EPC2 (enhancer of polycomb homolog 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: EPC2 (enhancer of polycomb homolog 2) Chlorocebus sabaeus
Analyze
Symbol: EPC2
Name: enhancer of polycomb homolog 2
RGD ID: 18776576
Description: INVOLVED IN chromatin organization (inferred); positive regulation of double-strand break repair via homologous recombination (inferred); regulation of cell cycle (inferred); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 1 (ortholog); genetic disease (ortholog); type 2 diabetes mellitus (ortholog); FOUND IN NuA4 histone acetyltransferase complex (ortholog); nucleosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,046,966 - 34,190,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,047,028 - 34,191,956 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,321,145 - 165,465,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
EPC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,046,966 - 34,190,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,047,028 - 34,191,956 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,321,145 - 165,465,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,644,751 - 148,787,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,644,440 - 148,787,569 (+)EnsemblGRCh38hg38GRCh38
GRCh372149,402,320 - 149,545,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362149,119,038 - 149,261,606 (+)NCBINCBI36Build 36hg18NCBI36
Build 342149,236,299 - 149,378,867NCBI
Celera2143,116,707 - 143,259,286 (+)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2141,400,948 - 141,543,639 (+)NCBIHuRef
CHM1_12149,408,018 - 149,550,591 (+)NCBICHM1_1
T2T-CHM13v2.02149,095,135 - 149,237,987 (+)NCBIT2T-CHM13v2.0
Epc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39249,341,498 - 49,441,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl249,341,498 - 49,441,960 (+)EnsemblGRCm39 Ensembl
GRCm38249,450,755 - 49,551,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl249,451,486 - 49,551,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv37249,307,006 - 49,407,129 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,273,525 - 49,373,192 (+)NCBIMGSCv36mm8
Celera251,125,040 - 51,224,667 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.62NCBI
Epc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8354,276,187 - 54,376,373 (+)NCBIGRCr8
mRatBN7.2333,867,219 - 33,967,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,867,219 - 33,967,150 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx337,245,306 - 37,338,792 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,830,029 - 45,923,519 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,642,087 - 43,735,614 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0333,641,616 - 33,741,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,641,616 - 33,740,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,799,078 - 38,898,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4330,420,605 - 30,536,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1330,316,765 - 30,433,028 (+)NCBI
Celera332,058,204 - 32,153,476 (+)NCBICelera
Cytogenetic Map3q12NCBI
Epc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,573,960 - 14,646,431 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544014,573,960 - 14,645,171 (+)NCBIChiLan1.0ChiLan1.0
EPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,140,608 - 26,284,335 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,155,574 - 26,299,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,074,397 - 11,218,181 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B153,005,269 - 153,148,789 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B153,005,176 - 153,148,644 (+)Ensemblpanpan1.1panPan2
EPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11950,356,490 - 50,484,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,416,340 - 50,482,878 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1950,480,600 - 50,607,918 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,829,735 - 51,957,381 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,839,014 - 51,956,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,474,115 - 50,601,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,609,141 - 50,736,678 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01952,016,983 - 52,134,906 (+)NCBIUU_Cfam_GSD_1.0
Epc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,991,745 - 113,128,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,488,377 - 28,625,975 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,489,620 - 28,625,975 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,417,063 - 3,526,171 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,417,446 - 3,526,223 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2152,980,941 - 3,121,134 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Epc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,301,584 - 1,452,825 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248661,301,922 - 1,451,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 24 2 46
Low 12 18 14
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014263   ⟹   ENSCSAP00000012239
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1034,047,028 - 34,191,956 (+)Ensembl
RefSeq Acc Id: XM_007964942   ⟹   XP_007963133
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11034,046,966 - 34,190,829 (+)NCBI
Vero_WHO_p1.0NW_023666040165,321,145 - 165,465,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964943   ⟹   XP_007963134
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11034,046,966 - 34,190,829 (+)NCBI
Vero_WHO_p1.0NW_023666040165,321,145 - 165,465,454 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007963133 (Get FASTA)   NCBI Sequence Viewer  
  XP_007963134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012239
  ENSCSAP00000012239.1
Reference Protein Sequences
RefSeq Acc Id: XP_007963133   ⟸   XM_007964942
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RUF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007963134   ⟸   XM_007964943
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000012239   ⟸   ENSCSAT00000014263


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016167 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014263.1 UniProtKB/TrEMBL
InterPro Enhancer_polycomb UniProtKB/TrEMBL
  Enhancer_polycomb-like_N UniProtKB/TrEMBL
  Enhancer_polycomb_C UniProtKB/TrEMBL
KEGG Report csab:103217058 UniProtKB/TrEMBL
NCBI Gene EPC2 ENTREZGENE
PANTHER ENHANCER OF POLYCOMB HOMOLOG 2 UniProtKB/TrEMBL
  PTHR14898 UniProtKB/TrEMBL
Pfam E_Pc_C UniProtKB/TrEMBL
  EPL1 UniProtKB/TrEMBL
UniProt A0A0D9RUF0 ENTREZGENE, UniProtKB/TrEMBL