FCHSD2 (FCH and double SH3 domains 2) - Rat Genome Database

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Gene: FCHSD2 (FCH and double SH3 domains 2) Chlorocebus sabaeus
Analyze
Symbol: FCHSD2
Name: FCH and double SH3 domains 2
RGD ID: 18784493
Description: ENCODES a protein that exhibits phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); membrane organization (ortholog); positive regulation of actin filament polymerization (ortholog); ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN clathrin-coated pit (ortholog); plasma membrane (ortholog); stereocilium shaft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-BAR and double SH3 domains protein 2; FCH and double SH3 domains protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,073,563 - 64,383,695 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,075,109 - 64,383,589 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,501,289 - 61,808,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FCHSD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,073,563 - 64,383,695 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,075,109 - 64,383,589 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,501,289 - 61,808,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FCHSD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,836,745 - 73,142,318 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,836,745 - 73,142,318 (-)EnsemblGRCh38hg38GRCh38
GRCh371172,547,790 - 72,853,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,225,439 - 72,530,739 (-)NCBINCBI36Build 36hg18NCBI36
Build 341172,225,438 - 72,530,739NCBI
Celera1169,852,315 - 70,157,746 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,842,883 - 69,148,230 (-)NCBIHuRef
CHM1_11172,431,560 - 72,736,921 (-)NCBICHM1_1
T2T-CHM13v2.01172,764,983 - 73,070,534 (-)NCBIT2T-CHM13v2.0
Fchsd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,757,836 - 100,933,613 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,742,070 - 100,933,612 (+)EnsemblGRCm39 Ensembl
GRCm387101,108,499 - 101,284,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,092,863 - 101,284,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,257,289 - 108,432,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,982,900 - 101,158,492 (+)NCBIMGSCv36mm8
Celera7101,462,084 - 101,640,492 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.5NCBI
Fchsd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,775,916 - 165,097,391 (+)NCBIGRCr8
mRatBN7.21155,444,471 - 155,685,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,444,460 - 155,685,539 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,444,296 - 163,670,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,624,387 - 170,850,278 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,508,019 - 163,734,459 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,140,025 - 166,395,915 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,125,474 - 166,395,915 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,337,554 - 172,460,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01172,505,865 - 172,585,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,548,830 - 158,782,422 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,626,026 - 158,861,250 (+)NCBI
Celera1153,543,242 - 153,768,063 (+)NCBICelera
Cytogenetic Map1q32NCBI
Fchsd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,343,832 - 18,597,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,343,832 - 18,597,675 (+)NCBIChiLan1.0ChiLan1.0
FCHSD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,784,216 - 74,087,870 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,827,644 - 75,131,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,915,796 - 68,219,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11171,138,187 - 71,440,818 (-)NCBIpanpan1.1PanPan1.1panPan2
FCHSD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,082,864 - 25,399,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,072,161 - 25,397,717 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,836,372 - 25,169,938 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,289,701 - 25,607,172 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,289,677 - 25,607,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,072,096 - 25,399,594 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,274,840 - 25,602,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,188,533 - 25,516,358 (+)NCBIUU_Cfam_GSD_1.0
Fchsd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,489,529 - 60,744,762 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,086,282 - 2,344,708 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,089,069 - 2,344,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCHSD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,366,523 - 7,608,469 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,366,516 - 7,619,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,128,484 - 8,362,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Fchsd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,819,178 - 4,135,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,819,124 - 4,134,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 6 36
Low 16 14 24
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002109   ⟹   ENSCSAP00000000438
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl164,075,109 - 64,383,589 (-)Ensembl
RefSeq Acc Id: XM_008020054   ⟹   XP_008018245
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1164,073,563 - 64,383,695 (-)NCBI
Vero_WHO_p1.0NW_02366604361,501,289 - 61,808,431 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020055   ⟹   XP_008018246
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1164,073,563 - 64,382,722 (-)NCBI
Vero_WHO_p1.0NW_02366604361,502,648 - 61,808,431 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020056   ⟹   XP_008018247
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1164,073,563 - 64,383,691 (-)NCBI
Vero_WHO_p1.0NW_02366604361,501,291 - 61,808,431 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038005503   ⟹   XP_037861431
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604361,503,856 - 61,808,431 (+)NCBI
RefSeq Acc Id: XM_038005504   ⟹   XP_037861432
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604361,503,868 - 61,808,431 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008018245   ⟸   XM_008020054
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008018247   ⟸   XM_008020056
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QVP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008018246   ⟸   XM_008020055
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000000438   ⟸   ENSCSAT00000002109
RefSeq Acc Id: XP_037861431   ⟸   XM_038005503
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037861432   ⟸   XM_038005504
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004080 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002109.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  FCHSD2 UniProtKB/TrEMBL
  FCHSD2_SH3_2 UniProtKB/TrEMBL
  FCHSD_SH3_1 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene FCHSD2 ENTREZGENE
PANTHER FCH AND DOUBLE SH3 DOMAINS PROTEIN UniProtKB/TrEMBL
  PTHR15735:SF11 UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9QVP9 ENTREZGENE, UniProtKB/TrEMBL