Kat5 (lysine acetyltransferase 5) - Rat Genome Database

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Gene: Kat5 (lysine acetyltransferase 5) Heterocephalus glaber
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Symbol: Kat5
Name: lysine acetyltransferase 5
RGD ID: 18923153
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); histone H2A acetyltransferase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to estradiol stimulus (ortholog); cellular response to glucose starvation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INO80 family mediated chromatin remodeling pathway; ASSOCIATED WITH Aicardi-Goutieres syndrome (ortholog); Aicardi-Goutieres Syndrome 3 (ortholog); B-cell lymphoma (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Histone acetyltransferase KAT5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,666,763 - 20,675,164 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,668,759 - 20,675,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to X-ray  (ISO)
chromatin remodeling  (IEA)
DNA damage response  (IEA)
DNA damage response, signal transduction by p53 class mediator  (ISO)
DNA repair  (IEA)
DNA repair-dependent chromatin remodeling  (ISO)
double-strand break repair  (ISO)
double-strand break repair via homologous recombination  (IEA)
establishment of mitotic spindle orientation  (ISO)
lipid droplet disassembly  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of double-strand break repair via homologous recombination  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube development  (ISO)
neurogenesis  (ISO)
nucleotide-excision repair  (ISO)
peptidyl-lysine acetylation  (ISO)
positive regulation of aggrephagy  (ISO)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of circadian rhythm  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of double-strand break repair via homologous recombination  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of mitotic sister chromatid segregation  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein acetylation  (ISO)
protein modification process  (ISO)
regulation of cell cycle  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of hematopoietic stem cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to ionizing radiation  (ISO)
sperm DNA condensation  (ISO)
spermatid development  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Kat5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,666,763 - 20,675,164 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,668,759 - 20,675,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KAT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,712,018 - 65,719,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,711,996 - 65,719,604 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,479,723 - 65,487,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,236,065 - 65,243,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,236,064 - 65,243,650NCBI
Celera1162,806,503 - 62,814,088 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,806,327 - 61,813,930 (+)NCBIHuRef
CHM1_11165,363,389 - 65,370,993 (+)NCBICHM1_1
T2T-CHM13v2.01165,706,411 - 65,713,762 (+)NCBIT2T-CHM13v2.0
Kat5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,653,042 - 5,661,584 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,653,042 - 5,660,265 (-)EnsemblGRCm39 Ensembl
GRCm38195,603,014 - 5,611,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,603,014 - 5,610,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,603,418 - 5,610,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,603,418 - 5,610,029 (-)NCBIMGSCv36mm8
Celera195,473,388 - 5,479,999 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Kat5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,325,089 - 212,332,640 (-)NCBIGRCr8
mRatBN7.21202,895,751 - 202,903,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,895,751 - 202,903,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,248,063 - 211,255,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,341,145 - 218,348,449 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,032,196 - 211,039,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,967,795 - 220,974,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,967,796 - 220,974,597 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,898,843 - 227,906,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,233,434 - 208,240,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,387,311 - 208,393,493 (-)NCBI
Celera1200,431,510 - 200,438,814 (-)NCBICelera
Cytogenetic Map1q43NCBI
Kat5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,557,498 - 19,565,036 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,557,498 - 19,565,044 (-)NCBIChiLan1.0ChiLan1.0
KAT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,917,509 - 66,949,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,960,283 - 67,992,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,071,118 - 61,078,667 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,405,088 - 64,412,667 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,404,572 - 64,412,667 (+)Ensemblpanpan1.1panPan2
KAT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,499,615 - 51,507,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,499,938 - 51,576,699 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,108,124 - 50,115,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,537,753 - 52,545,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,537,754 - 52,545,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,637,256 - 51,645,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,211,884 - 51,219,692 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,001,339 - 52,009,137 (-)NCBIUU_Cfam_GSD_1.0
Kat5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,325,177 - 7,332,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,766,242 - 3,776,128 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,767,526 - 3,775,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,560,513 - 6,572,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,560,544 - 6,572,461 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,668,370 - 5,676,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KAT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,528,097 - 8,544,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,526,788 - 8,544,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,821,178 - 105,829,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000013525   ⟹   ENSHGLP00000013385
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476720,666,763 - 20,675,134 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000013526   ⟹   ENSHGLP00000013386
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476720,666,763 - 20,675,134 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000013527   ⟹   ENSHGLP00000013387
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476720,669,097 - 20,675,164 (-)Ensembl
RefSeq Acc Id: XM_004852377   ⟹   XP_004852434
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,365 (-)NCBI
RefSeq Acc Id: XM_004852378   ⟹   XP_004852435
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,364 (-)NCBI
RefSeq Acc Id: XM_004852379   ⟹   XP_004852436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,365 (-)NCBI
RefSeq Acc Id: XM_004852380   ⟹   XP_004852437
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,364 (-)NCBI
RefSeq Acc Id: XM_013074962   ⟹   XP_012930416
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,365 (-)NCBI
RefSeq Acc Id: XM_021264576   ⟹   XP_021120235
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,366 (-)NCBI
RefSeq Acc Id: XM_021264577   ⟹   XP_021120236
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,367 (-)NCBI
RefSeq Acc Id: XM_021264578   ⟹   XP_021120237
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476720,668,759 - 20,675,367 (-)NCBI
RefSeq Acc Id: XP_021120237   ⟸   XM_021264578
- Peptide Label: isoform X8
- UniProtKB: A0AAX6TD09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120236   ⟸   XM_021264577
- Peptide Label: isoform X5
- UniProtKB: A0AAX6TGH8 (UniProtKB/TrEMBL),   G5B6J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120235   ⟸   XM_021264576
- Peptide Label: isoform X1
- UniProtKB: A0AAX6TK44 (UniProtKB/TrEMBL),   G5B6J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012930416   ⟸   XM_013074962
- Peptide Label: isoform X3
- UniProtKB: A0AAX6R1R7 (UniProtKB/TrEMBL),   A0A0P6JBT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852436   ⟸   XM_004852379
- Peptide Label: isoform X6
- UniProtKB: A0AAX6PI17 (UniProtKB/TrEMBL),   G5B6J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852434   ⟸   XM_004852377
- Peptide Label: isoform X2
- UniProtKB: A0AAX6PII9 (UniProtKB/TrEMBL),   G5B6J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852437   ⟸   XM_004852380
- Peptide Label: isoform X7
- UniProtKB: A0AAX6PI30 (UniProtKB/TrEMBL),   A0A0P6JBT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852435   ⟸   XM_004852378
- Peptide Label: isoform X4
- UniProtKB: A0AAX6PIJ1 (UniProtKB/TrEMBL),   A0A0P6JBT9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000013387   ⟸   ENSHGLT00000013527
Ensembl Acc Id: ENSHGLP00000013385   ⟸   ENSHGLT00000013525
Ensembl Acc Id: ENSHGLP00000013386   ⟸   ENSHGLT00000013526


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009569 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000013525 ENTREZGENE
  ENSHGLT00000013526 ENTREZGENE
  ENSHGLT00000013527 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/TrEMBL
  N-acetyl transferase-like UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/TrEMBL
  HAT_MYST-type UniProtKB/TrEMBL
  MYST_HAT UniProtKB/TrEMBL
  Tudor-knot UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  Zf-MYST UniProtKB/TrEMBL
NCBI Gene Kat5 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE UniProtKB/TrEMBL
  HISTONE ACETYLTRANSFERASE KAT5 UniProtKB/TrEMBL
Pfam MOZ_SAS UniProtKB/TrEMBL
  Tudor-knot UniProtKB/TrEMBL
  zf-MYST UniProtKB/TrEMBL
PROSITE MYST_HAT UniProtKB/TrEMBL
SMART CHROMO UniProtKB/TrEMBL
Superfamily-SCOP SSF54160 UniProtKB/TrEMBL
  SSF55729 UniProtKB/TrEMBL
UniProt A0A0P6JBT9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PI17 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PI30 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PII9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PIJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R1R7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TD09 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TGH8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TK44 ENTREZGENE, UniProtKB/TrEMBL
  G5B6J4 ENTREZGENE, UniProtKB/TrEMBL