Rubcn (rubicon autophagy regulator) - Rat Genome Database

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Gene: Rubcn (rubicon autophagy regulator) Heterocephalus glaber
Analyze
Symbol: Rubcn
Name: rubicon autophagy regulator
RGD ID: 18922999
Description: ENCODES a protein that exhibits phosphatidylinositol 3-kinase inhibitor activity (ortholog); INVOLVED IN negative regulation of autophagy (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 15 (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RUN and cysteine rich domain containing beclin 1 interacting protein; run domain Beclin-1-interacting and cysteine-rich domain-containing protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,040,857 - 61,112,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,040,848 - 61,111,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Rubcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,040,857 - 61,112,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,040,848 - 61,111,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RUBCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,668,867 - 197,749,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3197,668,867 - 197,749,727 (-)EnsemblGRCh38hg38GRCh38
GRCh373197,395,738 - 197,476,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,882,656 - 198,948,170 (-)NCBINCBI36Build 36hg18NCBI36
Celera3196,014,953 - 196,093,675 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3194,700,863 - 194,779,394 (-)NCBIHuRef
CHM1_13197,369,082 - 197,447,450 (-)NCBICHM1_1
T2T-CHM13v2.03200,401,254 - 200,482,196 (-)NCBIT2T-CHM13v2.0
Rubcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,642,072 - 32,698,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,642,073 - 32,698,136 (-)EnsemblGRCm39 Ensembl
GRCm381632,821,702 - 32,877,729 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,821,703 - 32,877,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,790,776 - 32,868,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,821,822 - 32,868,425 (-)NCBIMGSCv36mm8
Celera1633,300,516 - 33,347,564 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.38NCBI
Rubcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,420,261 - 81,469,415 (+)NCBIGRCr8
mRatBN7.21167,907,534 - 67,964,347 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,907,516 - 67,964,314 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01171,150,506 - 71,199,254 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,151,132 - 71,197,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,228,171 - 74,284,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,735,303 - 69,784,725 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,791,474 - 69,840,095 (+)NCBI
Celera1167,351,336 - 67,408,299 (+)NCBICelera
Cytogenetic Map11q22NCBI
Rubcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,123,450 - 12,187,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,124,193 - 12,187,154 (+)NCBIChiLan1.0ChiLan1.0
RUBCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22195,582,351 - 195,663,052 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13195,590,157 - 195,671,134 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03195,088,936 - 195,166,771 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13204,974,746 - 205,049,871 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,973,968 - 205,034,011 (-)Ensemblpanpan1.1panPan2
RUBCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13328,947,439 - 29,011,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3328,946,944 - 29,009,346 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3328,968,568 - 29,032,995 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,178,166 - 29,242,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,178,166 - 29,243,273 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13328,974,845 - 29,039,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,021,133 - 29,085,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,641,226 - 29,705,388 (+)NCBIUU_Cfam_GSD_1.0
Rubcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,447,313 - 125,515,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784383,899 - 438,275 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784370,173 - 438,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUBCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13134,299,152 - 134,353,374 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113134,299,971 - 134,363,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,893,948 - 143,947,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RUBCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,401,565 - 91,468,837 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,400,031 - 91,457,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604165,343,040 - 65,400,021 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000024277   ⟹   ENSHGLP00000024058
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,040,857 - 61,112,926 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000024278   ⟹   ENSHGLP00000024059
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,050,623 - 61,112,926 (+)Ensembl
RefSeq Acc Id: XM_004834671   ⟹   XP_004834728
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,040,848 - 61,111,998 (+)NCBI
RefSeq Acc Id: XM_004834672   ⟹   XP_004834729
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,050,684 - 61,111,998 (+)NCBI
RefSeq Acc Id: XM_004834673   ⟹   XP_004834730
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,040,849 - 61,111,998 (+)NCBI
RefSeq Acc Id: XM_021254864   ⟹   XP_021110523
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,069,826 - 61,111,998 (+)NCBI
RefSeq Acc Id: XM_021254865   ⟹   XP_021110524
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,051,017 - 61,111,998 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004834728   ⟸   XM_004834671
- Peptide Label: isoform X1
- UniProtKB: G5ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834730   ⟸   XM_004834673
- Peptide Label: isoform X3
- UniProtKB: G5ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834729   ⟸   XM_004834672
- Peptide Label: isoform X2
- UniProtKB: G5ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110524   ⟸   XM_021254865
- Peptide Label: isoform X4
- UniProtKB: G5ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110523   ⟸   XM_021254864
- Peptide Label: isoform X4
- UniProtKB: G5ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000024059   ⟸   ENSHGLT00000024278
RefSeq Acc Id: ENSHGLP00000024058   ⟸   ENSHGLT00000024277


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017149 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024277 ENTREZGENE
  ENSHGLT00000024278 ENTREZGENE
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
InterPro RH_dom UniProtKB/TrEMBL
  RUBC_PIKBD UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
NCBI Gene Rubcn ENTREZGENE
PANTHER PHOX (PX) DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam RUBC_PIKBD UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  zf-RING_9 UniProtKB/TrEMBL
PROSITE RUN UniProtKB/TrEMBL
SMART DUF4206 UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
Superfamily-SCOP RUN domain-like UniProtKB/TrEMBL
UniProt G5ALA9 ENTREZGENE, UniProtKB/TrEMBL