Tmem259 (transmembrane protein 259) - Rat Genome Database

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Pathways
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Gene: Tmem259 (transmembrane protein 259) Heterocephalus glaber
Analyze
Symbol: Tmem259
Name: transmembrane protein 259
RGD ID: 18900580
Description: INVOLVED IN positive regulation of ERAD pathway (inferred); response to endoplasmic reticulum stress (inferred); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); intracellular organelle (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: membralin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,606,339 - 7,614,107 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,606,177 - 7,614,644 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Tmem259
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,606,339 - 7,614,107 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,606,177 - 7,614,644 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TMEM259
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,009,653 - 1,021,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,009,648 - 1,021,179 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,009,652 - 1,021,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619960,650 - 972,141 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419960,649 - 972,114NCBI
Celera19941,988 - 953,479 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19782,787 - 794,267 (-)NCBIHuRef
CHM1_1191,008,804 - 1,020,294 (-)NCBICHM1_1
T2T-CHM13v2.019972,322 - 983,792 (-)NCBIT2T-CHM13v2.0
Tmem259
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,812,954 - 79,820,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,810,782 - 79,820,164 (-)EnsemblGRCm39 Ensembl
GRCm381079,977,120 - 79,984,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,974,948 - 79,984,330 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,439,865 - 79,447,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,380,249 - 79,387,291 (-)NCBIMGSCv36mm8
Celera1080,991,927 - 80,999,137 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tmem259
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,374,804 - 10,381,566 (+)NCBIGRCr8
mRatBN7.279,724,196 - 9,730,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,722,485 - 9,730,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,606,557 - 12,613,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,481,879 - 14,488,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,343,077 - 12,349,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,771,239 - 12,777,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,771,227 - 12,779,862 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,940,961 - 12,947,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,236,953 - 11,244,044 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,237,414 - 11,244,044 (+)NCBI
Celera77,899,960 - 7,906,553 (+)NCBICelera
Cytogenetic Map7q11NCBI
Tmem259
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,852,278 - 6,859,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,856,609 - 6,859,948 (+)NCBIChiLan1.0ChiLan1.0
TMEM259
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,339,668 - 5,351,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,578,967 - 4,590,546 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl19983,507 - 994,212 (-)Ensemblpanpan1.1panPan2
TMEM259
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,695,004 - 57,703,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,695,002 - 57,749,891 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,497,098 - 57,505,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,437,023 - 58,445,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,437,018 - 58,445,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,492,365 - 57,500,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,971,883 - 57,980,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,174,902 - 58,183,421 (+)NCBIUU_Cfam_GSD_1.0
Tmem259
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,385,339 - 217,394,323 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588441,135 - 449,444 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588440,460 - 449,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM259
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,393,611 - 77,402,262 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,393,577 - 77,402,266 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,595,383 - 77,604,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM259
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16766,097 - 777,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6765,587 - 777,399 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,142,463 - 8,153,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026038   ⟹   ENSHGLP00000025809
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248287,606,339 - 7,614,107 (+)Ensembl
RefSeq Acc Id: XM_004865986   ⟹   XP_004866043
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248287,606,180 - 7,614,644 (+)NCBI
RefSeq Acc Id: XM_021244862   ⟹   XP_021100521
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248287,606,177 - 7,614,644 (+)NCBI
RefSeq Acc Id: XM_021244863   ⟹   XP_021100522
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248287,606,180 - 7,614,644 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004866043 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100521 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000025809
Reference Protein Sequences
RefSeq Acc Id: XP_021100521   ⟸   XM_021244862
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004866043   ⟸   XM_004865986
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021100522   ⟸   XM_021244863
- Peptide Label: isoform X3
- UniProtKB: G5C5Y2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000025809   ⟸   ENSHGLT00000026038


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018370 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026038 ENTREZGENE
InterPro Membralin UniProtKB/TrEMBL
NCBI Gene Tmem259 ENTREZGENE
PANTHER MEMBRALIN UniProtKB/TrEMBL
  MEMBRALIN/KINETOCHORE PROTEIN NUF2 UniProtKB/TrEMBL
Pfam Membralin UniProtKB/TrEMBL
UniProt G5C5Y2 ENTREZGENE, UniProtKB/TrEMBL