Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) Heterocephalus glaber
Analyze
Symbol: Huwe1
Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
RGD ID: 18918055
Description: ENCODES a protein that exhibits DNA binding (ortholog); histone ubiquitin ligase activity (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); negative regulation of mitochondrial fusion (ortholog); positive regulation of mitophagy in response to mitochondrial depolarization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH Atkin Syndrome (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909745,651 - 859,233 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
Golgi membrane  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Huwe1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909745,651 - 859,233 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HUWE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,532,096 - 53,686,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,532,096 - 53,686,752 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,559,057 - 53,713,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,576,476 - 53,697,776 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,390,630 - 57,545,232 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,615,901 - 50,769,910 (-)NCBIHuRef
CHM1_1X53,550,037 - 53,704,971 (-)NCBICHM1_1
T2T-CHM13v2.0X52,818,443 - 52,973,077 (-)NCBIT2T-CHM13v2.0
Huwe1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,583,779 - 150,718,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,583,803 - 150,718,413 (+)EnsemblGRCm39 Ensembl
GRCm38X151,800,785 - 151,935,417 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,800,807 - 151,935,417 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,237,825 - 148,369,960 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,144,043 - 147,275,608 (+)NCBIMGSCv36mm8
CeleraX132,494,924 - 132,629,529 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Huwe1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,350,708 - 24,480,798 (+)NCBIGRCr8
mRatBN7.2X20,873,795 - 21,001,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,873,795 - 21,001,262 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X21,474,627 - 21,603,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,499,934 - 21,598,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,848,515 - 21,950,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X23,634,031 - 23,635,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,269,837 - 41,397,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,152,936 - 21,282,567 (+)NCBICelera
Cytogenetic MapXq13NCBI
Huwe1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475551,159 - 671,747 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475550,643 - 671,771 (-)NCBIChiLan1.0ChiLan1.0
HUWE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,931,498 - 55,081,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,935,098 - 55,085,490 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,746,228 - 45,897,250 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,855,404 - 54,005,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,855,404 - 54,005,366 (-)Ensemblpanpan1.1panPan2
HUWE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,234,666 - 45,409,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,234,322 - 45,410,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,751,409 - 36,836,872 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,559,669 - 45,734,540 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,559,746 - 45,731,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X45,054,717 - 45,229,543 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,504,350 - 45,679,158 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,571,951 - 45,747,074 (-)NCBIUU_Cfam_GSD_1.0
Huwe1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X38,139,253 - 38,283,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751478,300 - 622,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751478,978 - 622,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HUWE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,281,967 - 46,444,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,281,958 - 46,444,315 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,780,471 - 51,942,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HUWE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,661,506 - 49,814,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,660,790 - 49,808,572 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,622,912 - 3,777,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013068752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013068762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021251227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021251228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021251229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021251230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01102791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01102792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01102793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01006008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH174082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000003404   ⟹   ENSHGLP00000003349
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624909745,651 - 859,233 (-)Ensembl
RefSeq Acc Id: XM_013068752   ⟹   XP_012924206
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068753   ⟹   XP_012924207
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 888,884 (-)NCBI
RefSeq Acc Id: XM_013068754   ⟹   XP_012924208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 888,933 (-)NCBI
RefSeq Acc Id: XM_013068756   ⟹   XP_012924210
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068757   ⟹   XP_012924211
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 888,720 (-)NCBI
RefSeq Acc Id: XM_013068758   ⟹   XP_012924212
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068759   ⟹   XP_012924213
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068760   ⟹   XP_012924214
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068761   ⟹   XP_012924215
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_013068762   ⟹   XP_012924216
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_021251227   ⟹   XP_021106886
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 888,337 (-)NCBI
RefSeq Acc Id: XM_021251228   ⟹   XP_021106887
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 888,529 (-)NCBI
RefSeq Acc Id: XM_021251229   ⟹   XP_021106888
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
RefSeq Acc Id: XM_021251230   ⟹   XP_021106889
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624909745,141 - 891,421 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012924210   ⟸   XM_013068756
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924213   ⟸   XM_013068759
- Peptide Label: isoform X4
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106888   ⟸   XM_021251229
- Peptide Label: isoform X3
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924216   ⟸   XM_013068762
- Peptide Label: isoform X8
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924215   ⟸   XM_013068761
- Peptide Label: isoform X7
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106889   ⟸   XM_021251230
- Peptide Label: isoform X6
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924214   ⟸   XM_013068760
- Peptide Label: isoform X5
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924212   ⟸   XM_013068758
- Peptide Label: isoform X2
- UniProtKB: A0A0P6K1Y5 (UniProtKB/TrEMBL),   G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924206   ⟸   XM_013068752
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924208   ⟸   XM_013068754
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924207   ⟸   XM_013068753
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924211   ⟸   XM_013068757
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106887   ⟸   XM_021251228
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106886   ⟸   XM_021251227
- Peptide Label: isoform X1
- UniProtKB: G5C9Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000003349   ⟸   ENSHGLT00000003404


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002470 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003404 ENTREZGENE
Gene3D-CATH 3.30.720.50 UniProtKB/TrEMBL
  6.10.250.1630 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  E3_Ub_ligase_DUF908 UniProtKB/TrEMBL
  E3_Ub_ligase_DUF913 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HUWE1/Rev1_UBM UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
  UBA_HUWE1 UniProtKB/TrEMBL
  WWE-dom UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/TrEMBL
NCBI Gene Huwe1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HUWE1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam DUF908 UniProtKB/TrEMBL
  DUF913 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  UBM UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP SSF117839 UniProtKB/TrEMBL
  SSF46934 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A0P6K1Y5 ENTREZGENE, UniProtKB/TrEMBL
  G5C9Y4 ENTREZGENE, UniProtKB/TrEMBL