LOC101702367 (DNA topoisomerase 2-alpha) - Rat Genome Database

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Gene: LOC101702367 (DNA topoisomerase 2-alpha) Heterocephalus glaber
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Symbol: LOC101702367 (Ensembl: TOP2A)
Name: DNA topoisomerase 2-alpha
RGD ID: 18924703
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA negative supercoiling activity (inferred); INVOLVED IN apoptotic chromosome condensation (inferred); DNA topological change (inferred); resolution of meiotic recombination intermediates (inferred); FOUND IN cytoplasm (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,898,038 - 2,926,049 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,903,686 - 2,927,028 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018145   ⟹   ENSHGLP00000017968
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247952,898,038 - 2,926,049 (+)Ensembl
RefSeq Acc Id: XM_021240035   ⟹   XP_021095694
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247952,903,687 - 2,927,028 (+)NCBI
RefSeq Acc Id: XM_021240036   ⟹   XP_021095695
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247952,903,687 - 2,927,028 (+)NCBI
RefSeq Acc Id: XM_021240037   ⟹   XP_021095696
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247952,903,687 - 2,927,028 (+)NCBI
RefSeq Acc Id: XM_021240038   ⟹   XP_021095697
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247952,903,686 - 2,927,028 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021095694 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095695 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095696 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095697 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017968
RefSeq Acc Id: XP_021095697   ⟸   XM_021240038
- Peptide Label: isoform X2
- UniProtKB: G5AX78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095694   ⟸   XM_021240035
- Peptide Label: isoform X1
- UniProtKB: G5AX78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095695   ⟸   XM_021240036
- Peptide Label: isoform X1
- UniProtKB: G5AX78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095696   ⟸   XM_021240037
- Peptide Label: isoform X1
- UniProtKB: G5AX78 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017968   ⟸   ENSHGLT00000018145


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012875 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018145 ENTREZGENE
Gene3D-CATH 3.30.1360.40 UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/TrEMBL
  Histidine kinase-like ATPase, C-terminal domain UniProtKB/TrEMBL
  Topoisomerase II, domain 5 UniProtKB/TrEMBL
  Topoisomerase, domain 3 UniProtKB/TrEMBL
InterPro DNA_Topoisomerase_II UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_C UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Topo_IIA UniProtKB/TrEMBL
  Topo_IIA-like_dom_sf UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/TrEMBL
  Topo_IIA_A_a_sf UniProtKB/TrEMBL
  Topo_IIA_B_C UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/TrEMBL
  Topo_IIA_dom_A UniProtKB/TrEMBL
  TopoII_euk UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/TrEMBL
NCBI Gene LOC101702367 ENTREZGENE
PANTHER DNA TOPOISOMERASE 2-ALPHA UniProtKB/TrEMBL
  DNA TOPOISOMERASE/GYRASE UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
PRINTS TOPISMRASEII UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_II UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
SMART TOP2c UniProtKB/TrEMBL
  TOP4c UniProtKB/TrEMBL
Superfamily-SCOP ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase UniProtKB/TrEMBL
  Ribosomal protein S5 domain 2-like UniProtKB/TrEMBL
  Type II DNA topoisomerase UniProtKB/TrEMBL
UniProt A0AAX6RDA3_HETGA UniProtKB/TrEMBL
  A0AAX6RH50_HETGA UniProtKB/TrEMBL
  G5AX78 ENTREZGENE, UniProtKB/TrEMBL