Acad8 (acyl-CoA dehydrogenase family member 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Acad8 (acyl-CoA dehydrogenase family member 8) Heterocephalus glaber
Analyze
Symbol: Acad8
Name: acyl-CoA dehydrogenase family member 8
RGD ID: 18903554
Description: ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (inferred); flavin adenine dinucleotide binding (inferred); oxidoreductase activity (inferred); INVOLVED IN carboxylic acid catabolic process (inferred); lipid metabolic process (inferred); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Chromosome 11, Partial Trisomy 11q (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Isobutyryl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248128,814,004 - 8,827,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248128,810,597 - 8,828,664 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Acad8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248128,814,004 - 8,827,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248128,810,597 - 8,828,664 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ACAD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811134,253,568 - 134,265,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11134,253,548 - 134,265,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3711134,123,462 - 134,135,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611133,628,644 - 133,640,959 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411133,628,616 - 133,640,954NCBI
Celera11131,296,297 - 131,308,612 (+)NCBICelera
Cytogenetic Map11q25NCBI
HuRef11130,078,195 - 130,090,510 (+)NCBIHuRef
CHM1_111134,010,170 - 134,022,485 (+)NCBICHM1_1
T2T-CHM13v2.011134,295,413 - 134,307,700 (+)NCBIT2T-CHM13v2.0
Acad8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39926,885,434 - 26,910,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl926,885,431 - 26,910,862 (-)EnsemblGRCm39 Ensembl
GRCm38926,974,138 - 26,999,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl926,974,135 - 26,999,566 (-)EnsemblGRCm38mm10GRCm38
MGSCv37926,781,723 - 26,807,134 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36926,723,581 - 26,748,992 (-)NCBIMGSCv36mm8
Celera924,232,315 - 24,257,730 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map912.0NCBI
Acad8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,641,420 - 33,665,542 (-)NCBIGRCr8
mRatBN7.2825,382,271 - 25,406,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,382,273 - 25,406,414 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx829,424,234 - 29,448,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,718,532 - 27,742,655 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,598,530 - 25,622,652 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0828,023,401 - 28,044,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl828,024,123 - 28,044,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0828,043,131 - 28,064,689 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4826,629,337 - 26,632,170 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera826,870,353 - 26,894,274 (-)NCBICelera
Cytogenetic Map8q13NCBI
Acad8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541235,067,702 - 35,083,889 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541235,067,637 - 35,083,889 (+)NCBIChiLan1.0ChiLan1.0
ACAD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29134,978,240 - 134,990,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111136,077,436 - 136,089,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011129,106,646 - 129,118,773 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111132,964,053 - 132,976,097 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11132,964,071 - 132,976,092 (+)Ensemblpanpan1.1panPan2
ACAD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.15974,673 - 992,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl5976,008 - 992,330 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha51,095,480 - 1,112,953 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.05931,393 - 949,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl5930,833 - 949,214 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.15964,076 - 982,443 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.05964,777 - 982,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.051,002,757 - 1,019,593 (-)NCBIUU_Cfam_GSD_1.0
Acad8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947116,011,700 - 116,030,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366841,575,955 - 1,591,212 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366841,572,386 - 1,591,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl960,807,486 - 60,828,389 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1960,807,405 - 60,828,379 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2967,348,518 - 67,366,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,314,481 - 125,327,045 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,314,492 - 125,327,692 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666043718,399 - 730,915 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001917   ⟹   ENSHGLP00000001871
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248128,814,004 - 8,827,944 (+)Ensembl
RefSeq Acc Id: XM_004862673   ⟹   XP_004862730
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248128,810,597 - 8,828,664 (+)NCBI
RefSeq Acc Id: XM_021242780   ⟹   XP_021098439
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248128,810,597 - 8,824,586 (+)NCBI
RefSeq Acc Id: XM_021242781   ⟹   XP_021098440
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248128,810,597 - 8,828,664 (+)NCBI
RefSeq Acc Id: XR_002388769
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248128,810,597 - 8,828,664 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862730 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098439 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098440 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB03547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000054120
  ENSHGLP00100039858
Reference Protein Sequences
RefSeq Acc Id: XP_004862730   ⟸   XM_004862673
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021098440   ⟸   XM_021242781
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021098439   ⟸   XM_021242780
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000001871   ⟸   ENSHGLT00000001917


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001428 Ensembl, UniProtKB/TrEMBL
  ENSHGLG00100006304 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000049235 UniProtKB/TrEMBL
  ENSHGLT00100084374 UniProtKB/TrEMBL
Gene3D-CATH Acyl-CoA dehydrogenase/oxidase, N-terminal domain UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 2 UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/TrEMBL
InterPro Acyl-CoA_DH_CS UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom_sf UniProtKB/TrEMBL
  IBD UniProtKB/TrEMBL
NCBI Gene Acad8 ENTREZGENE
PANTHER ISOBUTYRYL-COA DEHYDROGENASE UniProtKB/TrEMBL
  ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/TrEMBL
PIRSF HsaA UniProtKB/TrEMBL
PROSITE ACYL_COA_DH_1 UniProtKB/TrEMBL
Superfamily-SCOP Acyl-CoA dehydrogenase C-terminal domain-like UniProtKB/TrEMBL
  Acyl-CoA dehydrogenase NM domain-like UniProtKB/TrEMBL
UniProt G5B2N6_HETGA UniProtKB/TrEMBL