721241 UniProtKB/TrEMBL
NCBI Gene Snta1 ENTREZGENE
PANTHER PTHR10554 UniProtKB/TrEMBL
  PTHR10554:SF6 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PH_17 UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt G5BPU9 ENTREZGENE, UniProtKB/TrEMBL