Dbn1 (drebrin 1) - Rat Genome Database

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Gene: Dbn1 (drebrin 1) Heterocephalus glaber
Analyze
Symbol: Dbn1
Name: drebrin 1
RGD ID: 18904244
Description: ENCODES a protein that exhibits actin filament binding (ortholog); cytoskeletal motor inhibitor activity (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); cell communication by chemical coupling (ortholog); cell communication by electrical coupling (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Down syndrome (ortholog); FOUND IN asymmetric synapse (ortholog); axonal growth cone (ortholog); axonal spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: drebrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,616,423 - 12,632,133 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO)
cell communication by chemical coupling  (IEA,ISO)
cell communication by electrical coupling  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
cytoplasmic sequestering of protein  (IEA)
generation of neurons  (IEA)
in utero embryonic development  (IEA,ISO)
lung alveolus development  (ISO)
maintenance of protein location in cell  (IEA,ISO)
modulation of inhibitory postsynaptic potential  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of muscle filament sliding  (ISO)
nervous system development  (ISO)
neural precursor cell proliferation  (IEA)
neuron projection morphogenesis  (IEA)
positive regulation of axon extension  (IEA,ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of dendritic spine morphogenesis  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of receptor localization to synapse  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of synaptic plasticity  (IEA)
postsynaptic actin cytoskeleton organization  (IEA)
prepulse inhibition  (ISO)
regulation of actin filament polymerization  (IEA,ISO)
regulation of filopodium assembly  (ISO)
regulation of postsynaptic density protein 95 clustering  (ISO)
response to activity  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Dbn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,616,423 - 12,632,133 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DBN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,456,610 - 177,473,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,456,608 - 177,474,401 (-)EnsemblGRCh38hg38GRCh38
GRCh375176,883,611 - 176,900,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,816,220 - 176,833,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 345176,816,219 - 176,832,805NCBI
Celera5171,601,010 - 171,618,030 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,803,862 - 171,820,946 (-)NCBIHuRef
CHM1_15176,316,642 - 176,333,751 (-)NCBICHM1_1
T2T-CHM13v2.05177,999,656 - 178,023,769 (-)NCBIT2T-CHM13v2.0
Dbn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,621,241 - 55,635,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)EnsemblGRCm39 Ensembl
GRCm381355,473,428 - 55,488,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,574,789 - 55,589,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,483,409 - 55,497,790 (-)NCBIMGSCv36mm8
Celera1356,527,471 - 56,542,117 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
Dbn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,155,729 - 9,170,121 (+)NCBIGRCr8
mRatBN7.2179,150,608 - 9,164,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,166,818 - 9,180,807 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,696,845 - 10,710,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,163,206 - 9,177,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,679,511 - 9,693,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,679,628 - 9,693,820 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,788,527 - 11,802,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,194,687 - 15,208,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,194,686 - 15,208,660 (+)NCBI
Celera179,229,222 - 9,243,194 (+)NCBICelera
Cytogenetic Map17p14NCBI
Dbn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,696,266 - 29,705,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,695,442 - 29,705,417 (-)NCBIChiLan1.0ChiLan1.0
DBN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,540,928 - 172,557,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,680,775 - 170,697,165 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,758,316 - 172,774,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,820,791 - 179,833,546 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,820,791 - 179,836,872 (-)Ensemblpanpan1.1panPan2
DBN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,899,969 - 35,913,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,889,392 - 35,912,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,866,175 - 35,880,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,265,157 - 36,279,633 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,240,908 - 36,279,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,090,417 - 36,104,899 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,276,383 - 36,290,861 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,785,850 - 36,800,327 (+)NCBIUU_Cfam_GSD_1.0
Dbn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,710,677 - 122,722,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,735,380 - 1,747,569 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,735,589 - 1,751,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,479,460 - 80,495,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,480,603 - 80,495,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DBN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,468,010 - 79,484,603 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,467,647 - 79,484,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,659,367 - 10,676,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000009313   ⟹   ENSHGLP00000009213
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473312,616,423 - 12,632,133 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000009314   ⟹   ENSHGLP00000009214
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473312,616,560 - 12,631,967 (+)Ensembl
RefSeq Acc Id: XM_004836245   ⟹   XP_004836302
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBI
RefSeq Acc Id: XM_004836246   ⟹   XP_004836303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004836302 (Get FASTA)   NCBI Sequence Viewer  
  XP_004836303 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009213
  ENSHGLP00000009214
GenBank Protein JAN98838 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004836302   ⟸   XM_004836245
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004836303   ⟸   XM_004836246
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J871 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000009213   ⟸   ENSHGLT00000009313
RefSeq Acc Id: ENSHGLP00000009214   ⟸   ENSHGLT00000009314


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006617 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009313 ENTREZGENE
  ENSHGLT00000009314 ENTREZGENE
Gene3D-CATH 3.40.20.10 UniProtKB/TrEMBL
InterPro ADF-H UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Dbn1 ENTREZGENE
PANTHER CORTACTIN AND DREBRIN UniProtKB/TrEMBL
  PTHR10829:SF1 UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/TrEMBL
PROSITE ADF_H UniProtKB/TrEMBL
SMART ADF UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/TrEMBL
UniProt A0A0P6J871 ENTREZGENE, UniProtKB/TrEMBL