PHLDA3 (pleckstrin homology like domain family A member 3) - Rat Genome Database

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Gene: PHLDA3 (pleckstrin homology like domain family A member 3) Chlorocebus sabaeus
Analyze
Symbol: PHLDA3
Name: pleckstrin homology like domain family A member 3
RGD ID: 18776940
Description: ENCODES a protein that exhibits phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); phosphatidylinositol-3,5-bisphosphate binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (inferred); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (inferred); positive regulation of apoptotic process (inferred); ASSOCIATED WITH familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology-like domain family A member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,945,013 - 27,948,870 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,945,608 - 27,945,991 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,740,957 - 28,744,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PHLDA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,945,013 - 27,948,870 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,945,608 - 27,945,991 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,740,957 - 28,744,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PHLDA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,464,278 - 201,469,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,464,278 - 201,469,237 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,433,406 - 201,438,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,701,245 - 199,704,922 (-)NCBINCBI36Build 36hg18NCBI36
Build 341198,166,279 - 198,169,956NCBI
Celera1174,558,492 - 174,562,169 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,600,628 - 172,604,316 (-)NCBIHuRef
CHM1_11202,856,735 - 202,860,431 (-)NCBICHM1_1
T2T-CHM13v2.01200,722,059 - 200,726,971 (-)NCBIT2T-CHM13v2.0
Phlda3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,693,823 - 135,696,872 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,693,857 - 135,696,874 (+)EnsemblGRCm39 Ensembl
GRCm381135,766,085 - 135,769,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,766,119 - 135,769,136 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,662,662 - 137,665,711 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,582,544 - 137,585,545 (+)NCBIMGSCv36mm8
Celera1138,400,219 - 138,403,272 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.26NCBI
Phlda3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,745,003 - 49,748,088 (+)NCBIGRCr8
mRatBN7.21347,193,250 - 47,196,335 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,193,086 - 47,196,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,802,074 - 49,805,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,090,139 - 51,093,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,353,354 - 48,356,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,588,917 - 52,592,002 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,588,917 - 52,592,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,637,217 - 57,640,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,789,678 - 48,793,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,803,734 - 48,808,041 (+)NCBI
Celera1347,510,714 - 47,513,799 (+)NCBICelera
Cytogenetic Map13q13NCBI
Phlda3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,579,006 - 37,582,230 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,579,006 - 37,582,230 (-)NCBIChiLan1.0ChiLan1.0
PHLDA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,912,241 - 47,916,187 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,876,910 - 47,880,873 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,063,775 - 177,067,714 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,365,063 - 181,368,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,367,976 - 181,368,359 (-)Ensemblpanpan1.1panPan2
PHLDA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,438,539 - 1,440,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,488,304 - 1,490,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.071,444,885 - 1,447,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,444,921 - 1,445,304 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,432,439 - 1,434,920 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,540,393 - 1,542,879 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,564,820 - 1,567,301 (+)NCBIUU_Cfam_GSD_1.0
Phlda3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,746,903 - 73,750,232 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,981,602 - 2,984,903 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,981,632 - 2,984,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLDA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,826,874 - 23,827,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,824,181 - 23,827,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,232,722 - 28,235,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Phlda3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,259,456 - 9,262,531 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,259,437 - 9,262,528 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 19 16
Low 17 19 44
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007988970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000018282   ⟹   ENSCSAP00000017743
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2527,945,608 - 27,945,991 (+)Ensembl
RefSeq Acc Id: XM_007988970   ⟹   XP_007987161
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12527,945,013 - 27,948,870 (+)NCBI
Vero_WHO_p1.0NW_02366605528,740,957 - 28,744,831 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007987161 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017743
  ENSCSAP00000017743.1
Reference Protein Sequences
RefSeq Acc Id: XP_007987161   ⟸   XM_007988970
- UniProtKB: A0A0D9SA54 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017743   ⟸   ENSCSAT00000018282


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018282.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PHLA1/2/3 UniProtKB/TrEMBL
KEGG Report csab:103230329 UniProtKB/TrEMBL
NCBI Gene PHLDA3 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 3 UniProtKB/TrEMBL
  PTHR15478 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A0D9SA54 ENTREZGENE, UniProtKB/TrEMBL