TMPRSS2 (transmembrane serine protease 2) - Rat Genome Database

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Gene: TMPRSS2 (transmembrane serine protease 2) Chlorocebus sabaeus
Analyze
Symbol: TMPRSS2
Name: transmembrane serine protease 2
RGD ID: 18783712
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN positive regulation of viral entry into host cell (inferred); protein autoprocessing (inferred); proteolysis (inferred); ASSOCIATED WITH prostate adenocarcinoma (ortholog); prostatic hypertrophy (ortholog); severe acute respiratory syndrome (ortholog); FOUND IN membrane (inferred); nucleoplasm (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane protease serine 2; transmembrane protease, serine 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,372,881 - 85,413,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,372,117 - 85,412,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,228,416 - 13,267,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:32574196  


Genomics

Comparative Map Data
TMPRSS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,372,881 - 85,413,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,372,117 - 85,412,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,228,416 - 13,267,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TMPRSS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,529,791 - 41,531,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,464,300 - 41,531,116 (-)EnsemblGRCh38hg38GRCh38
GRCh372142,836,232 - 42,880,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,758,351 - 41,801,948 (-)NCBINCBI36Build 36hg18NCBI36
Build 342141,758,350 - 41,801,948NCBI
Celera2128,034,659 - 28,078,450 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,305,352 - 28,349,365 (-)NCBIHuRef
CHM1_12142,397,265 - 42,440,908 (-)NCBICHM1_1
Tmprss2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,365,882 - 97,460,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,365,882 - 97,412,395 (-)EnsemblGRCm39 Ensembl
GRCm381697,564,682 - 97,659,541 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,564,682 - 97,611,195 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,786,289 - 97,832,802 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,719,598 - 97,766,111 (-)NCBIMGSCv36mm8
Celera1698,625,511 - 98,672,561 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.53NCBI
Tmprss2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,403,707 - 50,443,224 (-)NCBIGRCr8
mRatBN7.21136,934,306 - 36,973,779 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,934,306 - 36,973,715 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,634,788 - 45,674,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,306,168 - 38,345,554 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,466,096 - 37,505,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01138,063,914 - 38,103,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,063,915 - 38,103,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,574,415 - 41,613,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,577,051 - 37,617,258 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,634,640 - 37,674,847 (-)NCBI
Celera1136,819,034 - 36,858,331 (-)NCBICelera
Cytogenetic Map11q12NCBI
Tmprss2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540740,957,122 - 40,976,644 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540740,958,562 - 40,985,415 (-)NCBIChiLan1.0ChiLan1.0
TMPRSS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,547,072 - 37,580,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,401,351 - 32,434,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02127,800,466 - 27,843,395 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,128,358 - 41,170,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,131,515 - 41,161,088 (-)Ensemblpanpan1.1panPan2
Tmprss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,245,118 - 35,277,589 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,199,835 - 2,222,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,199,877 - 2,222,174 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Tmprss2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,573,095 - 28,595,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,565,515 - 28,593,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 22 15 20
Below cutoff 14 5 22

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006283   ⟹   ENSCSAP00000004490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl285,372,117 - 85,412,926 (-)Ensembl
RefSeq Acc Id: XM_037985428   ⟹   XP_037841356
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605413,228,416 - 13,267,943 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037841356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004490.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000004490   ⟸   ENSCSAT00000006283
RefSeq Acc Id: XP_037841356   ⟸   XM_037985428


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006283.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene TMPRSS2 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE SERINE PROTEASE 2 UniProtKB/TrEMBL
Pfam SRCR_2 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
  SM00202 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF56487 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A0D9R7A1_CHLSB UniProtKB/TrEMBL