ISG20L2 (interferon stimulated exonuclease gene 20 like 2) - Rat Genome Database

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Gene: ISG20L2 (interferon stimulated exonuclease gene 20 like 2) Chlorocebus sabaeus
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Symbol: ISG20L2
Name: interferon stimulated exonuclease gene 20 like 2
RGD ID: 18789091
Description: ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); nucleic acid binding (inferred); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interferon-stimulated 20 kDa exonuclease-like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,136,174 - 7,141,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,136,956 - 7,141,140 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,429,852 - 6,436,586 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ISG20L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,136,174 - 7,141,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,136,956 - 7,141,140 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,429,852 - 6,436,586 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ISG20L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,721,891 - 156,728,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,721,891 - 156,728,766 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,691,683 - 156,698,558 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,959,037 - 154,964,329 (-)NCBINCBI36Build 36hg18NCBI36
Celera1129,763,215 - 129,768,507 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,049,908 - 128,055,200 (-)NCBIHuRef
CHM1_11158,088,635 - 158,093,927 (-)NCBICHM1_1
T2T-CHM13v2.01155,858,294 - 155,865,169 (-)NCBIT2T-CHM13v2.0
Isg20l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,837,602 - 87,847,994 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,837,621 - 87,847,993 (+)EnsemblGRCm39 Ensembl
GRCm38387,930,314 - 87,940,686 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,930,314 - 87,940,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37387,734,236 - 87,744,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,016,241 - 88,026,613 (+)NCBIMGSCv36mm8
Celera387,967,709 - 87,978,083 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
Isg20l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,694,638 - 175,704,125 (+)NCBIGRCr8
mRatBN7.22173,396,780 - 173,407,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,396,780 - 173,406,614 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,541,553 - 180,551,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,563,909 - 178,573,394 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,164,008 - 173,173,491 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,302,192 - 187,311,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,302,192 - 187,311,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,705,209 - 206,714,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,009,276 - 180,018,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,959,381 - 179,968,867 (+)NCBI
Celera2167,345,979 - 167,355,464 (+)NCBICelera
Cytogenetic Map2q34NCBI
Isg20l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,795,936 - 2,804,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,797,370 - 2,804,142 (-)NCBIChiLan1.0ChiLan1.0
ISG20L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,115,966 - 93,123,273 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,850,452 - 92,857,763 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,064,860 - 132,071,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,887,702 - 135,893,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,887,702 - 135,892,908 (-)Ensemblpanpan1.1panPan2
ISG20L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,258,140 - 41,263,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,258,750 - 41,263,003 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,745,687 - 40,751,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,121,505 - 41,127,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,121,639 - 41,127,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,903,448 - 40,908,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,956,351 - 40,961,857 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,240,102 - 41,245,606 (+)NCBIUU_Cfam_GSD_1.0
Isg20l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,846,106 - 26,853,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,876,248 - 5,884,314 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,876,488 - 5,883,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISG20L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,366,241 - 93,372,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,366,188 - 93,372,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,938,053 - 101,943,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Isg20l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,874,331 - 1,885,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,878,939 - 1,885,743 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 4 36
Low 16 24
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000000194   ⟹   ENSCSAP00000015859
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl207,136,956 - 7,141,140 (+)Ensembl
RefSeq Acc Id: XM_007976727   ⟹   XP_007974918
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,136,205 - 7,141,404 (+)NCBI
Vero_WHO_p1.0NW_0236660386,430,188 - 6,436,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007976728   ⟹   XP_007974919
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,136,194 - 7,141,304 (+)NCBI
Vero_WHO_p1.0NW_0236660386,429,852 - 6,436,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007976729   ⟹   XP_007974920
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,136,194 - 7,141,304 (+)NCBI
Vero_WHO_p1.0NW_0236660386,429,852 - 6,436,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007976730   ⟹   XP_007974921
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,136,174 - 7,141,304 (+)NCBI
Vero_WHO_p1.0NW_0236660386,430,190 - 6,436,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037997746   ⟹   XP_037853674
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660386,430,180 - 6,436,586 (+)NCBI
RefSeq Acc Id: XM_037997748   ⟹   XP_037853676
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660386,430,179 - 6,436,586 (+)NCBI
RefSeq Acc Id: XP_007974921   ⟸   XM_007976730
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974920   ⟸   XM_007976729
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974919   ⟸   XM_007976728
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974918   ⟸   XM_007976727
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015859   ⟸   ENSCSAT00000000194
RefSeq Acc Id: XP_037853676   ⟸   XM_037997748
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037853674   ⟸   XM_037997746
- UniProtKB: A0A0D9S4S0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000194.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  ISG20_DEDDh UniProtKB/TrEMBL
  REXO1/3/4-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
KEGG Report csab:103223828 UniProtKB/TrEMBL
NCBI Gene ISG20L2 ENTREZGENE
PANTHER PTHR12801:SF78 UniProtKB/TrEMBL
  RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED UniProtKB/TrEMBL
Pfam RNase_T UniProtKB/TrEMBL
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
UniProt A0A0D9S4S0 ENTREZGENE, UniProtKB/TrEMBL