Smad1 (SMAD family member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Smad1 (SMAD family member 1) Heterocephalus glaber
Analyze
Symbol: Smad1
Name: SMAD family member 1
RGD ID: 18912075
Description: ENCODES a protein that exhibits co-SMAD binding (ortholog); DEAD/H-box RNA helicase binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anti-Mullerian hormone receptor signaling pathway (ortholog); BMP signaling pathway (ortholog); bone development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); COVID-19 (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN chromatin (ortholog); homomeric SMAD protein complex (ortholog); male germ cell nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mothers against decapentaplegic homolog 1; Mothers against decapentaplegic-like protein 1; SMAD family member 1 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248534,444,876 - 4,502,496 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248534,415,816 - 4,503,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IEA)
anti-Mullerian hormone receptor signaling pathway  (ISO)
BMP signaling pathway  (IEA,ISO)
bone development  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cartilage development  (ISO)
cell differentiation  (IEA)
cell population proliferation  (ISO)
DNA-templated transcription  (ISO)
gamete generation  (ISO)
hindbrain development  (ISO)
homeostatic process  (ISO)
inflammatory response  (ISO)
intracellular iron ion homeostasis  (ISO)
kidney development  (ISO)
MAPK cascade  (ISO)
mesodermal cell fate commitment  (ISO)
midbrain development  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of muscle cell differentiation  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoblast fate commitment  (ISO)
positive regulation of cartilage development  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein phosphorylation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (IEA)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA)
ureteric bud development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Smad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248534,444,876 - 4,502,496 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248534,415,816 - 4,503,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
SMAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384145,480,770 - 145,559,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4145,481,194 - 145,559,176 (+)Ensemblhg38GRCh38
GRCh374146,402,458 - 146,480,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,622,401 - 146,699,778 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344146,760,555 - 146,837,928NCBI
Celera4143,730,483 - 143,807,862 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4142,134,622 - 142,210,284 (+)NCBIHuRef
CHM1_14146,379,527 - 146,456,909 (+)NCBICHM1_1
T2T-CHM13v2.04148,798,276 - 148,874,991 (+)NCBIT2T-CHM13v2.0
Smad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,065,024 - 80,126,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl880,065,024 - 80,126,147 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38879,338,395 - 79,399,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,338,395 - 79,399,518 (-)Ensemblmm10GRCm38
MGSCv37881,862,294 - 81,923,367 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36882,234,467 - 82,295,540 (-)NCBIMGSCv36mm8
Celera883,615,361 - 83,676,406 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.56NCBI
Smad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,417,430 - 45,477,962 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1945,417,433 - 45,477,957 (+)EnsemblGRCr8
mRatBN7.21928,513,130 - 28,573,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1935,369,097 - 35,429,185 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,023,176 - 36,083,272 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01938,258,468 - 38,318,560 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01932,182,942 - 32,248,694 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)Ensemblrn6Rnor6.0
Rnor_5.01943,079,695 - 43,145,300 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41930,348,886 - 30,409,345 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1928,023,055 - 28,083,575 (+)NCBICelera
RGSC_v3.11930,353,711 - 30,414,170 (+)NCBI
Cytogenetic Map19q11NCBI
Smad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,361,085 - 1,429,948 (+)Ensembl
ChiLan1.0NW_0049554281,357,398 - 1,429,521 (+)NCBIChiLan1.0ChiLan1.0
SMAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23143,354,683 - 143,433,135 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14143,753,819 - 143,798,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04137,822,269 - 137,899,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14149,481,819 - 149,558,135 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,481,836 - 149,558,135 (+)EnsemblpanPan2panpan1.1
SMAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11544,093,491 - 44,171,177 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1544,095,497 - 44,170,098 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1544,485,533 - 44,563,273 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01544,761,101 - 44,839,209 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1544,763,658 - 44,839,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11544,034,585 - 44,112,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01544,121,557 - 44,199,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01544,386,546 - 44,464,496 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Smad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,145,177 - 46,219,936 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365353,582,489 - 3,657,063 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365353,582,512 - 3,626,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl882,908,527 - 82,968,994 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1882,907,557 - 82,987,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1792,047,273 - 92,123,451 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl792,079,914 - 92,123,429 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603771,693,446 - 71,769,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000265   ⟹   ENSHGLP00000000232
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248534,444,876 - 4,502,496 (+)Ensembl
RefSeq Acc Id: XM_004868910   ⟹   XP_004868967
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248534,415,816 - 4,503,317 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004868967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000232
GenBank Protein JAO03400 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004868967   ⟸   XM_004868910
- UniProtKB: G5C7E2 (UniProtKB/TrEMBL),   G5B7D9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000232   ⟸   ENSHGLT00000000265


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000000265 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
KEGG Report hgl:101725903 UniProtKB/TrEMBL
NCBI Gene Smad1 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt G5B7D9 ENTREZGENE, UniProtKB/TrEMBL
  G5C7E2 ENTREZGENE, UniProtKB/TrEMBL