SHOX2 (SHOX homeobox 2) - Rat Genome Database

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Gene: SHOX2 (SHOX homeobox 2) Chlorocebus sabaeus
Analyze
Symbol: SHOX2
Name: SHOX homeobox 2 (Ensembl:short stature homeobox 2)
RGD ID: 18778502
Description: ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN cardiac atrium morphogenesis (ortholog); cartilage development involved in endochondral bone morphogenesis (ortholog); chondrocyte development (ortholog); ASSOCIATED WITH cleft palate (ortholog); genetic disease (ortholog); Leri-Weill dyschondrosteosis (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: short stature homeobox 2; short stature homeobox protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11532,684,598 - 32,694,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1532,684,705 - 32,692,699 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660415,251,405 - 5,261,933 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SHOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11532,684,598 - 32,694,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1532,684,705 - 32,692,699 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660415,251,405 - 5,261,933 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SHOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383158,095,905 - 158,106,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3158,095,905 - 158,106,420 (-)EnsemblGRCh38hg38GRCh38
GRCh373157,813,694 - 157,824,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363159,296,494 - 159,306,630 (-)NCBINCBI36Build 36hg18NCBI36
Build 343159,297,570 - 159,306,541NCBI
Celera3156,237,551 - 156,247,714 (-)NCBICelera
Cytogenetic Map3q25.32NCBI
HuRef3155,210,551 - 155,220,711 (-)NCBIHuRef
CHM1_13157,777,104 - 157,787,273 (-)NCBICHM1_1
T2T-CHM13v2.03160,870,630 - 160,881,158 (-)NCBIT2T-CHM13v2.0
Shox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39366,879,056 - 66,889,104 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl366,879,060 - 66,889,104 (-)EnsemblGRCm39 Ensembl
GRCm38366,971,723 - 66,981,771 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl366,971,727 - 66,981,771 (-)EnsemblGRCm38mm10GRCm38
MGSCv37366,777,188 - 66,785,693 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36367,061,195 - 67,069,700 (-)NCBIMGSCv36mm8
Celera367,108,915 - 67,117,391 (-)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.76NCBI
Shox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82153,524,324 - 153,537,571 (-)NCBIGRCr8
mRatBN7.22151,217,049 - 151,227,180 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2151,217,552 - 151,227,143 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2158,353,974 - 158,363,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02156,404,472 - 156,414,073 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02151,037,220 - 151,046,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02164,118,175 - 164,126,783 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2164,118,191 - 164,126,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02183,469,813 - 183,478,421 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42156,881,044 - 156,889,653 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12156,831,006 - 156,839,616 (-)NCBI
Celera2145,597,026 - 145,605,637 (-)NCBICelera
Cytogenetic Map2q31NCBI
Shox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554488,937,610 - 8,947,890 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554488,937,656 - 8,947,890 (-)NCBIChiLan1.0ChiLan1.0
SHOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,001,278 - 156,011,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13156,005,878 - 156,016,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03155,138,969 - 155,149,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13163,190,277 - 163,199,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3163,190,284 - 163,199,239 (-)Ensemblpanpan1.1panPan2
SHOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12351,484,696 - 51,492,586 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2351,484,421 - 51,492,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2351,357,238 - 51,365,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02352,123,573 - 52,131,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2352,123,242 - 52,131,401 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12351,703,428 - 51,711,464 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02351,755,484 - 51,763,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02352,041,698 - 52,049,712 (-)NCBIUU_Cfam_GSD_1.0
Shox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560284,914,738 - 84,925,145 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365194,809,687 - 4,818,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365194,810,777 - 4,818,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1397,879,281 - 97,889,785 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11397,879,586 - 97,892,276 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213106,074,270 - 106,084,447 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Shox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473035,825,922 - 35,835,756 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473035,826,631 - 35,836,141 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 6 11
Below cutoff 21 6 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010208   ⟹   ENSCSAP00000008305
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1532,684,705 - 32,692,699 (+)Ensembl
RefSeq Acc Id: XM_008008576   ⟹   XP_008006767
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11532,684,598 - 32,694,640 (+)NCBI
Vero_WHO_p1.0NW_0236660415,251,405 - 5,261,933 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008006767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008305.1
Reference Protein Sequences
RefSeq Acc Id: XP_008006767   ⟸   XM_008008576
RefSeq Acc Id: ENSCSAP00000008305   ⟸   ENSCSAT00000010208


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010208.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  HTH_motif UniProtKB/TrEMBL
  OAR_dom UniProtKB/TrEMBL
KEGG Report csab:103241415 UniProtKB/TrEMBL
NCBI Gene SHOX2 ENTREZGENE
PANTHER SHORT STATURE HOMEOBOX UniProtKB/TrEMBL
  SHORT STATURE HOMEOBOX PROTEIN 2 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
PRINTS HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0D9RI66_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-13 SHOX2  SHOX homeobox 2  SHOX2  short stature homeobox 2  Symbol and/or name change 5135510 APPROVED