ANO2 (anoctamin 2) - Rat Genome Database

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Gene: ANO2 (anoctamin 2) Chlorocebus sabaeus
Analyze
Symbol: ANO2
Name: anoctamin 2
RGD ID: 18766790
Description: ENCODES a protein that exhibits identical protein binding (ortholog); intracellularly calcium-gated chloride channel activity (ortholog); phospholipid scramblase activity (ortholog); INVOLVED IN chloride transport (ortholog); establishment of localization in cell (ortholog); ASSOCIATED WITH episodic ataxia type 1 (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); lymphoproliferative syndrome 2 (ortholog); FOUND IN glutamatergic synapse (ortholog); neuron projection (ortholog); non-motile cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: anoctamin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,610,509 - 5,970,580 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,611,162 - 5,969,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,246,131 - 2,623,038 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ANO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,610,509 - 5,970,580 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,611,162 - 5,969,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,246,131 - 2,623,038 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ANO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,562,655 - 5,946,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,531,869 - 5,946,232 (-)EnsemblGRCh38hg38GRCh38
GRCh37125,671,821 - 6,055,398 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,542,081 - 5,925,659 (-)NCBINCBI36Build 36hg18NCBI36
Build 34125,542,080 - 5,925,659NCBI
Celera127,292,577 - 7,675,047 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef125,525,403 - 5,907,364 (-)NCBIHuRef
CHM1_1125,671,608 - 6,054,794 (-)NCBICHM1_1
T2T-CHM13v2.0125,569,523 - 5,953,779 (-)NCBIT2T-CHM13v2.0
Ano2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,667,382 - 126,017,115 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,667,382 - 126,017,089 (+)EnsemblGRCm39 Ensembl
GRCm386125,690,419 - 126,040,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,690,419 - 126,040,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,640,437 - 125,990,151 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,676,322 - 126,005,752 (+)NCBIMGSCv36mm8
MGSCv366126,602,651 - 126,934,718 (+)NCBIMGSCv36mm8
Celera6127,350,653 - 127,704,257 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.58NCBI
Ano2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84160,200,471 - 160,541,830 (+)NCBIGRCr8
mRatBN7.24158,514,200 - 158,855,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,496,014 - 158,855,651 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04158,222,650 - 158,577,595 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,224,000 - 158,576,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,312,041 - 225,579,493 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,315,059 - 162,376,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4147,226,836 - 147,581,598 (+)NCBICelera
Cytogenetic Map4q42NCBI
Ano2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,333,289 - 3,668,587 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,333,275 - 3,650,255 (-)NCBIChiLan1.0ChiLan1.0
ANO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,117,549 - 11,501,548 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,114,307 - 11,498,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,690,023 - 6,071,283 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,608,895 - 5,987,004 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,609,541 - 5,987,900 (-)Ensemblpanpan1.1panPan2
ANO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,976,761 - 39,320,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,295,718 - 7,637,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,333,634 - 39,677,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,332,399 - 39,697,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12739,204,162 - 39,546,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02739,246,081 - 39,587,939 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,773,567 - 7,115,529 (-)NCBIUU_Cfam_GSD_1.0
Ano2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945103,078,168 - 103,430,124 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,745,804 - 2,096,989 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,771,763 - 2,097,668 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Ano2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248602,531,904 - 2,854,862 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,531,196 - 2,835,248 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2
Low 19 15 52
Below cutoff 16 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008891   ⟹   ENSCSAP00000007025
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl115,611,162 - 5,969,478 (-)Ensembl
RefSeq Acc Id: XM_037988687   ⟹   XP_037844615
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660632,246,131 - 2,623,038 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037844615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007025.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000007025   ⟸   ENSCSAT00000008891
RefSeq Acc Id: XP_037844615   ⟸   XM_037988687
- UniProtKB: A0A0D9REI6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010915 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008891.1 UniProtKB/TrEMBL
InterPro Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
  Anoctamin_TM UniProtKB/TrEMBL
NCBI Gene ANO2 ENTREZGENE
PANTHER PTHR12308 UniProtKB/TrEMBL
  PTHR12308:SF20 UniProtKB/TrEMBL
Pfam Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
UniProt A0A0D9REI6 ENTREZGENE, UniProtKB/TrEMBL