Mmadhc (metabolism of cobalamin associated D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mmadhc (metabolism of cobalamin associated D) Heterocephalus glaber
Analyze
Symbol: Mmadhc
Name: metabolism of cobalamin associated D
RGD ID: 18901804
Description: INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); inherited metabolic disorder (ortholog); methylmalonic aciduria and homocystinuria type cblC (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylmalonic aciduria and homocystinuria type D protein, mitochondrial; methylmalonic aciduria and homocystinuria, cblD type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248662,314,864 - 2,342,079 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248662,314,864 - 2,342,069 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mmadhc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248662,314,864 - 2,342,079 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248662,314,864 - 2,342,069 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MMADHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382149,569,637 - 149,587,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2149,569,637 - 149,587,778 (-)EnsemblGRCh38hg38GRCh38
GRCh372150,426,151 - 150,444,289 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362150,134,397 - 150,152,523 (-)NCBINCBI36Build 36hg18NCBI36
Build 342150,251,659 - 150,269,785NCBI
Celera2144,039,995 - 144,058,186 (-)NCBICelera
Cytogenetic Map2q23.2NCBI
HuRef2142,325,245 - 142,343,436 (-)NCBIHuRef
CHM1_12150,432,065 - 150,450,246 (-)NCBICHM1_1
T2T-CHM13v2.02150,020,083 - 150,038,221 (-)NCBIT2T-CHM13v2.0
Mmadhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39250,169,893 - 50,189,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl250,169,893 - 50,186,813 (-)EnsemblGRCm39 Ensembl
GRCm38250,279,881 - 50,299,021 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl250,279,881 - 50,296,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv37250,135,401 - 50,152,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36250,101,890 - 50,118,686 (-)NCBIMGSCv36mm8
Celera251,952,182 - 51,968,978 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.92NCBI
Mmadhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,117,832 - 55,135,735 (-)NCBIGRCr8
mRatBN7.2334,708,649 - 34,726,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,708,649 - 34,726,771 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx338,102,766 - 38,120,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0346,687,484 - 46,705,415 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0344,478,719 - 44,496,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0335,783,511 - 35,801,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,783,623 - 35,801,614 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0340,897,289 - 40,915,271 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4331,224,132 - 31,242,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1331,120,504 - 31,138,845 (-)NCBI
Celera332,887,861 - 32,905,961 (-)NCBICelera
Cytogenetic Map3q12NCBI
Mmadhc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544015,316,822 - 15,337,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544015,317,877 - 15,338,139 (-)NCBIChiLan1.0ChiLan1.0
MMADHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21325,345,073 - 25,363,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B25,360,062 - 25,380,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B10,278,656 - 10,298,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B153,924,371 - 153,942,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B153,924,371 - 153,942,537 (-)Ensemblpanpan1.1panPan2
MMADHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11951,154,227 - 51,177,950 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1951,154,249 - 51,177,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1951,275,857 - 51,300,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01952,628,133 - 52,652,640 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1952,628,045 - 52,652,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11951,296,784 - 51,321,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01951,405,022 - 51,429,713 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01952,805,790 - 52,830,278 (-)NCBIUU_Cfam_GSD_1.0
Mmadhc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303113,830,468 - 113,846,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646927,771,937 - 27,787,233 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646927,771,741 - 27,804,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMADHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl152,499,154 - 2,520,799 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1152,499,080 - 2,517,361 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2151,931,294 - 1,949,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMADHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,999,856 - 35,019,575 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,999,067 - 35,019,389 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040164,518,012 - 164,535,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016429   ⟹   ENSHGLP00000016260
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248662,314,864 - 2,342,079 (-)Ensembl
RefSeq Acc Id: XM_004870002   ⟹   XP_004870059
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248662,314,864 - 2,342,069 (-)NCBI
RefSeq Acc Id: XM_013067536   ⟹   XP_012922990
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248662,316,086 - 2,342,029 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004870059 (Get FASTA)   NCBI Sequence Viewer  
  XP_012922990 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016260
  ENSHGLP00100008392
GenBank Protein JAO00993 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004870059   ⟸   XM_004870002
- UniProtKB: A0A0P6JWQ6 (UniProtKB/TrEMBL),   G5B7S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012922990   ⟸   XM_013067536
- UniProtKB: A0A0P6JWQ6 (UniProtKB/TrEMBL),   G5B7S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016260   ⟸   ENSHGLT00000016429


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011653 Ensembl, ENTREZGENE
  ENSHGLG00100006236 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000016429 ENTREZGENE
  ENSHGLT00100008491 UniProtKB/TrEMBL
InterPro MMADHC UniProtKB/TrEMBL
KEGG Report hgl:101715098 UniProtKB/TrEMBL
NCBI Gene Mmadhc ENTREZGENE
PANTHER COBALAMIN TRAFFICKING PROTEIN CBLD UniProtKB/TrEMBL
  PTHR13192 UniProtKB/TrEMBL
Pfam MMADHC UniProtKB/TrEMBL
UniProt A0A0P6JWQ6 ENTREZGENE, UniProtKB/TrEMBL
  G5B7S8 ENTREZGENE, UniProtKB/TrEMBL