Abcc9 (ATP binding cassette subfamily C member 9) - Rat Genome Database

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Pathways
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Gene: Abcc9 (ATP binding cassette subfamily C member 9) Heterocephalus glaber
Analyze
Symbol: Abcc9
Name: ATP binding cassette subfamily C member 9
RGD ID: 18913900
Description: ENCODES a protein that exhibits ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heterocyclic compound binding (ortholog); identical protein binding (ortholog); INVOLVED IN action potential (ortholog); ATP metabolic process (ortholog); blood circulation (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); breast ductal carcinoma (ortholog); Brugada syndrome (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); inward rectifying potassium channel (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family C member 9; ATP-binding cassette sub-family C member 9 isoform SUR2B; ATP-binding cassette transporter sub-family C member 9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,792,165 - 16,927,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,792,202 - 16,926,552 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
ATP metabolic process  (ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
cardiac conduction  (ISO)
cardiac muscle cell contraction  (ISO)
cellular respiration  (ISO)
cellular response to ATP  (ISO)
cellular response to calcium ion  (ISO)
cellular response to chemical stress  (ISO)
cellular response to potassium ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circulatory system development  (ISO)
coronary vasculature development  (ISO)
defense response to virus  (ISO)
fatty acid oxidation  (ISO)
fibroblast proliferation  (ISO)
gene expression  (ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
inorganic cation transmembrane transport  (ISO)
MAPK cascade  (ISO)
mitochondrion organization  (ISO)
monoatomic cation transmembrane transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
oxygen metabolic process  (ISO)
potassium ion import across plasma membrane  (ISO)
potassium ion transmembrane transport  (ISO)
potassium ion transport  (IEA,ISO)
reactive oxygen species biosynthetic process  (ISO)
regulation of blood pressure  (ISO)
regulation of cation channel activity  (ISO)
regulation of membrane potential  (ISO)
regulation of potassium ion transmembrane transport  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  (ISO)
response to activity  (ISO)
response to ATP  (ISO)
response to decreased oxygen levels  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hydrogen sulfide  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to peptide  (ISO)
response to potassium ion  (ISO)
response to stress  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (ISO)
transmembrane transport  (IEA)
vascular process in circulatory system  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Abcc9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,792,165 - 16,927,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,792,202 - 16,926,552 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ABCC9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,797,389 - 21,941,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,797,389 - 21,942,543 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,950,323 - 22,094,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,841,590 - 21,980,895 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,849,374 - 21,980,875NCBI
Celera1227,105,336 - 27,244,581 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,723,876 - 21,863,675 (-)NCBIHuRef
CHM1_11221,915,604 - 22,054,751 (-)NCBICHM1_1
T2T-CHM13v2.01221,676,073 - 21,820,886 (-)NCBIT2T-CHM13v2.0
Abcc9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,533,592 - 142,648,472 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,533,588 - 142,648,041 (-)EnsemblGRCm39 Ensembl
GRCm386142,587,862 - 142,702,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,587,862 - 142,702,315 (-)EnsemblGRCm38mm10GRCm38
MGSCv376142,536,382 - 142,650,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,546,355 - 142,659,495 (-)NCBIMGSCv36mm8
Celera6145,649,701 - 145,764,495 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.35NCBI
Abcc9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,262,848 - 177,386,837 (-)NCBIGRCr8
mRatBN7.24175,531,854 - 175,655,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,532,547 - 175,655,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,826,663 - 181,950,019 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,610,938 - 177,734,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,231,509 - 176,354,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,806,098 - 176,928,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,805,431 - 176,922,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04241,019,980 - 241,139,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,165,979 - 180,236,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,877,146 - 33,883,992NCBI
Celera4164,064,977 - 164,186,502 (-)NCBICelera
Cytogenetic Map4q44NCBI
Abcc9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,382,564 - 17,510,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,385,966 - 17,510,220 (-)NCBIChiLan1.0ChiLan1.0
ABCC9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21074,851,373 - 75,004,445 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11274,856,027 - 75,000,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,357,176 - 64,500,358 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11266,960,888 - 67,102,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1266,960,888 - 67,102,496 (+)Ensemblpanpan1.1panPan2
ABCC9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,199,580 - 25,352,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,200,418 - 25,388,477 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2721,008,307 - 21,161,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,419,340 - 25,572,249 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,419,332 - 25,572,207 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,218,211 - 25,370,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,241,668 - 25,394,276 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,179,155 - 21,329,671 (-)NCBIUU_Cfam_GSD_1.0
Abcc9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,079,120 - 87,187,785 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365484,987,847 - 5,108,104 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365484,983,461 - 5,110,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,536,526 - 51,691,595 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,536,531 - 51,673,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,818,859 - 54,944,118 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,658,804 - 21,797,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,658,794 - 21,797,263 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,343,449 - 13,484,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000021133   ⟹   ENSHGLP00000020930
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475216,792,165 - 16,927,293 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000021134   ⟹   ENSHGLP00000020931
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475216,792,165 - 16,927,293 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000021135   ⟹   ENSHGLP00000020932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475216,796,813 - 16,919,922 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000021136   ⟹   ENSHGLP00000020933
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475216,796,813 - 16,919,922 (+)Ensembl
RefSeq Acc Id: XM_013072576   ⟹   XP_012928030
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,792,330 - 16,924,040 (+)NCBI
RefSeq Acc Id: XM_021259109   ⟹   XP_021114768
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,792,331 - 16,926,552 (+)NCBI
RefSeq Acc Id: XM_021259110   ⟹   XP_021114769
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,792,202 - 16,924,040 (+)NCBI
RefSeq Acc Id: XM_021259111   ⟹   XP_021114770
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,793,093 - 16,924,040 (+)NCBI
RefSeq Acc Id: XM_021259112   ⟹   XP_021114771
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,792,330 - 16,924,040 (+)NCBI
RefSeq Acc Id: XM_021259113   ⟹   XP_021114772
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,793,093 - 16,924,040 (+)NCBI
RefSeq Acc Id: XM_021259114   ⟹   XP_021114773
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475216,792,330 - 16,926,552 (+)NCBI
RefSeq Acc Id: XP_021114769   ⟸   XM_021259110
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114773   ⟸   XM_021259114
- Peptide Label: isoform X2
- UniProtKB: G5BEG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928030   ⟸   XM_013072576
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114771   ⟸   XM_021259112
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114768   ⟸   XM_021259109
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114772   ⟸   XM_021259113
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114770   ⟸   XM_021259111
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J5R4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020933   ⟸   ENSHGLT00000021136
Ensembl Acc Id: ENSHGLP00000020932   ⟸   ENSHGLT00000021135
Ensembl Acc Id: ENSHGLP00000020931   ⟸   ENSHGLT00000021134
Ensembl Acc Id: ENSHGLP00000020930   ⟸   ENSHGLT00000021133


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014958 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021133 ENTREZGENE
  ENSHGLT00000021134 ENTREZGENE
  ENSHGLT00000021135 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCC9 UniProtKB/TrEMBL
  ABCC9_ATP-bd_dom1 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Sulphorea_rcpt UniProtKB/TrEMBL
KEGG Report hgl:101698079 UniProtKB/TrEMBL
NCBI Gene Abcc9 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  PTHR24223:SF173 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PRINTS SULFNYLUR2 UniProtKB/TrEMBL
  SULFNYLUREAR UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A0P6J5R4 ENTREZGENE, UniProtKB/TrEMBL
  G5BEG4 ENTREZGENE, UniProtKB/TrEMBL