PDGFA (platelet derived growth factor subunit A) - Rat Genome Database

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Gene: PDGFA (platelet derived growth factor subunit A) Chlorocebus sabaeus
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Symbol: PDGFA
Name: platelet derived growth factor subunit A
RGD ID: 18779210
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Animal Mammary Neoplasms (ortholog); Brain Injuries (ortholog); FOUND IN platelet-derived growth factor receptor-ligand complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet-derived growth factor subunit A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12821,044,549 - 21,068,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2821,047,219 - 21,069,827 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
angiogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
bone development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell projection assembly  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
digestive tract development  (IEA,ISO)
embryonic lung development  (IEA)
hair follicle development  (IEA,ISO)
inner ear development  (ISO)
lung alveolus development  (IEA,ISO)
male gonad development  (ISO)
negative chemotaxis  (IEA)
negative regulation of phosphatidylinositol biosynthetic process  (IEA)
negative regulation of platelet activation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein autophosphorylation  (ISO)
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling  (IEA,ISO)
regulation of DNA biosynthetic process  (ISO)
regulation of glomerular mesangial cell proliferation  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of smooth muscle cell migration  (IEA)
response to estradiol  (ISO)
response to hypoxia  (ISO)
response to retinoic acid  (ISO)
response to wounding  (IEA)
response to xenobiotic stimulus  (ISO)
skin development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12821,044,549 - 21,068,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2821,047,219 - 21,069,827 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PDGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387497,258 - 520,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7497,258 - 520,296 (-)EnsemblGRCh38hg38GRCh38
GRCh377536,895 - 560,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367503,421 - 526,007 (-)NCBINCBI36Build 36hg18NCBI36
Celera7505,832 - 559,337 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7455,023 - 477,393 (-)NCBIHuRef
CHM1_17535,640 - 589,379 (-)NCBICHM1_1
T2T-CHM13v2.07598,210 - 621,677 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27598,080 - 651,496 (-)NCBI
Pdgfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,961,761 - 138,986,336 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,961,769 - 138,983,125 (-)EnsemblGRCm39 Ensembl
GRCm385138,976,014 - 139,000,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,976,014 - 138,997,370 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,452,925 - 139,470,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,230,613 - 139,248,595 (-)NCBIMGSCv36mm8
Celera5136,032,139 - 136,049,986 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.65NCBI
Pdgfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,759,366 - 20,780,337 (+)NCBIGRCr8
mRatBN7.21215,645,549 - 15,667,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,645,541 - 15,666,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,456,582 - 16,477,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,080,317 - 17,101,307 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,102,867 - 16,123,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,734,141 - 17,756,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,734,133 - 17,755,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,727,672 - 19,749,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,151,045 - 16,172,412 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11216,180,972 - 16,202,334 (+)NCBI
Celera1217,398,134 - 17,419,591 (+)NCBICelera
Cytogenetic Map12q11NCBI
Pdgfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,326,891 - 8,346,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,328,400 - 8,346,755 (-)NCBIChiLan1.0ChiLan1.0
PDGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,432,364 - 5,455,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1753,757,065 - 53,780,304 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07648,722 - 672,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17872,204 - 888,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PDGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,271,082 - 16,293,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,270,104 - 16,292,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,743,941 - 17,762,483 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,400,056 - 16,421,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,400,113 - 16,420,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,204,088 - 16,222,628 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,130,433 - 16,148,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,420,378 - 16,438,910 (+)NCBIUU_Cfam_GSD_1.0
Pdgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,181,428 - 144,201,439 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936754808,213 - 828,613 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936754808,894 - 828,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3301,584 - 321,712 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13296,399 - 322,967 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23152,233 - 170,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pdgfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,169,064 - 26,188,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,172,808 - 26,191,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PDGFA
553 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 19 35 35 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000015628   ⟹   ENSCSAP00000013561
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2821,047,219 - 21,069,827 (+)Ensembl
RefSeq Acc Id: XM_008018923   ⟹   XP_008017114
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12821,044,549 - 21,068,411 (+)NCBI
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018924   ⟹   XP_008017115
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12821,045,062 - 21,068,411 (+)NCBI
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018925   ⟹   XP_008017116
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12821,045,064 - 21,068,411 (+)NCBI
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018926   ⟹   XP_008017117
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12821,048,282 - 21,068,411 (+)NCBI
Vero_WHO_p1.0NW_023666090605,283 - 626,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018927   ⟹   XP_008017118
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12821,046,520 - 21,068,411 (+)NCBI
Vero_WHO_p1.0NW_023666090605,283 - 627,869 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037995179   ⟹   XP_037851107
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBI
RefSeq Acc Id: XP_008017114   ⟸   XM_008018923
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008017115   ⟸   XM_008018924
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008017116   ⟸   XM_008018925
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008017118   ⟸   XM_008018927
- Peptide Label: isoform X6
RefSeq Acc Id: XP_008017117   ⟸   XM_008018926
- Peptide Label: isoform X5
Ensembl Acc Id: ENSCSAP00000013561   ⟸   ENSCSAT00000015628
RefSeq Acc Id: XP_037851107   ⟸   XM_037995179
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015628.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  PD_growth_factor_CS UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/TrEMBL
  PDGF_N UniProtKB/TrEMBL
NCBI Gene PDGFA ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR UniProtKB/TrEMBL
  PLATELET-DERIVED GROWTH FACTOR SUBUNIT A UniProtKB/TrEMBL
Pfam PDGF UniProtKB/TrEMBL
  PDGF_N UniProtKB/TrEMBL
PROSITE PDGF_1 UniProtKB/TrEMBL
  PDGF_2 UniProtKB/TrEMBL
SMART PDGF UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0D9RY72_CHLSB UniProtKB/TrEMBL