NNT (nicotinamide nucleotide transhydrogenase) - Rat Genome Database

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Gene: NNT (nicotinamide nucleotide transhydrogenase) Chlorocebus sabaeus
Analyze
Symbol: NNT
Name: nicotinamide nucleotide transhydrogenase
RGD ID: 18791273
Description: ENCODES a protein that exhibits NADP binding (inferred); oxidoreductase activity (inferred); proton-translocating NAD(P)+ transhydrogenase activity (inferred); INVOLVED IN cell redox homeostasis (ortholog); cellular oxidant detoxification (ortholog); intracellular oxygen homeostasis (ortholog); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD(P) transhydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,377,979 - 42,476,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,384,435 - 42,477,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607132,851,165 - 32,963,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NNT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,377,979 - 42,476,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,384,435 - 42,477,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607132,851,165 - 32,963,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NNT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38543,602,675 - 43,707,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl543,602,692 - 43,707,405 (+)EnsemblGRCh38hg38GRCh38
GRCh37543,602,777 - 43,707,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36543,638,548 - 43,741,425 (+)NCBINCBI36Build 36hg18NCBI36
Build 34543,639,063 - 43,741,091NCBI
Celera543,495,188 - 43,598,076 (+)NCBICelera
Cytogenetic Map5p12NCBI
HuRef543,555,411 - 43,658,307 (+)NCBIHuRef
CHM1_1543,604,210 - 43,707,124 (+)NCBICHM1_1
T2T-CHM13v2.0543,849,920 - 43,961,029 (+)NCBIT2T-CHM13v2.0
Nnt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913119,472,063 - 119,545,793 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13119,471,984 - 119,545,533 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl13119,472,064 - 119,545,488 (-)EnsemblGRCm39 Ensembl
GRCm3813119,335,527 - 119,409,257 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,335,448 - 119,408,997 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,335,528 - 119,408,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713120,124,334 - 120,197,945 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613120,453,190 - 120,527,884 (-)NCBIMGSCv36mm8
Celera13123,765,363 - 123,860,935 (-)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.21NCBI
Nnt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,144,157 - 53,237,857 (-)NCBIGRCr8
mRatBN7.2251,411,413 - 51,505,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,411,413 - 51,504,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx258,530,027 - 58,623,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,588,743 - 56,682,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,516,043 - 51,616,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
Nnt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,685,516 - 18,778,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,685,511 - 18,778,024 (-)NCBIChiLan1.0ChiLan1.0
NNT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2466,619,709 - 66,724,900 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1564,774,508 - 64,878,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0566,662,249 - 66,772,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,719,257 - 71,823,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,719,257 - 71,823,242 (-)Ensemblpanpan1.1panPan2
NNT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1466,348,222 - 66,437,889 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl466,349,318 - 66,442,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha466,108,885 - 66,203,350 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0466,840,719 - 66,935,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,840,739 - 66,934,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,598,942 - 66,693,215 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,729,845 - 66,824,004 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,265,089 - 67,359,365 (-)NCBIUU_Cfam_GSD_1.0
Nnt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,662,542 - 209,755,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,598,481 - 18,691,859 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,599,037 - 18,692,097 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NNT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,157,318 - 28,250,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,157,192 - 28,248,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21629,706,049 - 29,756,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nnt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475911,521,778 - 11,628,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475911,520,793 - 11,628,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000014843   ⟹   ENSCSAP00000012804
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl442,384,435 - 42,477,002 (+)Ensembl
RefSeq Acc Id: XM_007961524   ⟹   XP_007959715
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,378,586 - 42,476,247 (+)NCBI
Vero_WHO_p1.0NW_02366607132,851,698 - 32,963,503 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961525   ⟹   XP_007959716
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,379,584 - 42,476,180 (+)NCBI
Vero_WHO_p1.0NW_02366607132,852,063 - 32,963,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961526   ⟹   XP_007959717
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,377,979 - 42,476,247 (+)NCBI
Vero_WHO_p1.0NW_02366607132,851,165 - 32,963,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961528   ⟹   XP_007959719
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,377,979 - 42,476,247 (+)NCBI
Vero_WHO_p1.0NW_02366607132,851,178 - 32,963,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961529   ⟹   XP_007959720
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,378,344 - 42,476,247 (+)NCBI
Vero_WHO_p1.0NW_02366607132,851,251 - 32,963,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961530   ⟹   XP_007959721
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1442,388,628 - 42,476,247 (+)NCBI
Vero_WHO_p1.0NW_02366607132,862,853 - 32,963,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990802   ⟹   XP_037846730
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607132,851,549 - 32,963,567 (+)NCBI
RefSeq Acc Id: XP_007959719   ⟸   XM_007961528
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959717   ⟸   XM_007961526
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959720   ⟸   XM_007961529
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959715   ⟸   XM_007961524
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959716   ⟸   XM_007961525
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959721   ⟸   XM_007961530
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000012804   ⟸   ENSCSAT00000014843
RefSeq Acc Id: XP_037846730   ⟸   XM_037990802
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW15 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014843.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro Ala_DH/PNT_CS2 UniProtKB/TrEMBL
  AlaDH/PNT_CS1 UniProtKB/TrEMBL
  AlaDH/PNT_N UniProtKB/TrEMBL
  AlaDH/PNT_NAD(H)-bd UniProtKB/TrEMBL
  DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NADP_transhyd_a UniProtKB/TrEMBL
  NADP_transhyd_a_C UniProtKB/TrEMBL
  PNTB-like UniProtKB/TrEMBL
KEGG Report csab:103215223 UniProtKB/TrEMBL
NCBI Gene NNT ENTREZGENE
PANTHER NAD(P) TRANSHYDROGENASE UniProtKB/TrEMBL
  NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
  PNTB UniProtKB/TrEMBL
  PNTB_4TM UniProtKB/TrEMBL
PROSITE ALADH_PNT_1 UniProtKB/TrEMBL
  ALADH_PNT_2 UniProtKB/TrEMBL
SMART AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52467 UniProtKB/TrEMBL
UniProt A0A0D9RW15 ENTREZGENE, UniProtKB/TrEMBL