Slc6a2 (solute carrier family 6 member 2) - Rat Genome Database

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Pathways
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Gene: Slc6a2 (solute carrier family 6 member 2) Heterocephalus glaber
Analyze
Symbol: Slc6a2
Name: solute carrier family 6 member 2
RGD ID: 18913859
Description: ENCODES a protein that exhibits actin binding (ortholog); alpha-tubulin binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN monoamine transport (ortholog); neurotransmitter reuptake (ortholog); neurotransmitter transport (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); depressive disorder (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,294,064 - 1,332,856 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,292,811 - 1,332,868 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
desipramine pharmacokinetics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
imipramine pharmacokinetics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
venlafaxine pharmacokinetics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc6a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,294,064 - 1,332,856 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,292,811 - 1,332,868 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SLC6A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,655,988 - 55,706,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,655,988 - 55,707,645 (+)EnsemblGRCh38hg38GRCh38
GRCh371655,689,900 - 55,740,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,248,057 - 54,295,201 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,248,058 - 54,293,992NCBI
Celera1640,203,750 - 40,254,437 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,576,866 - 41,627,544 (+)NCBIHuRef
CHM1_11657,096,804 - 57,147,472 (+)NCBICHM1_1
T2T-CHM13v2.01661,454,123 - 61,504,416 (+)NCBIT2T-CHM13v2.0
Slc6a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,687,100 - 93,728,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,686,707 - 93,728,295 (+)EnsemblGRCm39 Ensembl
GRCm38892,960,470 - 93,001,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,960,079 - 93,001,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,484,946 - 95,525,566 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,850,358 - 95,890,795 (+)NCBIMGSCv36mm8
Celera897,290,444 - 97,331,118 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
Slc6a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,183,289 - 30,228,292 (-)NCBIGRCr8
mRatBN7.21914,010,292 - 14,055,317 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,010,386 - 14,050,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,705,759 - 15,746,177 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,900,533 - 20,940,947 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,846,114 - 23,886,538 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,391,682 - 15,431,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,391,581 - 15,431,274 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,487,820 - 26,527,769 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,098,281 - 15,139,898 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11915,103,106 - 15,144,724 (-)NCBI
Celera1913,934,272 - 13,973,888 (-)NCBICelera
Cytogenetic Map19p11NCBI
Slc6a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,170,699 - 13,216,330 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,170,986 - 13,216,270 (+)NCBIChiLan1.0ChiLan1.0
SLC6A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,081,159 - 65,130,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,999,569 - 71,049,402 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,885,756 - 35,935,638 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,990,694 - 55,040,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,990,773 - 55,040,504 (+)Ensemblpanpan1.1panPan2
SLC6A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,319,304 - 60,362,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,318,999 - 60,363,120 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,952,622 - 56,995,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,864,357 - 60,907,590 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,862,947 - 60,909,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,691,521 - 57,734,761 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,709,413 - 58,758,960 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,594,439 - 59,637,674 (-)NCBIUU_Cfam_GSD_1.0
Slc6a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,615,383 - 51,651,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,938,519 - 7,973,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,937,920 - 7,973,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,931,664 - 29,981,372 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1629,931,650 - 29,981,636 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,398,949 - 27,454,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,434,004 - 41,482,568 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,435,387 - 41,483,643 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604734,861,536 - 34,911,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013073307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01036928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000008687   ⟹   ENSHGLP00000008596
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247571,294,064 - 1,332,856 (-)Ensembl
RefSeq Acc Id: XM_013073307   ⟹   XP_012928761
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247571,292,811 - 1,332,868 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012928761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008596
Reference Protein Sequences
RefSeq Acc Id: XP_012928761   ⟸   XM_013073307
- UniProtKB: G5BSD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000008596   ⟸   ENSHGLT00000008687


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006203 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008687 ENTREZGENE
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Na/ntran_symport_noradrenaline UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
NCBI Gene Slc6a2 ENTREZGENE
PANTHER SODIUM-DEPENDENT NORADRENALINE TRANSPORTER UniProtKB/TrEMBL
  SODIUM/CHLORIDE DEPENDENT TRANSPORTER UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PRINTS NANEUSMPORT UniProtKB/TrEMBL
  NORTRANSPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
Superfamily-SCOP SNF-like UniProtKB/TrEMBL
UniProt G5BSD5 ENTREZGENE, UniProtKB/TrEMBL