MYCL (MYCL proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: MYCL (MYCL proto-oncogene, bHLH transcription factor) Chlorocebus sabaeus
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Symbol: MYCL
Name: MYCL proto-oncogene, bHLH transcription factor
RGD ID: 18762484
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN regulation of inner ear auditory receptor cell differentiation (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); lung small cell carcinoma (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein L-Myc; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,998,668 - 93,005,283 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,999,219 - 93,005,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603323,836,433 - 23,843,547 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYCL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,998,668 - 93,005,283 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,999,219 - 93,005,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603323,836,433 - 23,843,547 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MYCL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38139,895,428 - 39,901,917 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl139,895,428 - 39,902,256 (-)EnsemblGRCh38hg38GRCh38
GRCh37140,361,100 - 40,367,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,133,685 - 40,140,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 34140,034,494 - 40,036,668NCBI
Celera138,642,539 - 38,649,130 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,479,732 - 38,486,323 (-)NCBIHuRef
CHM1_1140,476,747 - 40,483,338 (-)NCBICHM1_1
T2T-CHM13v2.0139,764,868 - 39,771,357 (-)NCBIT2T-CHM13v2.0
Mycl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,889,414 - 122,896,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,889,445 - 122,896,278 (+)EnsemblGRCm39 Ensembl
GRCm384122,995,588 - 123,002,490 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,995,652 - 123,002,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv374122,673,342 - 122,679,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,498,402 - 122,504,788 (+)NCBIMGSCv36mm8
Celera4121,326,161 - 121,332,547 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.36NCBI
Mycl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,559,843 - 140,566,704 (+)NCBIGRCr8
mRatBN7.25135,274,713 - 135,281,584 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,274,748 - 135,281,582 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,982,262 - 137,986,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,752,252 - 139,756,249 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,759,366 - 139,763,363 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,691,947 - 140,698,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,692,779 - 140,698,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,482,446 - 144,489,315 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,311,233 - 142,315,233 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5133,813,704 - 133,817,704 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mycl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,389,796 - 17,397,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545217,390,285 - 17,397,115 (-)NCBIChiLan1.0ChiLan1.0
MYCL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,920,842 - 186,927,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11186,058,475 - 186,065,011 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,184,883 - 39,191,413 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,510,820 - 40,517,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,510,820 - 40,517,821 (-)Ensemblpanpan1.1panPan2
MYCL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,975,757 - 3,019,313 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,006,409 - 3,013,381 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,171,121 - 3,271,536 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0153,000,940 - 3,101,940 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl153,001,007 - 3,101,936 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,907,962 - 3,008,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,967,859 - 3,068,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,984,277 - 3,085,131 (+)NCBIUU_Cfam_GSD_1.0
Mycl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505855,926,415 - 55,933,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,750,847 - 21,757,797 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,751,204 - 21,757,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYCL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,696,094 - 95,702,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1695,696,086 - 95,702,627 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,887,888 - 88,894,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mycl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,380,219 - 22,387,320 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,381,912 - 22,387,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1 1
Low 20 20 59
Below cutoff 15

Sequence


RefSeq Acc Id: ENSCSAT00000017395   ⟹   ENSCSAP00000016876
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2092,999,219 - 93,005,344 (+)Ensembl
RefSeq Acc Id: XM_007979290   ⟹   XP_007977481
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12092,998,668 - 93,005,283 (+)NCBI
Vero_WHO_p1.0NW_02366603323,836,433 - 23,843,547 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979291   ⟹   XP_007977482
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12092,998,885 - 93,005,283 (+)NCBI
Vero_WHO_p1.0NW_02366603323,836,433 - 23,843,302 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007977481 (Get FASTA)   NCBI Sequence Viewer  
  XP_007977482 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016876
  ENSCSAP00000016876.1
RefSeq Acc Id: XP_007977481   ⟸   XM_007979290
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007977482   ⟸   XM_007979291
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S7N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016876   ⟸   ENSCSAT00000017395


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001138 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017395.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Tscrpt_reg_Myc UniProtKB/TrEMBL
  Tscrpt_reg_Myc_N UniProtKB/TrEMBL
NCBI Gene MYCL ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/TrEMBL
  PROTEIN L-MYC-RELATED UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  Myc_N UniProtKB/TrEMBL
PIRSF Myc_protein UniProtKB/TrEMBL
PRINTS LEUZIPPRMYC UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A0D9S7N7 ENTREZGENE, UniProtKB/TrEMBL