SLC9A5 (solute carrier family 9 member A5) - Rat Genome Database

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Gene: SLC9A5 (solute carrier family 9 member A5) Chlorocebus sabaeus
Analyze
Symbol: SLC9A5
Name: solute carrier family 9 member A5
RGD ID: 18794409
Description: ENCODES a protein that exhibits sodium:proton antiporter activity (ortholog); INVOLVED IN proton transmembrane transport (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); end stage renal disease (ortholog); genetic disease (ortholog); FOUND IN focal adhesion (inferred); membrane (inferred); neuron spine (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/hydrogen exchanger 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,181,229 - 60,207,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,182,190 - 60,206,523 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,155 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC9A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,181,229 - 60,207,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,182,190 - 60,206,523 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,155 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SLC9A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,248,979 - 67,272,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,237,683 - 67,272,191 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,282,882 - 67,306,094 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,840,356 - 65,863,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 341665,840,353 - 65,863,594NCBI
Celera1651,791,089 - 51,814,319 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,155,929 - 53,179,176 (+)NCBIHuRef
CHM1_11668,690,183 - 68,713,453 (+)NCBICHM1_1
T2T-CHM13v2.01673,043,264 - 73,066,486 (+)NCBIT2T-CHM13v2.0
Slc9a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,074,782 - 106,095,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,075,475 - 106,096,513 (+)EnsemblGRCm39 Ensembl
GRCm388105,348,156 - 105,369,881 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,348,843 - 105,369,881 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,872,158 - 107,893,781 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,237,387 - 108,259,010 (+)NCBIMGSCv36mm8
Celera8109,571,406 - 109,593,028 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Slc9a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,135,973 - 50,156,833 (+)NCBIGRCr8
mRatBN7.21933,225,481 - 33,246,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,226,816 - 33,246,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,042,419 - 40,062,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,695,745 - 40,715,832 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,984,735 - 43,004,818 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,304,034 - 37,325,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,305,248 - 37,325,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,169,385 - 48,190,757 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,164,590 - 35,184,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,169,470 - 35,189,558 (+)NCBI
Celera1932,655,246 - 32,675,354 (+)NCBICelera
Cytogenetic Map19q12NCBI
Slc9a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,359,468 - 9,379,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,359,468 - 9,379,959 (-)NCBIChiLan1.0ChiLan1.0
SLC9A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,767,254 - 76,801,785 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,679,840 - 82,714,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,582,950 - 47,617,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,983,416 - 67,006,938 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,983,611 - 67,005,957 (+)Ensemblpanpan1.1panPan2
SLC9A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,103,153 - 82,128,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,108,097 - 82,128,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,092,926 - 82,117,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,538,580 - 82,563,342 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,543,783 - 82,563,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,364,683 - 82,389,439 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,050,260 - 82,074,993 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,689,504 - 82,714,260 (-)NCBIUU_Cfam_GSD_1.0
Slc9a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,856,418 - 41,878,851 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,711,442 - 17,732,658 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,711,025 - 17,732,696 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,884,592 - 27,904,075 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,883,163 - 27,904,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,150,465 - 25,171,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Slc9a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474619,051,515 - 19,074,076 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474619,051,508 - 19,074,103 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 30
Low 36 15 30
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000001882   ⟹   ENSCSAP00000000217
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl560,182,190 - 60,206,523 (-)Ensembl
RefSeq Acc Id: XM_007993975   ⟹   XP_007992166
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1560,181,229 - 60,207,907 (-)NCBI
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007993976   ⟹   XP_007992167
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1560,181,229 - 60,207,907 (-)NCBI
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007993977   ⟹   XP_007992168
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1560,181,229 - 60,207,913 (-)NCBI
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038008358   ⟹   XP_037864286
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604722,934,265 - 22,958,660 (-)NCBI
RefSeq Acc Id: XM_038008359   ⟹   XP_037864287
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,074 (-)NCBI
RefSeq Acc Id: XM_038008360   ⟹   XP_037864288
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604722,934,265 - 22,960,074 (-)NCBI
RefSeq Acc Id: XM_038008361   ⟹   XP_037864289
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604722,935,513 - 22,960,155 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007992168   ⟸   XM_007993977
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007992167   ⟸   XM_007993976
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007992166   ⟸   XM_007993975
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QV28 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000217   ⟸   ENSCSAT00000001882
RefSeq Acc Id: XP_037864288   ⟸   XM_038008360
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037864287   ⟸   XM_038008359
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037864286   ⟸   XM_038008358
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037864289   ⟸   XM_038008361
- Peptide Label: isoform X7


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001882.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/TrEMBL
  Na/H_exchanger_3/5 UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/TrEMBL
KEGG Report csab:103233282 UniProtKB/TrEMBL
NCBI Gene SLC9A5 ENTREZGENE
PANTHER PTHR10110 UniProtKB/TrEMBL
  SODIUM/HYDROGEN EXCHANGER 5 UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/TrEMBL
PRINTS NAHEXCHNGR UniProtKB/TrEMBL
  NAHEXCHNGR3 UniProtKB/TrEMBL
UniProt A0A0D9QV28 ENTREZGENE, UniProtKB/TrEMBL