Pcsk2 (proprotein convertase subtilisin/kexin type 2) - Rat Genome Database

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Gene: Pcsk2 (proprotein convertase subtilisin/kexin type 2) Heterocephalus glaber
Analyze
Symbol: Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
RGD ID: 18923572
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN enkephalin processing (ortholog); insulin processing (ortholog); islet amyloid polypeptide processing (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH cataract 33 (ortholog); chronic kidney disease (ortholog); Endotoxemia (ortholog); FOUND IN dendrite (ortholog); intracellular membrane-bounded organelle (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuroendocrine convertase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474118,368,928 - 18,643,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474118,368,976 - 18,643,151 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway   (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pcsk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474118,368,928 - 18,643,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474118,368,976 - 18,643,151 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PCSK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382017,226,107 - 17,484,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2017,226,107 - 17,484,578 (+)EnsemblGRCh38hg38GRCh38
GRCh372017,206,752 - 17,465,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,155,631 - 17,413,223 (+)NCBINCBI36Build 36hg18NCBI36
Build 342017,155,630 - 17,413,223NCBI
Celera2017,282,082 - 17,539,671 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2017,169,857 - 17,428,162 (+)NCBIHuRef
CHM1_12017,206,780 - 17,465,251 (+)NCBICHM1_1
T2T-CHM13v2.02017,276,847 - 17,535,278 (+)NCBIT2T-CHM13v2.0
Pcsk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392143,388,053 - 143,658,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2143,388,076 - 143,658,205 (+)EnsemblGRCm39 Ensembl
GRCm382143,546,133 - 143,816,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2143,546,156 - 143,816,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv372143,371,869 - 143,642,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362143,237,620 - 143,507,725 (+)NCBIMGSCv36mm8
Celera2144,735,342 - 144,999,086 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map270.89NCBI
Pcsk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83151,333,938 - 151,636,628 (+)NCBIGRCr8
mRatBN7.23130,880,422 - 131,183,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3130,880,422 - 131,183,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3134,802,865 - 135,106,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03143,386,914 - 143,690,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03141,090,099 - 141,394,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
RH 3.4 Map31176.7RGD
Cytogenetic Map3q41NCBI
Pcsk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541526,266,484 - 26,497,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541526,266,513 - 26,496,905 (+)NCBIChiLan1.0ChiLan1.0
PCSK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,114,726 - 18,371,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12018,111,564 - 18,367,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02017,184,878 - 17,443,355 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12017,163,675 - 17,421,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2017,163,675 - 17,421,157 (+)Ensemblpanpan1.1panPan2
PCSK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,507,997 - 5,765,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,508,714 - 5,766,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha245,440,841 - 5,698,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0245,915,819 - 6,173,890 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,915,828 - 6,173,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,528,990 - 5,786,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,622,926 - 5,880,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0245,898,980 - 6,157,570 (-)NCBIUU_Cfam_GSD_1.0
Pcsk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640154,177,620 - 154,434,915 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364852,608,353 - 2,866,294 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364852,611,313 - 2,866,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1725,681,197 - 25,923,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11725,681,424 - 25,920,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21729,095,048 - 29,329,854 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1246,293,983 - 46,548,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl246,294,005 - 46,549,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666078961,154 - 1,215,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004840850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01019469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01004221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000013983   ⟹   ENSHGLP00000013842
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474118,368,928 - 18,643,600 (+)Ensembl
RefSeq Acc Id: XM_004840850   ⟹   XP_004840907
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474118,368,976 - 18,643,151 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004840907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000013842
  ENSHGLP00100008520
GenBank Protein JAN99411 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004840907   ⟸   XM_004840850
- UniProtKB: A0A0P6J508 (UniProtKB/TrEMBL),   G5CB99 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000013842   ⟸   ENSHGLT00000013983


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009894 Ensembl, ENTREZGENE
  ENSHGLG00100006349 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000013983 ENTREZGENE
  ENSHGLT00100008621 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro Galactose-bd-like_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report hgl:101710029 UniProtKB/TrEMBL
NCBI Gene Pcsk2 ENTREZGENE
PANTHER NEUROENDOCRINE CONVERTASE 2 UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
UniProt A0A0P6J508 ENTREZGENE, UniProtKB/TrEMBL
  G5CB99 ENTREZGENE, UniProtKB/TrEMBL