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Gene: HSPB1 (heat shock protein family B (small) member 1) Chlorocebus sabaeus

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Symbol:

HSPB1

Name:

heat shock protein family B (small) member 1

RGD ID:

18777983

Description:

ENCODES a protein that exhibits ubiquitin binding (ortholog); INVOLVED IN cellular response to butyrate (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to interleukin-11 (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autosomal dominant distal hereditary motor neuronopathy 2 (ortholog); FOUND IN axon (ortholog); cardiac myofibril (ortholog); cornified envelope (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock protein beta-1; heat shock protein beta-1 pseudogene; LOC103246660; LOC103246661

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,442,530 - 10,443,804 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	10,442,398 - 10,443,855 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	5,976,665 - 5,978,438 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Alzheimer's disease (ISO)

autosomal dominant distal hereditary motor neuronopathy 2 (ISO)

autosomal dominant distal hereditary motor neuronopathy 3 (ISO)

Brain Injuries (ISO)

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease axonal type 2F (ISO)

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

Charcot-Marie-Tooth disease type 4 (ISO)

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

Colonic Neoplasms (ISO)

congestive heart failure (ISO)

contact dermatitis (ISO)

Diabetic Nephropathies (ISO)

Fever (ISO)

focal segmental glomerulosclerosis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Hyperplasia (ISO)

hypertrophic cardiomyopathy (ISO)

Intracranial Hemorrhages (ISO)

Liver Injury (ISO)

lung adenocarcinoma (ISO)

Mouth Neoplasms (ISO)

multiple myeloma (ISO)

pancreatic cancer (ISO)

pleomorphic xanthoastrocytoma (ISO)

Presbycusis (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

Retina Reperfusion Injury (ISO)

rheumatoid arthritis (ISO)

sarcoma (ISO)

Spinal Cord Injuries (ISO)

spinal muscular atrophy (ISO)

squamous cell carcinoma (ISO)

status epilepticus (ISO)

Stomach Neoplasms (ISO)

Tongue Neoplasms (ISO)

transient cerebral ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde axonal protein transport (IEA)

cellular response to butyrate (ISO)

cellular response to hydrogen peroxide (ISO)

cellular response to interleukin-11 (ISO)

cellular response to vascular endothelial growth factor stimulus (IEA)

chaperone-mediated protein folding (IEA)

female pregnancy (ISO)

intracellular signal transduction (IEA)

negative regulation of apoptotic process (IEA)

negative regulation of apoptotic signaling pathway (IEA,ISO)

negative regulation of cellular response to oxidative stress (ISO)

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (IEA)

negative regulation of protein kinase activity (ISO)

negative regulation of regulatory T cell differentiation (ISO)

platelet aggregation (ISO)

positive regulation of angiogenesis (IEA)

positive regulation of blood vessel endothelial cell migration (IEA)

positive regulation of endothelial cell chemotaxis (IEA)

positive regulation of interleukin-1 beta production (IEA)

positive regulation of neuron projection development (ISO)

positive regulation of tumor necrosis factor production (IEA)

protein refolding (IEA)

regulation of canonical NF-kappaB signal transduction (IEA)

regulation of protein phosphorylation (ISO)

response to angiotensin (ISO)

response to heat (IEA)

response to ischemia (ISO)

response to muscle stretch (ISO)

response to virus (IEA)

vascular endothelial growth factor receptor signaling pathway (IEA)

Cellular Component

axon (ISO)

axon cytoplasm (IEA)

cardiac myofibril (ISO)

contractile muscle fiber (IEA)

cornified envelope (IEA,ISO)

cytoplasm (IEA)

dendrite (ISO)

I band (ISO)

M band (ISO)

nucleus (IEA)

perikaryon (ISO)

plasma membrane (IEA)

postsynaptic density membrane (ISO)

proteasome complex (ISO)

Z disc (IEA)

Molecular Function

identical protein binding (IEA)

protein binding (ISO)

protein folding chaperone (IEA)

protein homodimerization activity (IEA)

protein kinase binding (IEA)

protein kinase C binding (IEA)

protein kinase C inhibitor activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

ubiquitin binding (ISO)

unfolded protein binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

HSPB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,442,530 - 10,443,804 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	10,442,398 - 10,443,855 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	5,976,665 - 5,978,438 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HSPB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	76,302,673 - 76,304,292 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	76,302,673 - 76,305,813 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	75,931,990 - 75,933,609 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	75,769,859 - 75,771,548 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	75,576,573 - 75,578,263	NCBI
Celera	7	70,800,374 - 70,802,113 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,018,196 - 71,019,935 (+)	NCBI		HuRef
CHM1_1	7	75,861,968 - 75,863,707 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	77,590,142 - 77,591,761 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	75,264,939 - 75,266,678 (+)	NCBI

Hspb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,916,773 - 135,918,417 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,916,773 - 135,918,417 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,887,919 - 135,889,563 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,887,919 - 135,889,563 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	136,363,789 - 136,365,433 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	136,172,686 - 136,174,064 (+)	NCBI		MGSCv36	mm8
Celera	5	132,896,482 - 132,898,126 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.51	NCBI

Hspb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,430,640 - 26,432,301 (-)	NCBI		GRCr8
mRatBN7.2	12	20,794,014 - 20,795,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,794,028 - 20,795,743 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	21,935,462 - 21,937,122 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	22,547,858 - 22,549,518 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	21,613,792 - 21,615,453 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	23,839,390 - 23,841,051 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,839,399 - 23,841,049 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	25,837,102 - 25,838,663 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	21,911,223 - 21,912,784 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	21,898,486 - 21,900,048 (-)	NCBI
Celera	12	22,557,404 - 22,559,067 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Hspb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955844	7,790 - 10,004 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955844	8,094 - 9,565 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSPB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	93,649,270 - 93,652,551 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	141,913,908 - 141,916,004 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	67,716,021 - 67,717,762 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,751,385 - 82,753,109 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,751,523 - 82,752,984 (+)	Ensembl	panpan1.1		panPan2

HSPB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	7,487,164 - 7,488,576 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	7,487,250 - 7,488,576 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	9,182,749 - 9,184,173 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	7,307,626 - 7,309,048 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	7,307,712 - 7,309,048 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	7,276,667 - 7,278,079 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	7,239,649 - 7,241,061 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	7,403,114 - 7,404,545 (+)	NCBI		UU_Cfam_GSD_1.0

Hspb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,924,637 - 131,926,212 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,110,304 - 2,112,186 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,110,351 - 2,111,896 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSPB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,037,949 - 10,039,704 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,038,074 - 10,039,441 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	9,925,991 - 9,927,359 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hspb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,939,445 - 14,941,819 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,940,161 - 14,941,561 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HSPB1
12 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008018402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037990466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000016233 ⟹ ENSCSAP00000014155

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	28	10,442,398 - 10,443,855 (+)	Ensembl

RefSeq Acc Id:

XM_037990466 ⟹ XP_037846394

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666070	5,976,665 - 5,978,438 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_037846394	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014155.1

Ensembl Acc Id:

ENSCSAP00000014155 ⟸ ENSCSAT00000016233

RefSeq Acc Id:

XP_037846394 ⟸ XM_037990466

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018137	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000016233.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.790	UniProtKB/TrEMBL
InterPro	A-crystallin/Hsp20_dom	UniProtKB/TrEMBL
	Alpha-crystallin/sHSP_animal	UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/TrEMBL
KEGG Report	csab:103246661	UniProtKB/TrEMBL
NCBI Gene	LOC103246661	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN BETA-1	UniProtKB/TrEMBL
	PTHR45640	UniProtKB/TrEMBL
Pfam	HSP20	UniProtKB/TrEMBL
PRINTS	ACRYSTALLIN	UniProtKB/TrEMBL
PROSITE	SHSP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49764	UniProtKB/TrEMBL
UniProt	A0A0D9RZW6_CHLSB	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	HSPB1	heat shock protein family B (small) member 1	LOC103246661	heat shock protein beta-1	Symbol and/or name change	5135510	APPROVED
2020-12-03	LOC103246661	heat shock protein beta-1	LOC103246660	heat shock protein beta-1 pseudogene	Data merged from RGD:18718985	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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