Spi1 (Spi-1 proto-oncogene) - Rat Genome Database

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Pathways
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Gene: Spi1 (Spi-1 proto-oncogene) Heterocephalus glaber
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene
RGD ID: 18918503
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anatomical structure regression (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); cellular response to ethanol (ortholog); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); agammaglobulinemia 10 (ortholog); alcohol use disorder (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
cell differentiation  (IEA)
cellular response to ethanol  (ISO)
defense response to tumor cell  (ISO)
endothelial to hematopoietic transition  (ISO)
erythrocyte differentiation  (ISO)
follicular B cell differentiation  (ISO)
germinal center B cell differentiation  (ISO)
granulocyte differentiation  (ISO)
immature B cell differentiation  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lymphocyte differentiation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage differentiation  (ISO)
myeloid dendritic cell differentiation  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of neutrophil degranulation  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
oncogene-induced cell senescence  (ISO)
osteoclast differentiation  (ISO)
pericyte cell differentiation  (ISO)
positive regulation of antifungal innate immune response  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of microglial cell mediated cytotoxicity  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of myeloid dendritic cell chemotaxis  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pro-T cell differentiation  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of myeloid progenitor cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to ethanol  (ISO)
somatic stem cell population maintenance  (ISO)
TRAIL-activated apoptotic signaling pathway  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,354,860 - 47,378,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,354,860 - 47,409,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
T2T-CHM13v2.01147,511,687 - 47,538,667 (-)NCBIT2T-CHM13v2.0
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)EnsemblGRCm39 Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBIMGSCv36mm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,555,991 - 49,581,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,575,785 - 49,601,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,908,267 - 42,924,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBIUU_Cfam_GSD_1.0
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,852,740 - 1,870,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,881 - 15,245,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016190   ⟹   ENSHGLP00000016021
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)Ensembl
RefSeq Acc Id: XM_004851854   ⟹   XP_004851911
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247671,394,717 - 1,404,378 (+)NCBI
RefSeq Acc Id: XM_004851856   ⟹   XP_004851913
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247671,394,722 - 1,404,374 (+)NCBI
RefSeq Acc Id: XM_021264205   ⟹   XP_021119864
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBI
RefSeq Acc Id: XM_021264206   ⟹   XP_021119865
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBI
RefSeq Acc Id: XM_021264207   ⟹   XP_021119866
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247671,376,649 - 1,404,379 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004851911 (Get FASTA)   NCBI Sequence Viewer  
  XP_004851913 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119864 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119865 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119866 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016021
GenBank Protein JAN95994 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021119864   ⟸   XM_021264205
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021119865   ⟸   XM_021264206
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021119866   ⟸   XM_021264207
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004851911   ⟸   XM_004851854
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004851913   ⟸   XM_004851856
- Peptide Label: isoform X5
- UniProtKB: A0A0P6J1L0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016021   ⟸   ENSHGLT00000016190


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011456 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016190 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/TrEMBL
  ETS_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Spi1 ENTREZGENE
PANTHER PTHR11849 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR PU.1 UniProtKB/TrEMBL
Pfam Ets UniProtKB/TrEMBL
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
SMART ETS UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0P6J1L0 ENTREZGENE, UniProtKB/TrEMBL