Frs2 (fibroblast growth factor receptor substrate 2) - Rat Genome Database

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Gene: Frs2 (fibroblast growth factor receptor substrate 2) Heterocephalus glaber
Analyze
Symbol: Frs2
Name: fibroblast growth factor receptor substrate 2
RGD ID: 18905946
Description: ENCODES a protein that exhibits fibroblast growth factor receptor binding (inferred); neurotrophin TRKA receptor binding (inferred); transmembrane receptor protein tyrosine kinase adaptor activity (inferred); INVOLVED IN anterior/posterior axis specification, embryo (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH genetic disease (ortholog); renal cell carcinoma (ortholog); FOUND IN adherens junction (inferred); cell-cell junction (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Frs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381269,470,388 - 69,579,793 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1269,470,349 - 69,579,793 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,864,168 - 69,973,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,150,396 - 68,259,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 341268,150,452 - 68,255,011NCBI
Celera1269,527,782 - 69,637,211 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,913,617 - 67,023,032 (+)NCBIHuRef
CHM1_11269,832,586 - 69,941,996 (+)NCBICHM1_1
T2T-CHM13v2.01269,449,328 - 69,558,701 (+)NCBIT2T-CHM13v2.0
Frs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,905,324 - 116,986,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,905,332 - 116,984,439 (-)EnsemblGRCm39 Ensembl
GRCm3810117,070,127 - 117,148,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,069,427 - 117,148,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710116,507,183 - 116,585,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610116,474,237 - 116,552,584 (-)NCBIMGSCv36mm8
Celera10119,013,278 - 119,091,626 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1065.09NCBI
Frs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,597,182 - 54,678,656 (-)NCBIGRCr8
mRatBN7.2752,711,255 - 52,792,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,711,257 - 52,792,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx754,617,996 - 54,699,472 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,821,102 - 56,902,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,599,002 - 56,680,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,128,506 - 60,210,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,128,508 - 60,210,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,128,589 - 60,210,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,409,863 - 56,490,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1756,435,173 - 56,446,435 (-)NCBI
Celera749,486,845 - 49,568,253 (-)NCBICelera
Cytogenetic Map7q22NCBI
Frs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,843,925 - 9,884,220 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,785,857 - 9,884,220 (+)NCBIChiLan1.0ChiLan1.0
FRS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21077,497,563 - 77,613,316 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11277,493,983 - 77,609,107 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,992,207 - 67,107,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,767,526 - 69,878,293 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,829,435 - 69,878,293 (+)Ensemblpanpan1.1panPan2
FRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11011,445,843 - 11,552,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1011,539,994 - 11,552,890 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1011,377,588 - 11,487,799 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,569,128 - 11,679,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,569,145 - 11,675,626 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11011,436,282 - 11,546,368 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,683,256 - 11,793,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,806,052 - 11,916,601 (+)NCBIUU_Cfam_GSD_1.0
Frs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494546,703,111 - 46,824,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365457,396,023 - 7,407,637 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365457,286,018 - 7,407,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,725,444 - 33,849,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,725,432 - 33,852,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2536,346,044 - 36,385,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11165,097,789 - 65,208,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1165,197,385 - 65,208,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037180,481,351 - 180,595,730 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_004845061   ⟹   XP_004845118
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBI
RefSeq Acc Id: XM_013072332   ⟹   XP_012927786
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475028,224,289 - 28,240,602 (-)NCBI
RefSeq Acc Id: XM_021258546   ⟹   XP_021114205
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBI
RefSeq Acc Id: XM_021258547   ⟹   XP_021114206
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475028,224,289 - 28,359,473 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004845118 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927786 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114205 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA99383 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006420
  ENSHGLP00100002256
Reference Protein Sequences
RefSeq Acc Id: XP_021114206   ⟸   XM_021258547
- UniProtKB: G5AQS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845118   ⟸   XM_004845061
- UniProtKB: G5AQS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114205   ⟸   XM_021258546
- UniProtKB: G5AQS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927786   ⟸   XM_013072332
- UniProtKB: G5AQS3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004690 ENTREZGENE
  ENSHGLG00100001760 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000006501 ENTREZGENE
  ENSHGLT00100002306 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro FRS2_PTB UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101696593 UniProtKB/TrEMBL
NCBI Gene Frs2 ENTREZGENE
PANTHER DOCKING PROTEIN RELATED UniProtKB/TrEMBL
  FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt G5AQS3 ENTREZGENE, UniProtKB/TrEMBL