SOX15 (SRY-box transcription factor 15)

Gene: SOX15 (SRY-box transcription factor 15) Chlorocebus sabaeus

Analyze

Symbol:

SOX15

Name:

SRY-box transcription factor 15

RGD ID:

18792572

Description:

ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell differentiation (ortholog); myoblast development (ortholog); negative regulation of striated muscle tissue development (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); common variable immunodeficiency (ortholog); congenital disorder of glycosylation If (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein SOX-15; SRY-box 15

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,965,969 - 6,967,975 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,962,350 - 6,967,799 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,440,279 - 14,442,829 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

common variable immunodeficiency (ISO)

congenital disorder of glycosylation If (ISO)

congenital myasthenic syndrome 2A (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

Li-Fraumeni syndrome (ISO)

polycystic ovary syndrome (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure morphogenesis (IEA)

cell differentiation (IEA,ISO)

myoblast development (IEA,ISO)

negative regulation of striated muscle tissue development (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of G0 to G1 transition (IEA)

positive regulation of myoblast proliferation (IEA)

positive regulation of satellite cell activation involved in skeletal muscle regeneration (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

skeletal muscle tissue regeneration (IEA,ISO)

trophoblast giant cell differentiation (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

transcription regulator complex (IEA)

Molecular Function

chromatin binding (IEA)

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SOX15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,965,969 - 6,967,975 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,962,350 - 6,967,799 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,440,279 - 14,442,829 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SOX15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,588,178 - 7,590,094 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,588,178 - 7,590,094 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,491,496 - 7,493,412 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,432,222 - 7,434,212 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,432,221 - 7,434,212	NCBI
Celera	17	7,517,821 - 7,519,811 (-)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,385,660 - 7,387,650 (-)	NCBI		HuRef
CHM1_1	17	7,500,429 - 7,502,419 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,492,428 - 7,494,344 (-)	NCBI		T2T-CHM13v2.0

Sox15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,545,863 - 69,547,553 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,546,140 - 69,547,553 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,655,037 - 69,656,727 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,655,314 - 69,656,727 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,468,875 - 69,470,123 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	69,471,568 - 69,472,816 (+)	NCBI		MGSCv36	mm8
MGSCv36	11	70,239,480 - 70,240,728 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.86	NCBI

Sox15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,871,793 - 54,873,497 (+)	NCBI		GRCr8
mRatBN7.2	10	54,373,045 - 54,374,749 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,372,403 - 54,376,591 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	59,035,680 - 59,037,384 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,524,232 - 58,525,936 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,031,837 - 54,033,541 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,260,514 - 56,263,503 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,260,514 - 56,263,503 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,006,152 - 56,009,141 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,473,056 - 56,476,045 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,486,448 - 56,487,721 (+)	NCBI
Celera	10	53,528,127 - 53,531,116 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Sox15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,333,643 - 9,335,498 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,333,620 - 9,335,498 (+)	NCBI	ChiLan1.0	ChiLan1.0

SOX15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,182,906 - 15,185,226 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,148,974 - 17,151,038 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,619,804 - 7,621,791 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,606,086 - 7,608,632 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,606,086 - 7,608,632 (-)	Ensembl	panpan1.1		panPan2

SOX15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,507,869 - 32,509,763 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,508,074 - 32,509,333 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,647,372 - 32,649,216 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,613,127 - 32,614,971 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,613,307 - 32,614,566 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,580,671 - 32,582,515 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,537,129 - 32,538,973 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,716,245 - 32,718,089 (-)	NCBI		UU_Cfam_GSD_1.0

Sox15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,391,690 - 47,393,612 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	861,223 - 867,850 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	865,878 - 868,241 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOX15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	52,882,840 - 52,885,785 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,288,402 - 55,291,398 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Sox15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,202,988 - 10,204,358 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,202,988 - 10,204,808 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	11		2
Low	25	20	58
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008010166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000009477 ⟹ ENSCSAP00000007593

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	6,962,350 - 6,967,799 (-)	Ensembl

RefSeq Acc Id:

XM_008010166 ⟹ XP_008008357

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	6,965,969 - 6,967,975 (-)	NCBI
Vero_WHO_p1.0	NW_023666059	14,440,279 - 14,442,829 (+)	NCBI

Sequence:

show sequence

TTAAGGAGGTGCAGTGTTCTGGGAGGGCCAGGGGCGGAGTCAGTCTTTAAAAGCTGTTCCCAGG
GCTGGCCCGCCTGCCACAAACGCTGAGCCCAGGTGGGAGAGTTCTGGGTCATCCGCGCCTGGCA
GCTGCGGGAACTCCGGAGACCACAAAGCGGTTTATGGTTTTCCCCCTCCACGGAAGGTCGGTCT
GATCGCAACTGCGGGTCGGGGAGAGGGACCGGGGGGTCCCCCCAGTCAGTAGGCCTCAGAGCAG
CACCTCTTCAGTGCCGGGGCATCAGACAGCGGATTTTGCATTCGACTCTCCCCAAAGTGTGCCG
AACTGGTTGGAAGCAAAGGCTCTAGTTTAAGCTCTGGGCTTGGGGATAAAATATACTTTTTAAA
GACCCAAGTTCCTCAGCAACGACTCCAGACTGGGAAGACCCCTCCATTTTCAGGATCGACGCTT
CACGTTGAGGGGAGGGCATTCAGGACGCCCTCTTAAGGCTTCTCCCAACCCATGGCGCTACCGG
GCTCCTCACAGGACCAGGCCTGGAGCCTGGAGCCTCCTGCTCCCACGGCTTCTGCGTCTTCATC
TTCGGGACCCCAGGAGCGGGAGGGCGCTGGGAGCCCCGCGGCCCCCGGGGCGCTGCCCCTGGAG
AAGGTGAAGCGGCCCATGAACGCGTTCATGGTGTGGAGCTCCGCTCAGCGCCGCCAGATGGCGC
AGCAGAACCCCAAGATGCACAACTCTGAGATCTCCAAGCGCCTGGGCGCGCAGTGGAAGCTGCT
GGACGAGGACGAGAAGCGGCCCTTCGTGGAGGAGGCCAAGCGGCTCCGCGCCCGGCACCTGCGC
GACTACCCCGACTACAAGTACCGCCCTCGGCGCAAGGCCAAGAGCTCGGGCGCCGGACCTTCCC
GCTGCGGACAGGGAAGAGGTAGCCTGGCCGGCGGCGGCGCGATCTGGGGGCCGGGGTACGCGAC
CACCCAACCTAGCAGAGGCTTTGGGTACAGACCCCCCAACTACTCGACAGCCTACCTGCCTGGC
AGCTATGGCTCTTCCCACTGCAAACTGGAGGCCCCCTCATCGTGCTCCCTCCCTCAGAGTGACC
CTAGGCTCCAGGGGGAGCTGCTGCCCCCCTATACCCACTACCTGCCCCCTGGCTCTCCCACTCC
ATACAATCCTCCCCTTTCTGGTGCCCCCATGCCCCTAACCCACCTCTAACTCTCGTGGACTCAG
ACCTCACCGGACGTGCCTCATCCTTTTTTAATCCAGCAGCATCCCCTACCCCAGGCTGTCAACC
CTTTCTCACGTTGGACTACAGTGCAGACGCCGCCTGCAGTCCTCCCACGAAAGCCAGGGAGAGC
CGCACAACACAGTTATATTTTTGGTAGTATTAAACACAGTTTTGTATTATTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008008357	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007593
	ENSCSAP00000007593.1

RefSeq Acc Id:	XP_008008357 ⟸ XM_008010166
- UniProtKB:	A0A0D9RG54 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000007593 ⟸ ENSCSAT00000009477

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011393	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009477.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
InterPro	HMG_box_dom	UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103242310	UniProtKB/TrEMBL
NCBI Gene	SOX15	ENTREZGENE
PANTHER	PTHR10270:SF45	UniProtKB/TrEMBL
	SOX TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/TrEMBL
PROSITE	HMG_BOX_2	UniProtKB/TrEMBL
SMART	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47095	UniProtKB/TrEMBL
UniProt	A0A0D9RG54	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD