Hdac6 (histone deacetylase 6) - Rat Genome Database

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Gene: Hdac6 (histone deacetylase 6) Heterocephalus glaber
Analyze
Symbol: Hdac6
Name: histone deacetylase 6
RGD ID: 18906166
Description: ENCODES a protein that exhibits acetylspermidine deacetylase activity (ortholog); alpha-tubulin binding (ortholog); ATPase inhibitor activity (ortholog); INVOLVED IN actin filament organization (ortholog); aggresome assembly (ortholog); axonal transport of mitochondrion (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); cervix uteri carcinoma in situ (ortholog); cholangiocarcinoma (ortholog); FOUND IN aggresome (ortholog); axon (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893608,540 - 628,580 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893608,744 - 627,600 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
aggresome assembly  (ISO)
axonal transport of mitochondrion  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to misfolded protein  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to topologically incorrect protein  (ISO)
cilium disassembly  (ISO)
collateral sprouting  (ISO)
dendritic spine morphogenesis  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
epigenetic regulation of gene expression  (IEA)
erythrocyte enucleation  (ISO)
Hsp90 deacetylation  (ISO)
intracellular protein transport  (ISO)
lysosome localization  (ISO)
mitochondrion localization  (ISO)
negative regulation of aggrephagy  (ISO)
negative regulation of axon extension involved in axon guidance  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of hydrogen peroxide metabolic process  (ISO)
negative regulation of microtubule depolymerization  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of protein-containing complex disassembly  (ISO)
negative regulation of proteolysis  (ISO)
neuron differentiation  (ISO)
peptidyl-lysine deacetylation  (ISO)
polyamine deacetylation  (ISO)
polyubiquitinated misfolded protein transport  (ISO)
positive regulation of cellular response to oxidative stress  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein oligomerization  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of tubulin deacetylation  (ISO)
positive regulation of type 2 mitophagy  (ISO)
protein deacetylation  (ISO)
protein deacylation  (ISO)
protein destabilization  (ISO)
protein polyubiquitination  (ISO)
protein quality control for misfolded or incompletely synthesized proteins  (ISO)
protein-containing complex disassembly  (ISO)
regulation of establishment of protein localization  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of macroautophagy  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of protein stability  (ISO)
response to amphetamine  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to immobilization stress  (ISO)
response to misfolded protein  (ISO)
spermidine deacetylation  (ISO)
tubulin deacetylation  (ISO)
type 2 mitophagy  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hdac6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893608,540 - 628,580 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893608,744 - 627,600 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HDAC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,801,398 - 48,824,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,801,377 - 48,824,982 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,659,805 - 48,683,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,545,431 - 48,568,324 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,416,735 - 48,439,629NCBI
CeleraX52,980,148 - 53,003,041 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,319,662 - 46,343,018 (+)NCBIHuRef
CHM1_1X48,691,631 - 48,714,524 (+)NCBICHM1_1
T2T-CHM13v2.0X48,211,870 - 48,235,478 (+)NCBIT2T-CHM13v2.0
Hdac6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,796,355 - 7,814,284 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,796,359 - 7,814,128 (-)EnsemblGRCm39 Ensembl
GRCm38X7,930,116 - 7,948,047 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,930,120 - 7,947,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,507,248 - 7,525,015 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,087,085 - 7,104,203 (-)NCBIMGSCv36mm8
CeleraX3,521,555 - 3,539,209 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.58NCBI
Hdac6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,222,538 - 17,244,373 (+)NCBIGRCr8
mRatBN7.2X14,550,645 - 14,572,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,551,044 - 14,572,441 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X15,396,185 - 15,417,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,295,473 - 15,316,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,396,895 - 15,417,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,075,029 - 16,096,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,585,852 - 26,606,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,658,892 - 26,659,565 (+)NCBI
CeleraX14,635,909 - 14,657,201 (+)NCBICelera
Cytogenetic MapXq12NCBI
Hdac6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543348,019 - 378,071 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543348,314 - 378,391 (+)NCBIChiLan1.0ChiLan1.0
HDAC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,290,594 - 50,314,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,293,976 - 50,317,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,099,539 - 41,122,650 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,960,181 - 48,982,648 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,960,430 - 48,982,642 (+)Ensemblpanpan1.1panPan2
HDAC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,004,268 - 42,024,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,004,591 - 42,024,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,379,688 - 16,400,160 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,140,437 - 42,160,915 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,140,480 - 42,160,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,126,695 - 42,147,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,114,965 - 42,135,438 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,209,124 - 42,229,594 (+)NCBIUU_Cfam_GSD_1.0
Hdac6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,517,114 - 34,538,029 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721758,181 - 778,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721757,500 - 778,416 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,917,964 - 42,941,887 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,917,911 - 42,941,894 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,858,997 - 47,883,202 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,927,625 - 45,951,636 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,928,092 - 45,952,929 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,407,911 - 11,431,438 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000014855   ⟹   ENSHGLP00000014710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624893608,540 - 628,580 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000014856   ⟹   ENSHGLP00000014711
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624893609,897 - 627,200 (+)Ensembl
RefSeq Acc Id: XM_013068214   ⟹   XP_012923668
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,386 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068215   ⟹   XP_012923669
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,460 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068217   ⟹   XP_012923671
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893608,744 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068218   ⟹   XP_012923672
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,350 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068219   ⟹   XP_012923673
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,257 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068220   ⟹   XP_012923674
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,330 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068221   ⟹   XP_012923675
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,057 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068222   ⟹   XP_012923676
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893608,769 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068223   ⟹   XP_012923677
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,386 - 627,600 (+)NCBI
RefSeq Acc Id: XM_013068226   ⟹   XP_012923680
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893612,036 - 627,600 (+)NCBI
RefSeq Acc Id: XM_021249966   ⟹   XP_021105625
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893608,744 - 627,600 (+)NCBI
RefSeq Acc Id: XM_021249968   ⟹   XP_021105627
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893609,350 - 627,600 (+)NCBI
RefSeq Acc Id: XM_021249969   ⟹   XP_021105628
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893608,745 - 627,600 (+)NCBI
RefSeq Acc Id: XM_021249970   ⟹   XP_021105629
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624893608,745 - 627,600 (+)NCBI
RefSeq Acc Id: XP_012923671   ⟸   XM_013068217
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105625   ⟸   XM_021249966
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S6J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105628   ⟸   XM_021249969
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SC34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105629   ⟸   XM_021249970
- Peptide Label: isoform X4
- UniProtKB: A0AAX6SAX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923676   ⟸   XM_013068222
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923675   ⟸   XM_013068221
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923673   ⟸   XM_013068219
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923674   ⟸   XM_013068220
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923672   ⟸   XM_013068218
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105627   ⟸   XM_021249968
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S6J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923668   ⟸   XM_013068214
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923677   ⟸   XM_013068223
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S6J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923669   ⟸   XM_013068215
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923680   ⟸   XM_013068226
- Peptide Label: isoform X5
- UniProtKB: A0AAX6QMK5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014710   ⟸   ENSHGLT00000014855
Ensembl Acc Id: ENSHGLP00000014711   ⟸   ENSHGLT00000014856


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010523 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014855 ENTREZGENE
  ENSHGLT00000014856 ENTREZGENE
NCBI Gene Hdac6 ENTREZGENE
UniProt A0AAX6QMK5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QRC0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S6J0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SAX7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SC34 ENTREZGENE, UniProtKB/TrEMBL