Tnk1 (tyrosine kinase non receptor 1) - Rat Genome Database

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Gene: Tnk1 (tyrosine kinase non receptor 1) Heterocephalus glaber
Analyze
Symbol: Tnk1
Name: tyrosine kinase non receptor 1
RGD ID: 18921006
Description: ENCODES a protein that exhibits non-membrane spanning protein tyrosine kinase activity (ortholog); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of Ras protein signal transduction (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); congenital myasthenic syndrome 2A (ortholog); dyskeratosis congenita (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: non-receptor tyrosine-protein kinase TNK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,997,089 - 10,003,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,995,167 - 10,003,298 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
membrane  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,997,089 - 10,003,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,995,167 - 10,003,298 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TNK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,380,047 - 7,389,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,380,534 - 7,389,774 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,284,408 - 7,293,061 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,225,089 - 7,233,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,225,133 - 7,233,780NCBI
Celera177,310,277 - 7,319,007 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,178,337 - 7,187,140 (+)NCBIHuRef
CHM1_1177,293,383 - 7,302,185 (+)NCBICHM1_1
T2T-CHM13v2.0177,285,126 - 7,293,784 (+)NCBIT2T-CHM13v2.0
Tnk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,741,389 - 69,749,556 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,741,831 - 69,749,556 (-)EnsemblGRCm39 Ensembl
GRCm381169,850,563 - 69,858,730 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,851,005 - 69,858,730 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,664,065 - 69,672,232 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,435,206 - 70,442,824 (-)NCBIMGSCv36mm8
MGSCv361169,667,294 - 69,674,912 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.9NCBI
Tnk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,070,362 - 55,084,383 (-)NCBIGRCr8
mRatBN7.21054,571,396 - 54,580,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,571,117 - 54,579,940 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,234,510 - 59,240,807 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,723,078 - 58,729,377 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,230,740 - 54,237,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,458,650 - 56,475,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,459,108 - 56,465,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,203,769 - 56,212,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,692,319 - 56,698,602 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,705,941 - 56,714,918 (-)NCBI
Celera1053,726,241 - 53,732,527 (-)NCBICelera
Cytogenetic Map10q24NCBI
Tnk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,539,693 - 9,547,279 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,539,693 - 9,547,419 (-)NCBIChiLan1.0ChiLan1.0
TNK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,977,433 - 14,986,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,942,935 - 16,952,381 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,403,403 - 7,423,942 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,390,752 - 7,410,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,403,209 - 7,409,366 (+)Ensemblpanpan1.1panPan2
TNK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,320,029 - 32,326,829 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,321,272 - 32,326,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,457,980 - 32,464,791 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,425,348 - 32,432,175 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,425,395 - 32,432,143 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,390,791 - 32,397,611 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,349,550 - 32,356,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,526,593 - 32,533,420 (+)NCBIUU_Cfam_GSD_1.0
Tnk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,194,112 - 47,200,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595668,315 - 674,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595667,956 - 674,681 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,711,921 - 52,719,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,711,133 - 52,719,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,930,712 - 54,937,825 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,754,825 - 6,765,336 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,758,127 - 6,766,886 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,643,220 - 14,650,456 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000020474   ⟹   ENSHGLP00000020272
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247869,997,089 - 10,003,553 (+)Ensembl
RefSeq Acc Id: XM_004857411   ⟹   XP_004857468
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247869,995,169 - 10,003,298 (+)NCBI
RefSeq Acc Id: XM_021238300   ⟹   XP_021093959
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247869,995,495 - 10,003,298 (+)NCBI
RefSeq Acc Id: XM_021238301   ⟹   XP_021093960
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247869,995,167 - 10,003,298 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004857468 (Get FASTA)   NCBI Sequence Viewer  
  XP_021093959 (Get FASTA)   NCBI Sequence Viewer  
  XP_021093960 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000020272
Reference Protein Sequences
RefSeq Acc Id: XP_021093960   ⟸   XM_021238301
- Peptide Label: isoform X2
- UniProtKB: G5B5B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004857468   ⟸   XM_004857411
- Peptide Label: isoform X1
- UniProtKB: G5B5B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093959   ⟸   XM_021238300
- Peptide Label: isoform X1
- UniProtKB: G5B5B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000020272   ⟸   ENSHGLT00000020474


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014504 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020474 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  TNK-like_SAM UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Tnk1 ENTREZGENE
PANTHER NON-RECEPTOR TYROSINE-PROTEIN KINASE TNK1 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
  SH3-domain UniProtKB/TrEMBL
UniProt G5B5B5 ENTREZGENE, UniProtKB/TrEMBL