HRG (histidine rich glycoprotein)

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Gene: HRG (histidine rich glycoprotein) Chlorocebus sabaeus

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Symbol:

HRG

Name:

histidine rich glycoprotein

RGD ID:

18784527

Description:

ENCODES a protein that exhibits heme binding (ortholog); heparan sulfate proteoglycan binding (ortholog); immunoglobulin binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to fungus (ortholog); fibrinolysis (ortholog); ASSOCIATED WITH 3MC syndrome 1 (ortholog); Breast Neoplasms (ortholog); Carotid Atherosclerosis (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histidine-rich glycoprotein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	2,753,819 - 2,766,946 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	2,753,810 - 2,766,478 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	11,490,597 - 11,503,244 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3MC syndrome 1 (ISO)

Breast Neoplasms (ISO)

Carotid Atherosclerosis (ISO)

hemorrhagic disease (ISO)

pancreatic adenocarcinoma (ISO)

thrombophilia due to HRG deficiency (ISO)

thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

blood coagulation (IEA)

defense response to fungus (ISO)

fibrinolysis (IEA,ISO)

heme transport (IEA)

negative regulation of angiogenesis (ISO)

negative regulation of blood vessel endothelial cell migration (ISO)

negative regulation of cell adhesion (ISO)

negative regulation of cell adhesion mediated by integrin (ISO)

negative regulation of cell growth (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of endopeptidase activity (IEA)

negative regulation of endothelial cell chemotaxis (ISO)

negative regulation of fibrinolysis (IEA,ISO)

negative regulation of lamellipodium assembly (ISO)

negative regulation of vascular endothelial growth factor signaling pathway (ISO)

platelet activation (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of blood vessel remodeling (ISO)

positive regulation of focal adhesion assembly (ISO)

positive regulation of immune response to tumor cell (ISO)

regulation of actin cytoskeleton organization (ISO)

regulation of blood coagulation (ISO)

regulation of gene expression (ISO)

regulation of peptidyl-tyrosine phosphorylation (ISO)

regulation of platelet activation (IEA)

regulation of protein-containing complex assembly (ISO)

Cellular Component

blood microparticle (IEA)

cell surface (ISO)

endolysosome (IEA)

extracellular region (IEA)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

heme binding (ISO)

heparan sulfate proteoglycan binding (ISO)

heparin binding (IEA)

immunoglobulin binding (ISO)

metal ion binding (ISO)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA)

signaling receptor binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HRG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	2,753,819 - 2,766,946 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	2,753,810 - 2,766,478 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	11,490,597 - 11,503,244 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HRG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	186,666,014 - 186,678,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	186,660,216 - 186,678,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	186,383,803 - 186,396,023 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	187,866,492 - 187,878,717 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	187,866,499 - 187,878,724	NCBI
Celera	3	184,820,230 - 184,832,456 (+)	NCBI		Celera
Cytogenetic Map	3	q27.3	NCBI
HuRef	3	183,793,470 - 183,805,692 (+)	NCBI		HuRef
CHM1_1	3	186,347,752 - 186,359,974 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	189,487,766 - 189,499,996 (+)	NCBI		T2T-CHM13v2.0

Hrg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	22,769,822 - 22,780,409 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	22,769,822 - 22,780,406 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	22,951,072 - 22,961,659 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	22,951,072 - 22,961,656 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	22,951,145 - 22,961,732 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	22,866,448 - 22,876,980 (+)	NCBI		MGSCv36	mm8
Celera	16	23,511,005 - 23,521,593 (+)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	13.79	NCBI

Hrg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	91,559,087 - 91,573,982 (-)	NCBI		GRCr8
mRatBN7.2	11	78,054,488 - 78,069,402 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	78,054,498 - 78,069,389 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	86,804,961 - 86,819,853 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	79,463,216 - 79,478,058 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	78,519,273 - 78,534,165 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	81,621,274 - 81,639,938 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	84,718,226 - 84,736,651 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	80,248,578 - 80,264,179 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	80,306,169 - 80,321,768 (-)	NCBI
Celera	11	76,927,058 - 76,941,902 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Hrg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	21,019,212 - 21,032,976 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	21,020,938 - 21,033,022 (-)	NCBI	ChiLan1.0	ChiLan1.0

HRG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	184,541,834 - 184,554,072 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	184,546,549 - 184,558,787 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	183,701,069 - 183,712,365 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	192,168,299 - 192,180,539 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	192,168,299 - 192,180,539 (+)	Ensembl	panpan1.1		panPan2

HRG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	19,276,487 - 19,286,540 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	19,276,549 - 19,286,537 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	23,361,891 - 23,371,917 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	19,187,471 - 19,197,522 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	19,187,509 - 19,197,783 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	19,219,778 - 19,229,696 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	19,219,621 - 19,229,772 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	19,448,102 - 19,458,128 (+)	NCBI		UU_Cfam_GSD_1.0

Hrg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	117,193,744 - 117,204,015 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	3,285,986 - 3,295,876 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936578	3,285,986 - 3,295,876 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HRG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	124,505,312 - 124,516,705 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	124,505,305 - 124,516,387 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	133,895,233 - 133,906,338 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hrg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	70,070,302 - 70,086,256 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007971818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000012220 ⟹ ENSCSAP00000010266

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	15	2,753,810 - 2,766,478 (-)	Ensembl

RefSeq Acc Id:

XM_007971818 ⟹ XP_007970009

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	2,753,819 - 2,766,946 (-)	NCBI
Vero_WHO_p1.0	NW_023666063	11,490,597 - 11,503,244 (-)	NCBI

Sequence:

show sequence

CCAGGTTGAAAATTCAGATCTGACTTCAAAATGACAGCCTCTTCATTATTCTATTTCACCTGAA
GTCACTTCCTTTTATAATGGTACCTGTTTAACATGTTCCCTCCCTTAGATAATGCAGCTGCCTT
CTACTGAGGAGTTTTAGTGCCTTGATCCATCAATCCACTGACTGATGATGGAGATTTCCAGCCG
AGACAGACAGGCAGATAGAGGAAAATTACCCCTAGCCCCACCCCCTACACCAGCATAGGCACTG
CGTATGTTCCAAGACATACTTTAGATCTGCTATCTACTAGAAAAATCCAGATTTGTGCAGATCA
CAGTTCCACCCACTCAGCAGCATTTCTCAACTTTCTGTCCCCAAGACCCACTAATCATTTACAG
CTTGTTGATGGTTATTTGAACCCAGGGTCAAGGTGAACACCCCCAGTTACACAACAAAAAGGTA
TCAAGGTTTTGTTTAATCAATTGCATGTGTTTCAGAAAGTCTGTATAAAATTCTCTGCAGTGGC
AGATCATAGCAAGGGATGGTTTAACAAAATGAAGGCGCTCATTGCAGCACTGCTTTTGATCACA
CTGCAGGATTCGTGTGCTGTGAGTCCCACCGACTGCAGCGCTATTGAGCCGGAGGCTGAGAAAG
CTCTTGACCTGATCAATAAAAGGCGATGGGATGGCTACCTTTTCCAATTGCTGCGGGTTGCTGA
TGCCCACTTGGACAGAGTGGAAAATGCAACTGTATATTACTTAGCCTTAGATGTGCAAGAATCT
GACTGCTCGGTCCTATCCAGGAAACACTGGAATGAGTGTGAGCCACCTGATTCCAGACGTCCAT
CTGAAATAGTGATCGGACAATGTAAGGTAATAGCTACAGGACATTCCCATGAATCTCAGGATCT
CAGAGTGATTGACTTTAACTGCACCACAAGTTCTGTCTCTTCAGCACTGGCCAATACCAAAGAT
AGTCCCAACCTGTTAGATTTCTTTGAGGATACTGAGAGCTACAGAAAGCAAGCCGACAAAGCCC
TTGAGAAGTACAAAGAGGAGAATGATGACTTTGCCTCTTTCAGAGTGGACCGAATTGAGAGAGT
TGCAAAAGTGAGAAGAGGGGAAGGAACCAGTTACTTCATGGACTTCTCTGTGCGGAACTGCTCC
AGACACTATTTCCCCAGACACCCCAATGTCTTTGGATTCTGCAAAGCAGATTTGTTCTATGATG
TAGAAGCCTTGGACTTGGAAAGCCCGAAAGACCTTGTCATAAACTGCGAAGTCTTCGACCCTCA
GGAACATGGGAACATCAAGGGTGTACCGCCTCATTTGAGACATCCCTTCCACTGGGGTGGGCAT
GAGCACTCTTCTACCACCACCAAGTCTCCACTCAAGCCCCATGGATCCAGAGATCATCGTCATC
CCCACGAGCCACACAAACATGGACGACCACCTCCTCCAGATGAAAGAGATCACTTACATGGACC
CCCACTTCCACAAGGCACTCCTCCACTATTGCCCATGTCCTGCTCAAGATGTCATCATGCCACT
TTTGGCACGAATGGGGCCCAAAGACATCCTCATAATAATAATTCCAGTGACCTCCATCCCCATA
AGCATCATTCCCATGAACACCATTCTCATGGACACCATCCCCATGCACACCATCCTCACGAACA
CGGTACCCATAGACAGCATCCCCATGGACACCATCCCCATGGGCATCATCCGCATGGGCACCAT
CCGCATGGACACCATCCCCACTGCCATGATTTCCAAGACTATGGACCTTGTGACCCACCACCCC
ATAACCAATGTCACCATTGCCATGGCCACGGCCCACCACCTGGGCACTTAAGAAGACGAGGCCC
GGGTAAAGGACACCGTCCCTTCCATTGCAGACAACCTGGATCTGTGTACCGACTCCCTTCTCTA
AGGAAAGGTGAGGTGCTGCCACTTCCTGAAGCCAATTTTCCCAGCTTCCCATTGCCGCACCACA
AACACCCTCTAAAGCCAGACATTCAGCCCTTTCCTCAATCAGCCTCTGAATCATGTCCAGGGAA
GTTCAAGAGTGAGTTTTCACAAGTTTCCAATTTTTTCACACATTCACTTCCAAAATAAAATGTG
ATTCCTTTGAAGAGGAAAATGAATTATACATTGAATTAGAATCATAAATAAAATGACCAGTAAT
TTTGAAAATTACAGTTCTTTTCTACTTGCTTTCATACTGGAGATGCAGCAAAATGTGAATGGGA
AAAGAGATGGCCTGAGAAGAAAGATCAAATGGAAAGGAGAGGAAAGAACTCAGTGCTGCCAATT
AGTAGTTAATTCTGTCACTCACCACTACATCACCTGAGGCAAATCTATGCCACTCAGAATCTCC
TTCTTTCCTGGACTTAACTCTAATTCTAGAGTCTCTCTTACTGCTTGGGCTATACCTGGGCATA
CCAATAAAGTATGGTATTGAAACTAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007970009	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010266.1

RefSeq Acc Id:	XP_007970009 ⟸ XM_007971818
- UniProtKB:	A0A0D9RNS7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000010266 ⟸ ENSCSAT00000012220

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014125	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012220.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.10	UniProtKB/TrEMBL
InterPro	Cystatin_dom	UniProtKB/TrEMBL
	Cystatin_sf	UniProtKB/TrEMBL
	Kininogen_Fetuin_HRG	UniProtKB/TrEMBL
KEGG Report	csab:103221090	UniProtKB/TrEMBL
NCBI Gene	HRG	ENTREZGENE
PANTHER	FETUIN	UniProtKB/TrEMBL
	HISTIDINE-RICH GLYCOPROTEIN	UniProtKB/TrEMBL
Pfam	Cystatin	UniProtKB/TrEMBL
SMART	SM00043	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54403	UniProtKB/TrEMBL
UniProt	A0A0D9RNS7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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