Ksr2 (kinase suppressor of ras 2) - Rat Genome Database

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Gene: Ksr2 (kinase suppressor of ras 2) Heterocephalus glaber
Analyze
Symbol: Ksr2
Name: kinase suppressor of ras 2
RGD ID: 18900129
Description: ENCODES a protein that exhibits MAP-kinase scaffold activity (ortholog); mitogen-activated protein kinase kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of cold-induced thermogenesis (ortholog); positive regulation of MAPK cascade (ortholog); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH genetic disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); morbid obesity (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474715,493,281 - 15,916,052 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,492,312 - 15,931,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
plasma membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ksr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474715,493,281 - 15,916,052 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,492,312 - 15,931,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,453,012 - 117,968,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12117,453,012 - 117,968,990 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,890,817 - 118,406,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,375,222 - 116,777,724 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412116,370,185 - 116,756,061NCBI
Celera12117,521,406 - 118,036,368 (-)NCBICelera
Cytogenetic Map12q24.22-q24.23NCBI
HuRef12114,899,825 - 115,416,596 (-)NCBIHuRef
CHM1_112117,858,453 - 118,373,654 (-)NCBICHM1_1
T2T-CHM13v2.012117,440,139 - 117,956,270 (-)NCBIT2T-CHM13v2.0
Ksr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395117,552,067 - 117,906,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,552,036 - 117,913,068 (+)EnsemblGRCm39 Ensembl
GRCm385117,414,002 - 117,767,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,414,000 - 117,775,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv375117,864,009 - 118,213,329 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365117,675,030 - 117,816,972 (+)NCBIMGSCv36mm8
MGSCv365115,410,053 - 115,812,068 (+)NCBIMGSCv36mm8
Celera5114,504,419 - 114,853,593 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.88NCBI
Ksr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,462,579 - 44,848,555 (-)NCBIGRCr8
mRatBN7.21238,802,796 - 39,187,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,802,004 - 39,188,375 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01244,531,376 - 44,911,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,536,293 - 44,911,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,352,196 - 46,732,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,998,030 - 40,376,125 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1240,461,342 - 40,832,198 (-)NCBICelera
Cytogenetic Map12q16NCBI
Ksr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,374,729 - 13,773,392 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,375,306 - 13,777,681 (+)NCBIChiLan1.0ChiLan1.0
KSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210125,515,275 - 126,033,632 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112125,528,292 - 126,029,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012115,038,344 - 115,548,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112118,416,905 - 118,926,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,420,483 - 118,925,686 (-)Ensemblpanpan1.1panPan2
KSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,986,172 - 14,394,236 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,987,827 - 14,395,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,980,199 - 14,427,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02614,246,948 - 14,695,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,248,572 - 14,656,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,208,068 - 14,660,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,286,011 - 14,732,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,321,636 - 14,768,099 (-)NCBIUU_Cfam_GSD_1.0
Ksr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,331,733 - 154,693,702 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,785,718 - 5,141,609 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,786,148 - 5,146,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1434,676,164 - 35,089,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11434,675,349 - 35,090,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,050,362 - 37,325,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,784,275 - 113,307,935 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11112,784,728 - 113,084,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037131,800,747 - 132,308,761 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000023275   ⟹   ENSHGLP00000023060
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474715,493,281 - 15,916,052 (+)Ensembl
RefSeq Acc Id: XM_004843700   ⟹   XP_004843757
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474715,492,928 - 15,931,358 (+)NCBI
RefSeq Acc Id: XM_013071742   ⟹   XP_012927196
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474715,492,928 - 15,931,358 (+)NCBI
RefSeq Acc Id: XM_013071743   ⟹   XP_012927197
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474715,492,312 - 15,931,358 (+)NCBI
RefSeq Acc Id: XM_013071744   ⟹   XP_012927198
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474715,492,928 - 15,916,052 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004843757 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927196 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927197 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023060
Reference Protein Sequences
RefSeq Acc Id: XP_012927197   ⟸   XM_013071743
- Peptide Label: isoform X1
- UniProtKB: G5AKT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927196   ⟸   XM_013071742
- Peptide Label: isoform X1
- UniProtKB: G5AKT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843757   ⟸   XM_004843700
- Peptide Label: isoform X3
- UniProtKB: G5AKT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927198   ⟸   XM_013071744
- Peptide Label: isoform X2
- UniProtKB: G5AKT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000023060   ⟸   ENSHGLT00000023275


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016442 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023275 ENTREZGENE
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  6.10.140.1120 UniProtKB/TrEMBL
  Transcription Factor, Ets-1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  KSR_SAM-like_dom UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAM_KSR1_N UniProtKB/TrEMBL
  SAM_KSR1_N_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Ksr2 ENTREZGENE
PANTHER KINASE SUPPRESSOR OF RAS 2 UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_KSR1 UniProtKB/TrEMBL
  SAM_KSR1_N UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Cysteine-rich domain UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt G5AKT0 ENTREZGENE, UniProtKB/TrEMBL