TOP3B (DNA topoisomerase III beta)

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Gene: TOP3B (DNA topoisomerase III beta) Chlorocebus sabaeus

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Symbol:

TOP3B

Name:

DNA topoisomerase III beta

RGD ID:

18780009

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN chromosome segregation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 3-beta-1; topoisomerase (DNA) III beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,137,823 - 4,163,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,137,862 - 4,166,436 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,836,805 - 2,865,520 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

DiGeorge syndrome (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome segregation (IEA,ISO)

DNA recombination (IEA)

DNA repair (IEA)

DNA topological change (IEA)

Cellular Component

condensed chromosome (IEA)

DNA topoisomerase III-beta-TDRD3 complex (IEA)

nucleus (IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IEA)

protein binding (ISO)

RNA topoisomerase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,137,823 - 4,163,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,137,862 - 4,166,436 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,836,805 - 2,865,520 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TOP3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,957,025 - 21,982,787 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,957,025 - 21,982,813 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,311,397 - 22,337,184 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,641,403 - 20,667,147 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,635,957 - 20,661,701	NCBI
Celera	22	6,128,944 - 6,154,663 (-)	NCBI		Celera
Cytogenetic Map	22	q11.22	NCBI
HuRef	22	5,268,479 - 5,294,196 (-)	NCBI		HuRef
CHM1_1	22	22,311,501 - 22,337,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,370,556 - 22,396,320 (-)	NCBI		T2T-CHM13v2.0

Top3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,688,587 - 16,710,850 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,688,600 - 16,710,854 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	16,870,722 - 16,892,986 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	16,870,736 - 16,892,990 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	16,870,984 - 16,893,079 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	16,784,454 - 16,806,549 (+)	NCBI		MGSCv36	mm8
Celera	16	17,442,801 - 17,464,977 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.46	NCBI

Top3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,601,223 - 97,629,678 (-)	NCBI		GRCr8
mRatBN7.2	11	84,097,018 - 84,125,474 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	84,097,026 - 84,125,392 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,821,137 - 92,849,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,482,270 - 85,510,510 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,535,862 - 84,564,108 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,346,305 - 88,374,896 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,346,313 - 88,374,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,401,389 - 91,429,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	86,116,936 - 86,145,314 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,157,538 - 86,185,850 (-)	NCBI
Celera	11	82,851,647 - 82,880,025 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Top3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,200,453 - 17,225,335 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,201,079 - 17,223,824 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,498,751 - 31,524,557 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	34,047,630 - 34,073,423 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	4,076,295 - 4,102,086 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,557,248 - 20,583,307 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,557,248 - 20,583,464 (-)	Ensembl	panpan1.1		panPan2

TOP3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	31,198,371 - 31,223,133 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	31,198,382 - 31,215,134 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	31,154,388 - 31,178,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,604,302 - 32,628,806 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,604,310 - 32,628,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,652,585 - 30,677,122 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,276,606 - 30,301,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,367,160 - 31,391,836 (-)	NCBI		UU_Cfam_GSD_1.0

Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,971,807 - 140,997,296 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,756,791 - 1,785,953 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,756,829 - 1,782,063 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,020,509 - 50,037,856 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,020,412 - 50,037,854 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,462,935 - 53,480,381 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Top3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,446,412 - 1,473,600 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,450,236 - 1,473,467 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007974906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007974907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007974908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007974909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037994793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037994794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_493635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011826 ⟹ ENSCSAP00000009886

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	19	4,137,862 - 4,166,436 (+)	Ensembl

RefSeq Acc Id:

XM_007974906 ⟹ XP_007973097

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	19	4,137,823 - 4,163,860 (+)	NCBI
Vero_WHO_p1.0	NW_023666085	2,839,441 - 2,865,520 (-)	NCBI

Sequence:

show sequence

CTGGCACACCGGACGCGGGGACGCCAGAAGCGGCTGGACCCGGAAGTAGGGGTTGCCGGTGGCC
GCCCCGGGAGCAAGGACCGGAGCAGGATGCGAGGTGTAGCTGCAGGGGTCAGCATTGATAATAG
TGCTTTGCTGCAGAAGAGTGGAGTCTAAACTTTTTCACTGCCAGTGCCCCGAAACTGGAGCGTA
AAGGGCTGAGACAAGATGAAGACTGTGCTCATGGTTGCCGAAAAGCCGTCCTTGGCACAGTCAA
TTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACATAAAGGGCTGAATGGGGCCTGTTCAGT
CCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCTGTGGT
CATGTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAAGTGGACCCCGCAGAAC
TGTTCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGAACATGGTGAAGTTCCT
GCAGGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTGTGACAAGGAGGGGGAG
AACATCTGCTTTGAGGTTCTTGATGCTGTTCTGCCCGTCATGAACAAGGCCTATGGTGGTGAGA
AGACCGTGTTCCGGGCCAGGTTTAGCTCCATCACAGACACAGACATCTGTAATGCCATGGCCTG
CCTGGGCGAGCCTGACCACAACGAGGCGCTCTCAGTGGATGCTCGCCAGGAACTGGACCTGCGA
ATCGGCTGTGCATTCACCAGGTTTCAGACTAAATATTTCCAGGGGAAATACGGTGATTTAGACA
GCTCTCTCATCTCCTTTGGGCCGTGTCAGACTCCAACCCTGGGATTCTGCGTGGAGAGACATGA
TAAAATCCAGTCCTTCAAACCAGAGACCTACTGGGTGCTGCAGGCCAAGGTTAACACTGACAAA
GACAGATCTCTCCTTTTGGACTGGGACCGAGTAAGAGTGTTTGACCGGGAGATCGCACAGATGT
TTTTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAAAAGGC
CAAGCAGAGGCCCCTGGCCCTGAACACCGTGGAGATGCTGCGTGTGGCCAGCTCTTCTCTGGGC
ATGGGGCCGCAGCACGCCATGCAGACAGCCGAGCGGCTCTACACACAAGGCTACATCAGCTACC
CACGGACAGAGACCACCCACTACCCTGAGAACTTTGACCTGAAGGGCTCTCTGCGGCAGCAAGC
CAACCACCCCTACTGGGCCGACACGGTGAAGCGGTTGTTAGCAGAAGGTATCAACCGCCCGCGG
AAAGGCCACGACGCTGGCGACCATCCCCCCATCACCCCCATGAAGTCTGCCACAGAGGCCGAAT
TAGGGGGTGACGCATGGCGGCTCTATGAGTACATCACCAGACACTTCATTGCCACGGTCAGCCA
TGACTGCAAGTACCTGCAGAGCACCATCTCCTTCAGGATCGGGCCCGAGCTCTTCACCTGCTCC
GGGAAGACCGTCCTCTCCCCAGGCTTCACGGAGATCATGCCCTGGCAGAGCGTGCCCTTGGAGG
AGAACCTGCCCACTTGCCAGCGGGGCGACACCTTCCCTGTGGGTGAGGTCAAGATGCTGGAGAA
GCAGACGAGCCCGCCCGACTACCTGACAGAGGCTGAGCTCATCACGCTCATGGAGAAGCATGGC
ATCGGCACAGATGCCAGCATCCCTGTGCATATCAACAACATCTGCCAGCGCAACTACGTCACCG
TGGAGAGCGGACGCCGGCTCAAGCCCACCAACCTCGGCATCGTCCTGGTGCACGGCTACTACAA
GATTGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAGAAGCAGCTGAACCTGATC
GCCCAGGGCAAGGCCGACTACCGCCAGGTCCTGGGCCACACCCTGGACGTGTTCAAGAGGAAGT
TCCACTACTTTGTCGACTCCATTGCCGGCATGGATGAGTTAATGGAGGTGTCTTTCTCGCCGCT
GGCGGCCACAGGCAAGCCCCTCTCACGCTGTGGGAAGTGCCACCGCTTCATGAAGTACATCCAG
GCCAAGCCAAGCCGCCTGCACTGCTCGCACTGCGATGAGACCTACACACTGCCCCAGAAGGGCA
CCATCAAGCTCTACAAGGAGCTCCGCTGCCCTCTGGATGACTTCGAGCTGGTCCTGTGGTCATC
AGGCTCTCGGGGCAAGAGCTACCCACTGTGCCCCTACTGCTACAACCACCCACCCTTCCGAGAC
ATGAAGAAAGGCATGGGCTGCAACGAGTGTACGCACCCCTCCTGCCAGCACTCGCTGAGCATGC
TGGGCATCGGCCAGTGCGTGGAATGCGAGAGCGGCGTGCTGGTCCTGGACCCCACCTCGGGCCC
CAAGTGGAAGGTGGCCTGCAACAAGTGCAGCGTGGTAGCGCACTGCTTCGAGAACGCCCACCGC
GTGCGGGTGTCCGCCGACACCTGCAGTGTCTGTGAGGCCGCCTTGCTTGACGTGGACTTCAACA
AGGCCAAGTCCCCACTCCCGGGCGACGAGACGCAGCACATGGGCTGTGTCTTCTGTGACCCCGT
CTTCCAGGAGCTGGTGGAGCTGAAGCATGCGGCCTCCTGCCACCCCATGCACCGCGGCGGGCCA
GGGAGAAGGCAGGGTCGAGGGCGGGGCCGGGCCAGGAGGCCCCCTGGGAAGCCCAACCCCAGAC
GGCCCAAGGACAAGATGTCAGCCCTGGCCGCCTACTTCGTATGATGGCCCTGTCCTCCCTCACC
CAGGCTACAGTGCCATGCAGACACTTCATGGCACTTCAAACTATTAAAATGCATTTTATCTTCT
CCAGA

hide sequence

RefSeq Acc Id:

XM_007974907 ⟹ XP_007973098

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	19	4,137,854 - 4,163,860 (+)	NCBI
Vero_WHO_p1.0	NW_023666085	2,839,447 - 2,865,463 (-)	NCBI

Sequence:

show sequence

GGCTGGACCCGGAAGTAGGGGTTGCCGGTGGCCGCCCCGGGAGCAAGGACCGGAGCAGGATGCG
AGGTGTAGCTGCAGGTGAGTCCACCTGTAGGTGGAAGAGCCAGTCCAGAGAGGAGGGCCAGGCA
TCCACCTGGCCTGACCCATCACTGGAGATCCCCAGGTCCCGGCATCTTCCTAGCGTGGATTTAG
GAATCAAATGGACCTAAGGAGCCAGATTCCCAGGATCATCTCAGCCACTTCAGTTGACCTGGGG
TCAGCATTGATAATAGTGCTTTGCTGCAGAAGAGTGGAGTCTAAACTTTTTCACTGCCAGTGCC
CCGAAACTGGAGCGTAAAGGGCTGAGACAAGATGAAGACTGTGCTCATGGTTGCCGAAAAGCCG
TCCTTGGCACAGTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACATAAAGGGCTGA
ATGGGGCCTGTTCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGAT
GACGTCTGTCTGTGGTCATGTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAA
GTGGACCCCGCAGAACTGTTCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGA
ACATGGTGAAGTTCCTGCAGGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTG
TGACAAGGAGGGGGAGAACATCTGCTTTGAGGTTCTTGATGCTGTTCTGCCCGTCATGAACAAG
GCCTATGGTGGTGAGAAGACCGTGTTCCGGGCCAGGTTTAGCTCCATCACAGACACAGACATCT
GTAATGCCATGGCCTGCCTGGGCGAGCCTGACCACAACGAGGCGCTCTCAGTGGATGCTCGCCA
GGAACTGGACCTGCGAATCGGCTGTGCATTCACCAGGTTTCAGACTAAATATTTCCAGGGGAAA
TACGGTGATTTAGACAGCTCTCTCATCTCCTTTGGGCCGTGTCAGACTCCAACCCTGGGATTCT
GCGTGGAGAGACATGATAAAATCCAGTCCTTCAAACCAGAGACCTACTGGGTGCTGCAGGCCAA
GGTTAACACTGACAAAGACAGATCTCTCCTTTTGGACTGGGACCGAGTAAGAGTGTTTGACCGG
GAGATCGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAA
GCAGGAAAGAAAAGGCCAAGCAGAGGCCCCTGGCCCTGAACACCGTGGAGATGCTGCGTGTGGC
CAGCTCTTCTCTGGGCATGGGGCCGCAGCACGCCATGCAGACAGCCGAGCGGCTCTACACACAA
GGCTACATCAGCTACCCACGGACAGAGACCACCCACTACCCTGAGAACTTTGACCTGAAGGGCT
CTCTGCGGCAGCAAGCCAACCACCCCTACTGGGCCGACACGGTGAAGCGGTTGTTAGCAGAAGG
TATCAACCGCCCGCGGAAAGGCCACGACGCTGGCGACCATCCCCCCATCACCCCCATGAAGTCT
GCCACAGAGGCCGAATTAGGGGGTGACGCATGGCGGCTCTATGAGTACATCACCAGACACTTCA
TTGCCACGGTCAGCCATGACTGCAAGTACCTGCAGAGCACCATCTCCTTCAGGATCGGGCCCGA
GCTCTTCACCTGCTCCGGGAAGACCGTCCTCTCCCCAGGCTTCACGGAGATCATGCCCTGGCAG
AGCGTGCCCTTGGAGGAGAACCTGCCCACTTGCCAGCGGGGCGACACCTTCCCTGTGGGTGAGG
TCAAGATGCTGGAGAAGCAGACGAGCCCGCCCGACTACCTGACAGAGGCTGAGCTCATCACGCT
CATGGAGAAGCATGGCATCGGCACAGATGCCAGCATCCCTGTGCATATCAACAACATCTGCCAG
CGCAACTACGTCACCGTGGAGAGCGGACGCCGGCTCAAGCCCACCAACCTCGGCATCGTCCTGG
TGCACGGCTACTACAAGATTGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAGAA
GCAGCTGAACCTGATCGCCCAGGGCAAGGCCGACTACCGCCAGGTCCTGGGCCACACCCTGGAC
GTGTTCAAGAGGAAGTTCCACTACTTTGTCGACTCCATTGCCGGCATGGATGAGTTAATGGAGG
TGTCTTTCTCGCCGCTGGCGGCCACAGGCAAGCCCCTCTCACGCTGTGGGAAGTGCCACCGCTT
CATGAAGTACATCCAGGCCAAGCCAAGCCGCCTGCACTGCTCGCACTGCGATGAGACCTACACA
CTGCCCCAGAAGGGCACCATCAAGCTCTACAAGGAGCTCCGCTGCCCTCTGGATGACTTCGAGC
TGGTCCTGTGGTCATCAGGCTCTCGGGGCAAGAGCTACCCACTGTGCCCCTACTGCTACAACCA
CCCACCCTTCCGAGACATGAAGAAAGGCATGGGCTGCAACGAGTGTACGCACCCCTCCTGCCAG
CACTCGCTGAGCATGCTGGGCATCGGCCAGTGCGTGGAATGCGAGAGCGGCGTGCTGGTCCTGG
ACCCCACCTCGGGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCAGCGTGGTAGCGCACTGCTT
CGAGAACGCCCACCGCGTGCGGGTGTCCGCCGACACCTGCAGTGTCTGTGAGGCCGCCTTGCTT
GACGTGGACTTCAACAAGGCCAAGTCCCCACTCCCGGGCGACGAGACGCAGCACATGGGCTGTG
TCTTCTGTGACCCCGTCTTCCAGGAGCTGGTGGAGCTGAAGCATGCGGCCTCCTGCCACCCCAT
GCACCGCGGCGGGCCAGGGAGAAGGCAGGGTCGAGGGCGGGGCCGGGCCAGGAGGCCCCCTGGG
AAGCCCAACCCCAGACGGCCCAAGGACAAGATGTCAGCCCTGGCCGCCTACTTCGTATGATGGC
CCTGTCCTCCCTCACCCAGGCTACAGTGCCATGCAGACACTTCATGGCACTTCAAACTATTAAA
ATGCATTTTATCTTCTCCAGA

hide sequence

RefSeq Acc Id:

XM_037994793 ⟹ XP_037850721

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666085	2,839,447 - 2,865,467 (-)	NCBI

RefSeq Acc Id:

XM_037994794 ⟹ XP_037850722

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666085	2,836,805 - 2,865,520 (-)	NCBI

RefSeq Acc Id:

XR_493635

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	19	4,137,826 - 4,163,372 (+)	NCBI
Vero_WHO_p1.0	NW_023666085	2,839,903 - 2,865,520 (-)	NCBI

Sequence:

show sequence

GCACACCGGACGCGGGGACGCCAGAAGCGGCTGGACCCGGAAGTAGGGGTTGCCGGTGGCCGCC
CCGGGAGCAAGGACCGGAGCAGGATGCGAGGTGTAGCTGCAGGGGTCAGCATTGATAATAGTGC
TTTGCTGCAGAAGAGTGGAGTCTAAACTTTTTCACTGCCAGTGCCCCGAAACTGGAGCGTAAAG
GGCTGAGACAAGATGAAGACTGTGCTCATGGTTGCCGAAAAGCCGTCCTTGGCACAGTCAATTG
CCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACATAAAGGGCTGAATGGGGCCTGTTCAGTCCA
CGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCTGTGGTCAT
GTGATGACCCTGGATTTCCTGGGAAAATACAACAAATGGGACAAAGTGGACCCCGCAGAACTGT
TCAGCCAAGCTCCCACGGAGAAGAAAGAAGCTAACCCCAAGCTGAACATGGTGAAGTTCCTGCA
GGTGGAGGGCAGAGGCTGCGACTACATCGTGCTGTGGCTGGACTGTGACAAGGAGGGGGAGAAC
ATCTGCTTTGAGGTTCTTGATGCTGTTCTGCCCGTCATGAACAAGGCCTATGGTGGTGAGAAGA
CCGTGTTCCGGGCCAGGTTTAGCTCCATCACAGACACAGACATCTGTAATGCCATGGCCTGCCT
GGGCGAGCCTGACCACAACGAGGCGCTCTCAGTGGATGCTCGCCAGGAACTGGACCTGCGAATC
GGCTGTGCATTCACCAGGTTTCAGACTAAATATTTCCAGGGGAAATACGGTGATTTAGACAGCT
CTCTCATCTCCTTTGGGCCGTGTCAGACTCCAACCCTGGGATTCTGCGTGGAGAGACATGATAA
AATCCAGTCCTTCAAACCAGAGACCTACTGGGTGCTGCAGGCCAAGGTTAACACTGACAAAGAC
AGATCTCTCCTTTTGGACTGGGACCGAGTAAGAGTGTTTGACCGGGAGATCGCACAGATGTTTT
TAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAAAAGGCCAA
GCAGAGGCCCCTGGCCCTGAACACCGTGGAGATGCTGCGTGTGGCCAGCTCTTCTCTGGGCATG
GGGCCGCAGCACGCCATGCAGACAGCCGAGCGGCTCTACACACAAGGCTACATCAGCTACCCAC
GGACAGAGACCACCCACTACCCTGAGAACTTTGACCTGAAGGGCTCTCTGCGGCAGCAAGCCAA
CCACCCCTACTGGGCCGACACGGTGAAGCGGTTGTTAGCAGAAGGTATCAACCGCCCGCGGAAA
GGCCACGACGCTGGCGACCATCCCCCCATCACCCCCATGAAGTCTGCCACAGAGGCCGAATTAG
GGGGTGACGCATGGCGGCTCTATGAGTACATCACCAGACACTTCATTGCCACGGTCAGCCATGA
CTGCAAGTACCTGCAGAGCACCATCTCCTTCAGGATCGGGCCCGAGCTCTTCACCTGCTCCGGG
AAGACCGTCCTCTCCCCAGGCTTCACGGAGATCATGCCCTGGCAGAGCGTGCCCTTGGAGGAGA
ACCTGCCCACTTGCCAGCGGGGCGACACCTTCCCTGTGGGTGAGGTCAAGATGCTGGAGAAGCA
GACGAGCCCGCCCGACTACCTGACAGAGGCTGAGCTCATCACGCTCATGGAGAAGCATGGCATC
GGCACAGATGCCAGCATCCCTGTGCATATCAACAACATCTGCCAGCGCAACTACGTCACCGTGG
AGAGCGGACGCCGGCTCAAGCCCACCAACCTCGGCATCGTCCTGGTGCACGGCTACTACAAGAT
TGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAGAAGCAGCTGAACCTGATCGCC
CAGGGCAAGGCCGACTACCGCCAGGTCCTGGGCCACACCCTGGACGTGTTCAAGAGGAAGTTCC
ACTACTTTGTCGACTCCATTGCCGGCATGGATGAGTTAATGGAGGTGTCTTTCTCGCCGCTGGC
GGCCACAGGCAAGCCCCTCTCACGCTGTGGGAAGTGCCACCGCTTCATGAAGTACATCCAGGCC
AAGCCAAGCCGCCTGCACTGCTCGCACTGCGATGAGACCTACACACTGCCCCAGAAGGGCACCA
TCAAGCTCTACAAGGAGCTCCGCTGCCCTCTGGATGACTTCGAGCTGGTCCTGTGGTCATCAGG
CTCTCGGGGCAAGAGCTACCCACTGTGCCCCTACTGCTACAACCACCCACCCTTCCGAGACATG
AAGAAAGGTGAGTGTGGCCGCTCCCTCCTGCCCATGGGTAACAGCAGTCTCTGTTCAGTGCCAA
CCCCTGCCTTGCACCAGGACGGACTCTGAGGGGACCCCTCACCCTGGCCTTTCCTGCACTCATT
GGCACTGAGACGAGAGACCCTGGATGTAGCTGGGGCACTGGTCAGGCCTCAGGCAGTGCTGCCA
CACCCTCTCTGTGTCAGAATTGAGCAGGCAACCCTAGTCCACCCTCAGGACCTGGGCACAGGTG
TGCAGTGCTCCCTCTGGAGCTGAGTGAGCAAAAGGATGGAACAGTCGGGGGACCCACCGGGTGA
GCAGACACCCCCAGTCAGCATCCACCACTGTCCTCCATCCTCATCCTCGTCCTCATTACTGGAG
GAGGGAGTGCATGTGTCCAGGCAGGCAGGACAGAGAAGCGCCAAGCCGGACCAGGAACCAGCAG
GAGTGAAGTGTCTGCCCACGTTCACCATGTGCTCTGCAGAGAGCCCCCTCAGGCCTCAGTCTGC
ACCCATGCTTCTGGGAAAGCATGGGCTGCAACGAGTGTACGCACCCCTCCTGCCAGCACTCGCT
GAGCATGCTGGGCATCGGCCAGTGCGTGGAATGCGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007973097	(Get FASTA)	NCBI Sequence Viewer
	XP_007973098	(Get FASTA)	NCBI Sequence Viewer
	XP_037850721	(Get FASTA)	NCBI Sequence Viewer
	XP_037850722	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009886.1

RefSeq Acc Id:	XP_007973097 ⟸ XM_007974906
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RMP7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007973098 ⟸ XM_007974907
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RMP7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009886 ⟸ ENSCSAT00000011826

RefSeq Acc Id:	XP_037850722 ⟸ XM_037994794
- Peptide Label:	isoform X3
- UniProtKB:	A0A0D9RMP7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037850721 ⟸ XM_037994793
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RMP7 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013729	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011826.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.290.10	UniProtKB/TrEMBL
	1.10.460.10	UniProtKB/TrEMBL
	2.70.20.10	UniProtKB/TrEMBL
	3.40.50.140	UniProtKB/TrEMBL
InterPro	Topo_IA	UniProtKB/TrEMBL
	Topo_IA_2	UniProtKB/TrEMBL
	Topo_IA_AS	UniProtKB/TrEMBL
	Topo_IA_cen	UniProtKB/TrEMBL
	Topo_IA_cen_sub1	UniProtKB/TrEMBL
	Topo_IA_cen_sub2	UniProtKB/TrEMBL
	Topo_IA_cen_sub3	UniProtKB/TrEMBL
	Topo_IA_core_domain	UniProtKB/TrEMBL
	Topo_IA_DNA-bd_dom	UniProtKB/TrEMBL
	TOPRIM_domain	UniProtKB/TrEMBL
	TOPRIM_TopoIII	UniProtKB/TrEMBL
KEGG Report	csab:103222938	UniProtKB/TrEMBL
NCBI Gene	TOP3B	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 3-BETA-1	UniProtKB/TrEMBL
	PTHR11390	UniProtKB/TrEMBL
Pfam	Topoisom_bac	UniProtKB/TrEMBL
	Toprim	UniProtKB/TrEMBL
PRINTS	PRTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_PROK	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
SMART	TOP1Ac	UniProtKB/TrEMBL
	TOP1Bc	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56712	UniProtKB/TrEMBL
UniProt	A0A0D9RMP7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar