Adra2a (adrenoceptor alpha 2A) - Rat Genome Database

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Gene: Adra2a (adrenoceptor alpha 2A) Heterocephalus glaber
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Symbol: Adra2a
Name: adrenoceptor alpha 2A
RGD ID: 18918194
Description: ENCODES a protein that exhibits adrenergic receptor activity (ortholog); alpha-1B adrenergic receptor binding (ortholog); alpha-2C adrenergic receptor binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); activation of protein kinase B activity (ortholog); adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); alcohol dependence (ortholog); anxiety disorder (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-2A adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adrenergic receptor signaling pathway  (IEA)
cellular response to hormone stimulus  (ISO)
DNA replication  (ISO)
fear response  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of uterine smooth muscle contraction  (ISO)
phospholipase C-activating adrenergic receptor signaling pathway  (ISO)
platelet activation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of wound healing  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of smooth muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to alcohol  (ISO)
response to morphine  (ISO)
thermoception  (ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adra2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ADRA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10111,077,029 - 111,080,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,836,787 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBICelera
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
T2T-CHM13v2.010111,960,874 - 111,964,752 (+)NCBIT2T-CHM13v2.0
Adra2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391954,033,690 - 54,037,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1954,032,582 - 54,037,413 (+)EnsemblGRCm39 Ensembl
GRCm381954,045,259 - 54,048,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1954,044,151 - 54,048,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv371954,119,672 - 54,123,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361954,098,545 - 54,102,294 (+)NCBIMGSCv36mm8
Celera1956,240,003 - 56,243,840 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1949.04NCBI
Adra2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81263,066,780 - 263,069,580 (+)NCBIGRCr8
mRatBN7.21253,061,480 - 253,064,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1261,250,961 - 261,253,761 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,957,040 - 267,959,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,612,912 - 260,615,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adra2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485385,800 - 387,240 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485384,405 - 387,332 (-)NCBIChiLan1.0ChiLan1.0
ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,957,240 - 122,972,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,963,626 - 122,966,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,669,860 - 107,673,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110111,119,153 - 111,122,369 (+)NCBIpanpan1.1PanPan1.1panPan2
ADRA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBIUU_Cfam_GSD_1.0
Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,720,233 - 23,724,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,838,176 - 1,839,630 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,837,785 - 1,841,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19104,015,577 - 104,019,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9104,016,580 - 104,017,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604865,215,363 - 65,219,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004838943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01015317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000028978   ⟹   ENSHGLP00000028490
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)Ensembl
RefSeq Acc Id: XM_004838943   ⟹   XP_004839000
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004839000 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000028490
RefSeq Acc Id: XP_004839000   ⟸   XM_004838943
- UniProtKB: A0AAX6NX89 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000028490   ⟸   ENSHGLT00000028978


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000020768 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000028978 ENTREZGENE
NCBI Gene Adra2a ENTREZGENE
UniProt A0AAX6NX89 ENTREZGENE, UniProtKB/TrEMBL