Plekhm1 (pleckstrin homology and RUN domain containing M1) - Rat Genome Database

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Gene: Plekhm1 (pleckstrin homology and RUN domain containing M1) Heterocephalus glaber
Analyze
Symbol: Plekhm1
Name: pleckstrin homology and RUN domain containing M1
RGD ID: 18917128
Description: ENCODES a protein that exhibits metal ion binding (inferred); INVOLVED IN autophagosome-lysosome fusion (ortholog); late endosome to lysosome transport (ortholog); lysosome localization (ortholog); ASSOCIATED WITH Autosomal Dominant Osteopetrosis 3 (ortholog); autosomal recessive osteopetrosis 1 (ortholog); autosomal recessive osteopetrosis 6 (ortholog); FOUND IN autolysosome (ortholog); intracellular membrane-bounded organelle (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family M member 1; Pleckstrin-like protein domain-containing family M member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479537,059 - 89,135 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479537,059 - 86,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625  


Genomics

Comparative Map Data
Plekhm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479537,059 - 89,135 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479537,059 - 86,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PLEKHM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,434,209 - 45,490,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,435,900 - 45,490,758 (-)EnsemblGRCh38hg38GRCh38
GRCh371743,513,266 - 43,568,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,869,049 - 40,923,893 (-)NCBINCBI36Build 36hg18NCBI36
Build 341740,869,049 - 40,923,893NCBI
Celera1740,222,636 - 40,240,265 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,273,955 - 39,296,473 (-)NCBIHuRef
CHM1_11743,748,483 - 43,803,013 (-)NCBICHM1_1
T2T-CHM13v2.01746,286,496 - 46,344,437 (-)NCBIT2T-CHM13v2.0
Plekhm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,255,101 - 103,303,531 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,255,101 - 103,303,513 (-)EnsemblGRCm39 Ensembl
GRCm3811103,364,275 - 103,412,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,364,275 - 103,412,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711103,226,406 - 103,273,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,181,182 - 103,228,754 (-)NCBIMGSCv36mm8
Celera11115,076,577 - 115,124,001 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.09NCBI
Plekhm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,814,699 - 88,876,570 (-)NCBIGRCr8
mRatBN7.21088,313,837 - 88,366,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,314,651 - 88,362,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,350,638 - 93,398,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,817,686 - 92,865,455 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,211,041 - 88,258,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,451,890 - 91,500,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,451,865 - 91,500,661 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,218,325 - 91,267,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,555,565 - 92,603,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,569,935 - 92,617,694 (-)NCBI
Celera1087,015,274 - 87,063,066 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Plekhm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545118,043,194 - 18,079,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545118,043,194 - 18,079,808 (-)NCBIChiLan1.0ChiLan1.0
PLEKHM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,346,261 - 19,401,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,314,716 - 21,370,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01711,836,726 - 11,891,614 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,011,518 - 12,063,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,011,604 - 12,063,912 (+)Ensemblpanpan1.1panPan2
PLEKHM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha911,333,769 - 11,374,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0918,791,160 - 18,837,560 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1910,919,802 - 10,960,705 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0918,009,047 - 18,050,225 (+)NCBIUU_Cfam_GSD_1.0
Plekhm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,462,211 - 17,508,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,685,923 - 1,732,420 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,685,902 - 1,732,361 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,993,036 - 18,035,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,984,169 - 18,035,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,150,933 - 18,202,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,926,006 - 60,980,359 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1660,926,063 - 60,980,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607731,663,243 - 31,719,233 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016810   ⟹   ENSHGLP00000016640
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479537,059 - 89,135 (+)Ensembl
RefSeq Acc Id: XM_004859170   ⟹   XP_004859227
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479537,059 - 86,568 (+)NCBI
RefSeq Acc Id: XM_004859171   ⟹   XP_004859228
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479537,059 - 84,674 (+)NCBI
RefSeq Acc Id: XM_021240057   ⟹   XP_021095716
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479545,748 - 86,568 (+)NCBI
RefSeq Acc Id: XM_021240058   ⟹   XP_021095717
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479537,059 - 80,843 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004859227 (Get FASTA)   NCBI Sequence Viewer  
  XP_004859228 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095716 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095717 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016640
GenBank Protein JAN98411 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004859227   ⟸   XM_004859170
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4I2 (UniProtKB/TrEMBL),   G5BIZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859228   ⟸   XM_004859171
- Peptide Label: isoform X2
- UniProtKB: G5BIZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095717   ⟸   XM_021240058
- Peptide Label: isoform X4
- UniProtKB: G5BIZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095716   ⟸   XM_021240057
- Peptide Label: isoform X3
- UniProtKB: G5BIZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016640   ⟸   ENSHGLT00000016810


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011903 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016810 ENTREZGENE
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_PLEKHM1 UniProtKB/TrEMBL
  Zf-RING_9 UniProtKB/TrEMBL
KEGG Report hgl:101701904 UniProtKB/TrEMBL
NCBI Gene Plekhm1 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1 UniProtKB/TrEMBL
Pfam RUN UniProtKB/TrEMBL
  zf-RING_9 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART DUF4206 UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF140741 UniProtKB/TrEMBL
UniProt A0A0P6J4I2 ENTREZGENE, UniProtKB/TrEMBL
  G5BIZ3 ENTREZGENE, UniProtKB/TrEMBL