Thbd (thrombomodulin) - Rat Genome Database

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Gene: Thbd (thrombomodulin) Heterocephalus glaber
Analyze
Symbol: Thbd
Name: thrombomodulin
RGD ID: 18914348
Description: ENCODES a protein that exhibits signaling receptor activity (ortholog); INVOLVED IN female pregnancy (ortholog); negative regulation of blood coagulation (ortholog); response to cAMP (ortholog); PARTICIPATES IN protein C anticoagulant pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN apicolateral plasma membrane (ortholog); cell surface (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474122,880,481 - 22,883,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
asthma  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Injuries  (ISO)
brain small vessel disease  (ISO)
carotid artery thrombosis  (ISO)
cerebral infarction  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dermatomyositis  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial combined hyperlipidemia  (ISO)
familial hyperinsulinemic hypoglycemia 1  (ISO)
familial Mediterranean fever  (ISO)
genetic disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Habitual Abortions  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (ISO)
hemorrhagic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
idiopathic pulmonary fibrosis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
liver disease  (ISO)
lung non-small cell carcinoma  (ISO)
Metabolic Syndrome  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
Painful Neuropathy  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombomodulin defect  (ISO)
thrombosis  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Thbd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474122,880,481 - 22,883,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
THBD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,045,633 - 23,049,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,045,633 - 23,049,672 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,026,270 - 23,030,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,974,270 - 22,978,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 342022,974,270 - 22,978,301NCBI
Celera2023,099,650 - 23,103,681 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2022,987,792 - 22,991,823 (-)NCBIHuRef
CHM1_12023,026,970 - 23,031,001 (-)NCBICHM1_1
T2T-CHM13v2.02023,105,114 - 23,109,153 (-)NCBIT2T-CHM13v2.0
Thbd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,246,391 - 148,250,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)EnsemblGRCm39 Ensembl
GRCm382148,404,471 - 148,408,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,230,207 - 148,233,924 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,095,912 - 148,099,544 (-)NCBIMGSCv36mm8
Celera2149,679,568 - 149,683,285 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.45NCBI
Thbd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,316,526 - 156,320,178 (-)NCBIGRCr8
mRatBN7.23135,863,366 - 135,867,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,862,835 - 135,867,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3139,806,359 - 139,810,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,390,492 - 148,394,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,088,993 - 146,092,645 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03142,748,673 - 142,752,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,748,674 - 142,752,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,159,895 - 149,163,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,158,955 - 137,162,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,064,528 - 137,068,180 (-)NCBI
Celera3134,707,185 - 134,710,838 (-)NCBICelera
Cytogenetic Map3q41NCBI
Thbd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541530,222,830 - 30,226,406 (-)NCBIChiLan1.0ChiLan1.0
THBD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22123,923,797 - 23,935,661 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12023,920,631 - 23,932,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02022,992,341 - 22,996,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,343,758 - 23,347,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,345,917 - 23,347,812 (-)Ensemblpanpan1.1panPan2
THBD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.124599,773 - 601,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl24599,773 - 601,649 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24624,590 - 626,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024996,254 - 998,130 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24996,254 - 998,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124595,131 - 597,007 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024697,184 - 699,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024978,557 - 980,433 (+)NCBIUU_Cfam_GSD_1.0
Thbd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,143,805 - 149,147,659 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366202,563,900 - 2,568,117 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,217,303 - 30,224,099 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,219,870 - 30,223,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,274,132 - 34,277,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,041,950 - 52,045,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,043,746 - 52,045,626 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660786,853,490 - 6,857,509 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004840907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01019610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_004840907   ⟹   XP_004840964
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474122,880,481 - 22,883,962 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004840964 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004840964   ⟸   XM_004840907
- UniProtKB: G5CBC6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Gene3D-CATH Laminin UniProtKB/TrEMBL
  Mannose-Binding Protein A, subunit A UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Spindle_Org/Thrombomodulin UniProtKB/TrEMBL
  Tme5_EGF-like UniProtKB/TrEMBL
NCBI Gene Thbd ENTREZGENE
PANTHER SKELETOR-RELATED UniProtKB/TrEMBL
  THROMBOMODULIN UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
  Tme5_EGF_like UniProtKB/TrEMBL
PIRSF CD93/CD141 UniProtKB/TrEMBL
PRINTS THRMBOMODULN UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  Growth factor receptor domain UniProtKB/TrEMBL
UniProt G5CBC6 ENTREZGENE, UniProtKB/TrEMBL