CYP4F3 (cytochrome P450 family 4 subfamily F member 3) - Rat Genome Database

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Gene: CYP4F3 (cytochrome P450 family 4 subfamily F member 3) Chlorocebus sabaeus
Analyze
Symbol: CYP4F3
Name: cytochrome P450 family 4 subfamily F member 3
RGD ID: 18767751
Description: ENCODES a protein that exhibits 20-aldehyde-leukotriene B4 20-monooxygenase activity (ortholog); 20-hydroxy-leukotriene B4 omega oxidase activity (ortholog); leukotriene-B4 20-monooxygenase activity (ortholog); INVOLVED IN fatty acid omega-oxidation (ortholog); leukotriene B4 catabolic process (ortholog); leukotriene B4 metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Poisoning (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450 4F2; cytochrome P450 4F3; leukotriene-B(4) omega-hydroxylase 1; leukotriene-B(4) omega-hydroxylase 2; LOC103234079
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,241,352 - 14,260,799 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,241,409 - 14,263,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,238,620 - 5,257,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Poisoning  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CYP4F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,241,352 - 14,260,799 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,241,409 - 14,263,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,238,620 - 5,257,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CYP4F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,640,897 - 15,662,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,640,897 - 15,662,825 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,751,707 - 15,773,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,612,707 - 15,632,570 (+)NCBINCBI36Build 36hg18NCBI36
Build 341915,612,706 - 15,634,634NCBI
Celera1915,648,618 - 15,668,477 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1915,320,174 - 15,340,137 (+)NCBIHuRef
CHM1_11915,751,200 - 15,771,063 (+)NCBICHM1_1
T2T-CHM13v2.01915,766,167 - 15,788,209 (+)NCBIT2T-CHM13v2.0
Cyp4f18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,742,326 - 72,763,512 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,742,326 - 72,763,470 (-)EnsemblGRCm39 Ensembl
GRCm38871,988,482 - 72,009,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,988,482 - 72,009,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,512,381 - 74,533,525 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,917,471 - 74,938,606 (-)NCBIMGSCv36mm8
Celera876,344,833 - 76,358,866 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.67NCBI
Cyp4f18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,797,558 - 17,838,958 (+)NCBIGRCr8
mRatBN7.21617,763,543 - 17,804,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,707,317 - 17,804,940 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,829,506 - 17,857,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,962,528 - 18,990,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,882,424 - 17,910,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,501,680 - 19,528,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,410,810 - 19,528,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,358,299 - 19,385,553 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,183,761 - 18,225,158 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,197,585 - 18,224,006 (+)NCBI
Celera1617,986,320 - 18,013,579 (+)NCBICelera
Cytogenetic Map16p14NCBI
CYP4F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,545,248 - 20,566,863 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,548,098 - 19,568,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01915,162,886 - 15,182,334 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11916,146,664 - 16,165,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,146,664 - 16,165,869 (+)Ensemblpanpan1.1panPan2
LOC484867
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,611,799 - 46,664,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,458,620 - 46,705,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,491,933 - 46,513,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,130,943 - 47,152,195 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,098,253 - 47,151,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,365,840 - 46,387,293 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,784,998 - 46,803,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,058,563 - 47,076,586 (-)NCBIUU_Cfam_GSD_1.0
LOC110259329
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,864,575 - 61,984,903 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,863,378 - 61,884,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 5 1 5
Low 15 19 15
Below cutoff 3 17

Sequence


Ensembl Acc Id: ENSCSAT00000004001   ⟹   ENSCSAP00000002264
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl614,241,409 - 14,263,494 (+)Ensembl
RefSeq Acc Id: XM_007995608   ⟹   XP_007993799
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1614,241,352 - 14,260,799 (+)NCBI
Vero_WHO_p1.0NW_0236660745,238,620 - 5,257,735 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995610   ⟹   XP_007993801
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1614,244,699 - 14,259,953 (+)NCBI
Vero_WHO_p1.0NW_0236660745,238,620 - 5,254,830 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037992479   ⟹   XP_037848407
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660745,238,620 - 5,257,736 (-)NCBI
RefSeq Acc Id: XM_037992480   ⟹   XP_037848408
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660745,238,620 - 5,257,739 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007993799 (Get FASTA)   NCBI Sequence Viewer  
  XP_007993801 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848407 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848408 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002264.1
RefSeq Acc Id: XP_007993799   ⟸   XM_007995608
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R0X5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993801   ⟸   XM_007995610
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R0X5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002264   ⟸   ENSCSAT00000004001
RefSeq Acc Id: XP_037848408   ⟸   XM_037992480
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037848407   ⟸   XM_037992479
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R0X5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005964 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004001.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_Monoox UniProtKB/TrEMBL
NCBI Gene LOC103234079 ENTREZGENE
PANTHER CYTOCHROME P450 4F2 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0D9R0X5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:83411 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP4F3  cytochrome P450 family 4 subfamily F member 3  LOC103234079  leukotriene-B(4) omega-hydroxylase 2  Symbol and/or name change 5135510 APPROVED