Spo11 (SPO11 initiator of meiotic double strand breaks) - Rat Genome Database

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Gene: Spo11 (SPO11 initiator of meiotic double strand breaks) Heterocephalus glaber
Analyze
Symbol: Spo11
Name: SPO11 initiator of meiotic double strand breaks (Ensembl:SPO11 initiator of meiotic double stranded breaks)
RGD ID: 18923369
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA topoisomerase activity (inferred); INVOLVED IN double-strand break repair involved in meiotic recombination (ortholog); homologous chromosome pairing at meiosis (ortholog); male meiosis I (ortholog); ASSOCIATED WITH spermatogenic failure 3 (ortholog); FOUND IN chromosome, telomeric region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Meiotic recombination protein SPO11; SPO11 initiator of meiotic double stranded breaks
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474123,784,298 - 23,800,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474123,784,362 - 23,800,127 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474123,784,298 - 23,800,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474123,784,362 - 23,800,127 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382057,329,803 - 57,343,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2057,329,803 - 57,343,994 (+)EnsemblGRCh38hg38GRCh38
GRCh372055,904,859 - 55,919,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,338,238 - 55,352,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 342055,338,237 - 55,352,455NCBI
Celera2052,645,068 - 52,659,286 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2052,686,790 - 52,701,008 (+)NCBIHuRef
CHM1_12055,805,942 - 55,820,160 (+)NCBICHM1_1
T2T-CHM13v2.02059,107,550 - 59,121,740 (+)NCBIT2T-CHM13v2.0
Spo11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,819,172 - 172,835,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,819,493 - 172,835,369 (+)EnsemblGRCm39 Ensembl
GRCm382172,977,379 - 172,993,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,977,700 - 172,993,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,805,343 - 172,819,077 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,622,784 - 172,636,504 (+)NCBIMGSCv36mm8
MGSCv362174,209,775 - 174,223,792 (+)NCBIMGSCv36mm8
Celera2178,918,642 - 178,957,539 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.64NCBI
Spo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,173,615 - 182,189,273 (+)NCBIGRCr8
mRatBN7.23161,755,299 - 161,770,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,571,645 - 165,582,906 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,070,591 - 174,081,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,812,404 - 171,823,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,991,573 - 171,008,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,058,150 - 177,081,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,842,817 - 163,854,067 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,746,748 - 163,759,641 (+)NCBI
Celera3160,953,190 - 160,964,440 (+)NCBICelera
Cytogenetic Map3q42NCBI
Spo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,088,144 - 2,103,385 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,088,144 - 2,103,385 (-)NCBIChiLan1.0ChiLan1.0
SPO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,080,959 - 63,095,174 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12063,074,078 - 63,088,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02053,669,128 - 53,684,328 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,948,664 - 54,962,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,948,661 - 54,963,384 (+)Ensemblpanpan1.1panPan2
SPO11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,345,595 - 42,360,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,345,547 - 42,384,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,593,229 - 41,608,456 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02443,211,094 - 43,226,379 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2443,211,048 - 43,250,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12442,296,075 - 42,311,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02442,435,814 - 42,451,039 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02443,093,993 - 43,109,232 (+)NCBIUU_Cfam_GSD_1.0
Spo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,108,577 - 183,122,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936530183,271 - 197,335 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936530183,271 - 197,549 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPO11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,730,675 - 57,745,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,730,676 - 57,745,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,894,962 - 64,910,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,778,442 - 6,792,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl26,778,985 - 6,792,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605054,840,590 - 54,854,921 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007765   ⟹   ENSHGLP00000007679
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474123,784,298 - 23,800,168 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007766   ⟹   ENSHGLP00000007680
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474123,784,436 - 23,799,372 (+)Ensembl
RefSeq Acc Id: XM_004840923   ⟹   XP_004840980
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474123,784,362 - 23,800,125 (+)NCBI
RefSeq Acc Id: XM_021255153   ⟹   XP_021110812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474123,784,362 - 23,800,125 (+)NCBI
RefSeq Acc Id: XM_021255154   ⟹   XP_021110813
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474123,784,362 - 23,800,127 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004840980 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110812 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007679
GenBank Protein JAN97958 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021110813   ⟸   XM_021255154
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021110812   ⟸   XM_021255153
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004840980   ⟸   XM_004840923
- Peptide Label: isoform X2
- UniProtKB: G5AUN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007680   ⟸   ENSHGLT00000007766
Ensembl Acc Id: ENSHGLP00000007679   ⟸   ENSHGLT00000007765


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005570 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007765 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  3.40.1360.10 UniProtKB/TrEMBL
InterPro Meiosis_Spo11 UniProtKB/TrEMBL
  Meiotic_Spo11 UniProtKB/TrEMBL
  Spo11/TopoVI_A UniProtKB/TrEMBL
  Spo11/TopoVI_A_N UniProtKB/TrEMBL
  Spo11/TopoVI_A_sf UniProtKB/TrEMBL
  TOPRIM_Topo6A/Spo11 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report hgl:101706565 UniProtKB/TrEMBL
NCBI Gene Spo11 ENTREZGENE
PANTHER MEIOTIC RECOMBINATION PROTEIN SPO11 UniProtKB/TrEMBL
  PTHR10848 UniProtKB/TrEMBL
Pfam SPO11_like UniProtKB/TrEMBL
  TOP6A-Spo11_Toprim UniProtKB/TrEMBL
  TP6A_N UniProtKB/TrEMBL
PRINTS SPO11HOMOLOG UniProtKB/TrEMBL
  TOP6AFAMILY UniProtKB/TrEMBL
Superfamily-SCOP SSF56726 UniProtKB/TrEMBL
UniProt A0AAX6SQP3_HETGA UniProtKB/TrEMBL
  A0AAX6SS33_HETGA UniProtKB/TrEMBL
  G5AUN1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-24 Spo11  SPO11 initiator of meiotic double strand breaks  Spo11  SPO11 initiator of meiotic double stranded breaks  Symbol and/or name change 5135510 APPROVED