Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) - Rat Genome Database

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Gene: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) Heterocephalus glaber
Analyze
Symbol: Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
RGD ID: 18920672
Description: ENCODES a protein that exhibits tRNA binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); cellular response to cold (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH amino acid metabolic disorder (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eIF-2-alpha kinase GCN2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,262,163 - 7,376,267 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Eif2ak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,262,163 - 7,376,267 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EIF2AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,934,115 - 40,035,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1539,934,115 - 40,035,591 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,226,316 - 40,327,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,013,639 - 38,115,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,033,406 - 38,115,083NCBI
Celera1516,989,625 - 17,091,096 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,070,557 - 17,171,948 (+)NCBIHuRef
CHM1_11540,345,975 - 40,447,471 (+)NCBICHM1_1
T2T-CHM13v2.01537,739,435 - 37,840,931 (+)NCBIT2T-CHM13v2.0
Eif2ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,219,065 - 118,305,715 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,219,099 - 118,305,715 (+)EnsemblGRCm39 Ensembl
GRCm382118,388,583 - 118,475,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,214,353 - 118,300,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,080,058 - 118,166,674 (+)NCBIMGSCv36mm8
Celera2119,539,566 - 119,626,375 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Eif2ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,810,207 - 125,895,574 (+)NCBIGRCr8
mRatBN7.23105,356,261 - 105,441,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,356,261 - 105,441,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,022,930 - 109,108,350 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,618,459 - 117,703,890 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,278,837 - 115,364,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,159,624 - 110,245,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,159,708 - 110,249,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,705,333 - 116,791,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,870,871 - 104,875,529 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,716,669 - 104,802,714 (+)NCBI
Celera3104,273,489 - 104,358,836 (+)NCBICelera
Cytogenetic Map3q35NCBI
Eif2ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,897,848 - 7,009,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,897,897 - 7,005,602 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,171,788 - 29,273,327 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,323,160 - 33,424,672 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01518,871,867 - 18,973,380 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,128,000 - 37,229,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,120,044 - 37,229,211 (+)Ensemblpanpan1.1panPan2
EIF2AK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,144,727 - 7,248,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,144,570 - 7,248,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,199,521 - 7,302,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,271,731 - 7,376,532 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1307,195,772 - 7,298,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,301,246 - 7,405,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,430,444 - 7,533,631 (+)NCBIUU_Cfam_GSD_1.0
Eif2ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,575,724 - 85,679,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,423,813 - 3,526,913 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,423,792 - 3,527,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,245,466 - 131,355,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,244,818 - 131,355,240 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,476,415 - 146,493,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,966,095 - 43,072,083 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,962,447 - 43,072,001 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,883,347 - 97,988,989 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000008806   ⟹   ENSHGLP00000008711
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248047,262,163 - 7,376,267 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000008807   ⟹   ENSHGLP00000008712
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248047,262,163 - 7,376,267 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000008808   ⟹   ENSHGLP00000008713
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248047,274,603 - 7,371,338 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000008809   ⟹   ENSHGLP00000008714
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248047,276,537 - 7,371,338 (+)Ensembl
RefSeq Acc Id: XM_004861532   ⟹   XP_004861589
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBI
RefSeq Acc Id: XM_004861533   ⟹   XP_004861590
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248047,262,318 - 7,371,506 (+)NCBI
RefSeq Acc Id: XM_013078442   ⟹   XP_012933896
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248047,262,330 - 7,371,506 (+)NCBI
RefSeq Acc Id: XM_013078443   ⟹   XP_012933897
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBI
RefSeq Acc Id: XM_021241941   ⟹   XP_021097600
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248047,290,743 - 7,371,506 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004861589   ⟸   XM_004861532
- Peptide Label: isoform X1
- UniProtKB: G5BLY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933897   ⟸   XM_013078443
- Peptide Label: isoform X3
- UniProtKB: G5BLY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004861590   ⟸   XM_004861533
- Peptide Label: isoform X4
- UniProtKB: G5BLY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933896   ⟸   XM_013078442
- Peptide Label: isoform X2
- UniProtKB: G5BLY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021097600   ⟸   XM_021241941
- Peptide Label: isoform X5
RefSeq Acc Id: ENSHGLP00000008714   ⟸   ENSHGLT00000008809
RefSeq Acc Id: ENSHGLP00000008712   ⟸   ENSHGLT00000008807
RefSeq Acc Id: ENSHGLP00000008713   ⟸   ENSHGLT00000008808
RefSeq Acc Id: ENSHGLP00000008711   ⟸   ENSHGLT00000008806


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006278 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008806 ENTREZGENE
  ENSHGLT00000008807 ENTREZGENE
  ENSHGLT00000008809 ENTREZGENE
Gene3D-CATH Anticodon-binding domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Ubiquitin Conjugating Enzyme UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/TrEMBL
  HisRS-like_core UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RWD-domain UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
NCBI Gene Eif2ak4 ENTREZGENE
PANTHER EIF-2-ALPHA KINASE GCN2 UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  RWD UniProtKB/TrEMBL
  tRNA-synt_His UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RWD UniProtKB/TrEMBL
SMART RWD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Class II aaRS and biotin synthetases UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  UBC-like UniProtKB/TrEMBL
UniProt G5BLY0 ENTREZGENE, UniProtKB/TrEMBL