GMPS (guanine monophosphate synthase) - Rat Genome Database

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Gene: GMPS (guanine monophosphate synthase) Chlorocebus sabaeus
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Symbol: GMPS
Name: guanine monophosphate synthase
RGD ID: 18764788
Description: ENCODES a protein that exhibits enzyme binding (ortholog); GMP synthase (glutamine-hydrolyzing) activity (ortholog); GMP synthase activity (ortholog); INVOLVED IN GMP biosynthetic process (ortholog); GMP salvage (ortholog); response to L-cysteine (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH acute myelomonocytic leukemia (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GMP synthase [glutamine-hydrolyzing]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11534,817,603 - 34,885,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1534,815,066 - 34,885,228 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660417,450,006 - 7,520,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GMPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11534,817,603 - 34,885,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1534,815,066 - 34,885,228 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660417,450,006 - 7,520,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GMPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,869,430 - 155,944,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3155,870,650 - 155,944,020 (+)EnsemblGRCh38hg38GRCh38
GRCh373155,588,439 - 155,661,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363157,071,019 - 157,138,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 343157,071,026 - 157,138,223NCBI
Celera3154,009,947 - 154,077,188 (+)NCBICelera
Cytogenetic Map3q25.31NCBI
HuRef3152,982,759 - 153,049,917 (+)NCBIHuRef
CHM1_13155,551,614 - 155,618,831 (+)NCBICHM1_1
T2T-CHM13v2.03158,644,070 - 158,718,668 (+)NCBIT2T-CHM13v2.0
Gmps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,871,054 - 63,928,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,883,527 - 63,930,000 (+)EnsemblGRCm39 Ensembl
GRCm38363,963,633 - 64,021,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,976,106 - 64,022,579 (+)EnsemblGRCm38mm10GRCm38
MGSCv37363,780,065 - 63,823,000 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36364,064,072 - 64,107,007 (+)NCBIMGSCv36mm8
Celera363,647,946 - 63,691,053 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.08NCBI
Gmps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82150,587,824 - 150,641,564 (+)NCBIGRCr8
mRatBN7.22148,441,369 - 148,491,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2148,435,643 - 148,485,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2155,179,955 - 155,214,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02153,229,417 - 153,264,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,862,091 - 147,896,832 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02154,555,967 - 154,590,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2154,555,871 - 154,590,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,939,844 - 173,974,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,804,512 - 153,840,009 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12153,754,474 - 153,789,970 (+)NCBI
Celera2142,726,833 - 142,761,299 (+)NCBICelera
Cytogenetic Map2q31NCBI
Gmps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554486,932,926 - 6,984,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554486,931,891 - 6,984,662 (+)NCBIChiLan1.0ChiLan1.0
GMPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22153,783,747 - 153,852,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13153,788,477 - 153,862,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03152,925,905 - 152,999,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,977,222 - 161,045,214 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,977,222 - 161,045,214 (+)Ensemblpanpan1.1panPan2
GMPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12349,569,571 - 49,645,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2349,569,531 - 49,699,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2349,445,713 - 49,522,068 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02350,203,908 - 50,286,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2350,203,868 - 50,333,624 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,789,609 - 49,866,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02349,838,479 - 49,915,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02350,126,162 - 50,202,992 (+)NCBIUU_Cfam_GSD_1.0
Gmps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560286,587,606 - 86,639,212 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365193,104,701 - 3,141,549 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365193,094,763 - 3,143,322 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GMPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1395,738,659 - 95,819,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11395,742,342 - 95,820,903 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213103,766,547 - 103,819,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gmps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473033,460,566 - 33,535,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473033,459,059 - 33,535,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 58
Low 20 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000010111   ⟹   ENSCSAP00000008209
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1534,815,066 - 34,885,228 (-)Ensembl
RefSeq Acc Id: XM_008008622   ⟹   XP_008006813
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11534,817,603 - 34,885,363 (-)NCBI
Vero_WHO_p1.0NW_0236660417,450,006 - 7,520,263 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038002672   ⟹   XP_037858600
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660417,450,006 - 7,504,273 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008006813 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858600 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008209
  ENSCSAP00000008209.1
RefSeq Acc Id: XP_008006813   ⟸   XM_008008622
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RHX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008209   ⟸   ENSCSAT00000010111
RefSeq Acc Id: XP_037858600   ⟸   XM_038002672
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010111.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
InterPro Class_I_gatase-like UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
  GMP_synth_C UniProtKB/TrEMBL
  GMP_synth_GATase UniProtKB/TrEMBL
  GMPS_ATP_PPase_dom UniProtKB/TrEMBL
  NAD/GMP_synthase UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
KEGG Report csab:103241435 UniProtKB/TrEMBL
NCBI Gene GMPS ENTREZGENE
PANTHER GMP SYNTHASE [GLUTAMINE-HYDROLYZING] UniProtKB/TrEMBL
  GMP SYNTHASE-RELATED UniProtKB/TrEMBL
Pfam GATase UniProtKB/TrEMBL
  GMP_synt_C UniProtKB/TrEMBL
  NAD_synthase UniProtKB/TrEMBL
PRINTS ANTSNTHASEII UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
PROSITE GATASE_TYPE_1 UniProtKB/TrEMBL
  GMPS_ATP_PPASE UniProtKB/TrEMBL
Superfamily-SCOP Adenine nucleotide alpha hydrolases-like UniProtKB/TrEMBL
  GMP synthetase C-terminal dimerisation domain UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
UniProt A0A0D9RHX0 ENTREZGENE, UniProtKB/TrEMBL