PARL (presenilin associated rhomboid like)

Gene: PARL (presenilin associated rhomboid like) Chlorocebus sabaeus

Analyze

Symbol:

PARL

Name:

presenilin associated rhomboid like

RGD ID:

18794301

Description:

ENCODES a protein that exhibits endopeptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN neuron differentiation (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH 3-Methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); breast carcinoma (ortholog); Cachexia (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

presenilins-associated rhomboid-like protein, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,536,556 - 5,589,522 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	5,536,610 - 5,590,825 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	14,318,952 - 14,371,951 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Methylcrotonyl-CoA carboxylase 1 deficiency (ISO)

breast carcinoma (ISO)

Cachexia (ISO)

congenital disorder of glycosylation Id (ISO)

coronary artery disease (ISO)

Currarino syndrome (ISO)

genetic disease (ISO)

hyperinsulinism (ISO)

Insulin Resistance (ISO)

Leber hereditary optic neuropathy (ISO)

Leigh disease (ISO)

leprosy (ISO)

myopia (ISO)

transient cerebral ischemia (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

membrane protein proteolysis (IEA)

mitochondrial fusion (IEA)

negative regulation of intrinsic apoptotic signaling pathway (IEA)

negative regulation of release of cytochrome c from mitochondria (IEA)

neuron differentiation (ISO)

protein processing (IEA)

proteolysis (IEA)

regulation of mitochondrion organization (IEA)

regulation of mitophagy (IEA)

regulation of protein targeting to mitochondrion (IEA)

regulation of proteolysis (IEA)

regulation of reactive oxygen species metabolic process (IEA)

response to nutrient levels (ISO)

signal peptide processing (IEA)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IEA)

mitochondrion (IEA)

Molecular Function

endopeptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondrial autophagy pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PARL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,536,556 - 5,589,522 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	5,536,610 - 5,590,825 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	14,318,952 - 14,371,951 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PARL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	183,826,489 - 183,884,880 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	183,829,271 - 183,884,933 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	183,547,059 - 183,602,668 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	185,029,867 - 185,085,387 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	185,029,881 - 185,085,356	NCBI
Celera	3	181,990,550 - 182,046,014 (-)	NCBI		Celera
Cytogenetic Map	3	q27.1	NCBI
HuRef	3	180,956,508 - 181,012,355 (-)	NCBI		HuRef
CHM1_1	3	183,511,499 - 183,567,008 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	186,635,981 - 186,694,605 (-)	NCBI		T2T-CHM13v2.0

Parl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	20,098,570 - 20,121,090 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	20,098,568 - 20,121,137 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	20,279,820 - 20,302,395 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	20,279,818 - 20,302,387 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	20,279,893 - 20,302,435 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	20,193,363 - 20,215,905 (-)	NCBI		MGSCv36	mm8
Celera	16	20,843,305 - 20,865,847 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	12.4	NCBI

Parl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	94,097,559 - 94,124,915 (+)	NCBI		GRCr8
mRatBN7.2	11	80,594,059 - 80,620,506 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	80,593,192 - 80,620,506 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	89,317,103 - 89,343,416 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	81,970,532 - 81,996,820 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	81,031,594 - 81,057,895 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	84,517,368 - 84,544,463 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	84,517,368 - 84,544,462 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	87,581,642 - 87,607,939 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,836,666 - 82,864,977 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	82,894,267 - 82,922,572 (+)	NCBI
Celera	11	79,434,291 - 79,460,794 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Parl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	23,548,672 - 23,582,137 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	23,549,125 - 23,581,782 (+)	NCBI	ChiLan1.0	ChiLan1.0

PARL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	181,697,652 - 181,757,265 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	181,703,277 - 181,761,981 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	180,862,434 - 180,921,197 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	189,032,605 - 189,088,091 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	189,032,816 - 189,088,036 (-)	Ensembl	panpan1.1		panPan2

PARL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	16,790,049 - 16,837,557 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	16,781,139 - 16,837,545 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	20,877,392 - 20,924,904 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	16,697,285 - 16,744,859 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	16,697,285 - 16,744,840 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	16,735,526 - 16,783,030 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	16,731,170 - 16,778,655 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	16,960,810 - 17,008,629 (-)	NCBI		UU_Cfam_GSD_1.0

Parl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	119,853,920 - 119,901,118 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	5,945,635 - 5,993,143 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936578	5,945,765 - 5,992,972 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	121,758,738 - 121,813,638 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	121,758,734 - 121,813,679 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	131,193,528 - 131,248,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Parl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	72,642,925 - 72,683,820 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	72,642,828 - 72,683,820 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36		43
Low		20	17
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007971945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000011539 ⟹ ENSCSAP00000009606

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	15	5,536,610 - 5,590,825 (+)	Ensembl

RefSeq Acc Id:

XM_007971945 ⟹ XP_007970136

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	5,536,556 - 5,589,522 (+)	NCBI
Vero_WHO_p1.0	NW_023666063	14,318,952 - 14,371,951 (+)	NCBI

Sequence:

show sequence

GTTGCGCAGCTGGGGTGGGTAAGGTCAGGCCATGGTGGGGCAGAGGTTGGGAAGATGGCGTGGC
GAGGCTGGGCGCAGAGAGGCTGGGGCTGTGGCCAGGCATGGGCTGTGTCGGTGGACGGCCGCAG
CTGCGAGGAGCTCACTGCGGCCCTAGCCCCGCAGCGGCTGCTTGGACGCAGGTTTAACTTCTTT
ATTCAGCAAAAATGCGGATTCAGAAAAGCACCCAGGAAGGTTGAACCTCGAAGATCAGACACAG
GGACAAGTGGTGAAGCATACAGGAGAAGTGCTTTGATTCCTCCTGTGGAAGAAACAGTCTTTTA
TCCGTCTCCGTATCCTATAAGGAGTCTCATAAAACCTTTGTTTTTTACTGTTGGGTTTACAGGC
TGTGCATTTGGATCAGCTGCTATTTGGCAATATGAATCACTGAAATCCAGGGTCCAGAGTTATT
TTGATGGTATTAAAGCTGATTGGTTGGATAGCATAAGACCACAAAAAGAAGGAGACTTCAGAAA
GGAGATTAACAAGTGGTGGAATAACCTAAGTGATGGCCAGCGGACTGTGACAGGTATTATAGCT
GCAAATGTCCTTGTATTCTGTTTATGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATATT
TCACATCGAATCCAGCCTCAAAAGTCCTTTGTTCTCCAATGTTGCTGTCAACATTCAGCCATTT
CTCCTTATTTCACATGGCGGCAAATATGTACGTTTTGTGGAGCTTCTCTTCCAGCATAGTGAAT
ATTCTGGGTCAAGAGCAGTTCATGGCATTGTACCTATCTGCAGGTGTTATTTCCAATTTTGTCA
GTTACGTGGGTAAAGTTGCCACAGGAAGATACGGACCATCACTCGGTGCATCTGGCGCCATCAT
GACGGTCCTCGCAGCTGTCTGCACTAAGATCCCAGAAGGGAGGCTTGCCATTATTTTCCTTCCG
ATGTTCACGTTCACAGCAGGGAATGCCCTGAAAGCCATTATCGCCATGGATACAGCAGGAATGA
TCCTGGGATGGAAATTTTTTGATCATGCAGCACATCTTGGGGGAGCTCTTTTTGGAATATGGTA
TGTTACTTATGGTCATGAACTGATTTGGAAGAACAGGGAACCTCTAGTGAAAATCTGGCATGAA
ATAAGGACTAATGGCCCCAAAAAAGGAGGTGGCACTAAGTAAAACTGGGGTTGGACAGTAATGA
TGCATCTGGTCCATGACGCCTGAGAGCCCCAGAGACACCGGCCCCAGAGTGACCATGGCTGTGC
TCCCGCCTGGAAGATGCCAGCATCTGGCCTCCCAGTGTTTTCAGCTGCGCCCCCCAGTCTGTCT
TTTTAGAAGGTGAATGATGATAAAGTTGTGAAATAAAGGTTTCTATCTAGTTTGTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007970136	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009606
	ENSCSAP00000009606.1

RefSeq Acc Id:	XP_007970136 ⟸ XM_007971945
- UniProtKB:	A0A0D9RLW7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000009606 ⟸ ENSCSAT00000011539

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013473	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011539.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1540.10	UniProtKB/TrEMBL
InterPro	Peptidase_S54_rhomboid_dom	UniProtKB/TrEMBL
	Rhomboid-like_sf	UniProtKB/TrEMBL
KEGG Report	csab:103221155	UniProtKB/TrEMBL
NCBI Gene	PARL	ENTREZGENE
PANTHER	PRESENILINS-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL	UniProtKB/TrEMBL
	RHOMBOID PROTEASE	UniProtKB/TrEMBL
Pfam	Rhomboid	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144091	UniProtKB/TrEMBL
UniProt	A0A0D9RLW7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

RGD Manual Annotations