Wdr54 (WD repeat domain 54) - Rat Genome Database

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Gene: Wdr54 (WD repeat domain 54) Heterocephalus glaber
Analyze
Symbol: Wdr54
Name: WD repeat domain 54
RGD ID: 18916621
Description: ENCODES a protein that exhibits protein homodimerization activity (inferred); INVOLVED IN negative regulation of receptor internalization (inferred); regulation of epidermal growth factor receptor signaling pathway (inferred); regulation of MAPK cascade (inferred); ASSOCIATED WITH congenital disorder of glycosylation type IIb (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); vesicle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat-containing protein 54
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,076,554 - 29,080,128 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wdr54
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,076,554 - 29,080,128 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
WDR54
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,421,730 - 74,425,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,421,678 - 74,425,755 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,648,857 - 74,652,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,502,393 - 74,506,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,560,539 - 74,564,536NCBI
Celera274,480,074 - 74,484,071 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,385,197 - 74,389,194 (+)NCBIHuRef
CHM1_1274,578,303 - 74,582,300 (+)NCBICHM1_1
T2T-CHM13v2.0274,430,287 - 74,434,312 (+)NCBIT2T-CHM13v2.0
Wdr54
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,129,691 - 83,133,383 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,126,342 - 83,133,379 (-)EnsemblGRCm39 Ensembl
GRCm38683,152,710 - 83,156,524 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,149,361 - 83,156,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,102,704 - 83,106,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,118,406 - 83,122,025 (-)NCBIMGSCv36mm8
Celera685,135,616 - 85,139,287 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Wdr54
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,212,677 - 117,236,456 (-)NCBIGRCr8
mRatBN7.24115,654,968 - 115,677,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,654,968 - 115,661,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,131,661 - 121,138,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,906,844 - 116,913,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,521,131 - 115,527,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,847,722 - 114,871,989 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,981,653 - 113,988,246 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,850,815 - 114,853,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,436,792 - 179,460,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,360,988 - 117,367,581 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,649,110 - 104,655,703 (-)NCBICelera
Cytogenetic Map4q34NCBI
Wdr54
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,358,694 - 11,362,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,358,694 - 11,362,138 (-)NCBIChiLan1.0ChiLan1.0
WDR54
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,963,500 - 51,967,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,966,253 - 51,970,289 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,488,345 - 74,492,392 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,994,378 - 75,998,385 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,994,394 - 75,998,385 (+)Ensemblpanpan1.1panPan2
WDR54
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,700,432 - 48,734,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,700,431 - 48,704,344 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,342,069 - 48,375,651 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,559,726 - 49,593,603 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,559,725 - 49,563,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,576,773 - 48,610,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,643,308 - 48,676,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,201,309 - 49,235,141 (-)NCBIUU_Cfam_GSD_1.0
Wdr54
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,087,698 - 10,091,606 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556645,933 - 662,452 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556646,312 - 649,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR54
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,614,020 - 68,622,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,614,019 - 68,618,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,804,660 - 71,809,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR54
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,851,904 - 32,855,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,851,959 - 32,855,912 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,314,481 - 79,318,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000013483   ⟹   ENSHGLP00000013343
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474929,076,554 - 29,080,128 (-)Ensembl
RefSeq Acc Id: XM_004844681   ⟹   XP_004844738
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBI
RefSeq Acc Id: XM_004844682   ⟹   XP_004844739
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBI
RefSeq Acc Id: XM_013072214   ⟹   XP_012927668
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBI
RefSeq Acc Id: XM_021258279   ⟹   XP_021113938
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474929,076,668 - 29,080,169 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004844738 (Get FASTA)   NCBI Sequence Viewer  
  XP_004844739 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927668 (Get FASTA)   NCBI Sequence Viewer  
  XP_021113938 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000013343
  ENSHGLP00000043212
  ENSHGLP00100047618
GenBank Protein JAO01988 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004844738   ⟸   XM_004844681
- Peptide Label: isoform X4
- UniProtKB: G5AXF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927668   ⟸   XM_013072214
- Peptide Label: isoform X3
- UniProtKB: G5AXF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113938   ⟸   XM_021258279
- Peptide Label: isoform X2
- UniProtKB: G5AXF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004844739   ⟸   XM_004844682
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JDF4 (UniProtKB/TrEMBL),   G5AXF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000013343   ⟸   ENSHGLT00000013483


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009538 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100012439 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000013483 ENTREZGENE
  ENSHGLT00000059623 UniProtKB/TrEMBL
  ENSHGLT00100075765 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDR54_beta_propeller UniProtKB/TrEMBL
NCBI Gene Wdr54 ENTREZGENE
PANTHER WD REPEAT-CONTAINING PROTEIN 54 UniProtKB/TrEMBL
  WD-40 REPEAT PROTEIN UniProtKB/TrEMBL
Pfam WDR54 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A0P6JDF4 ENTREZGENE, UniProtKB/TrEMBL
  G5AXF9 ENTREZGENE, UniProtKB/TrEMBL