SIRT4 (sirtuin 4) - Rat Genome Database

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Pathways
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Gene: SIRT4 (sirtuin 4) Chlorocebus sabaeus
Analyze
Symbol: SIRT4
Name: sirtuin 4
RGD ID: 18759943
Description: ENCODES a protein that exhibits NAD-dependent protein lysine deacetylase activity (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); negative regulation of cardiac muscle cell apoptotic process (ortholog); negative regulation of insulin secretion (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Cardiomegaly (ortholog); endomyocardial fibrosis (ortholog); genetic disease (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,640,976 - 115,659,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,640,555 - 115,658,687 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,447,251 - 129,463,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SIRT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,640,976 - 115,659,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,640,555 - 115,658,687 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,447,251 - 129,463,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SIRT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,291,780 - 120,313,249 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,302,316 - 120,313,249 (+)EnsemblGRCh38hg38GRCh38
GRCh3712120,729,583 - 120,751,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,224,546 - 119,235,428 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412119,202,882 - 119,213,764NCBI
Celera12120,373,255 - 120,384,162 (+)NCBICelera
Cytogenetic Map12q24.23-q24.31NCBI
HuRef12117,748,504 - 117,759,368 (+)NCBIHuRef
CHM1_112120,708,119 - 120,718,976 (+)NCBICHM1_1
T2T-CHM13v2.012120,277,808 - 120,300,434 (+)NCBIT2T-CHM13v2.0
Sirt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,616,065 - 115,628,322 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,616,069 - 115,622,784 (-)EnsemblGRCm39 Ensembl
GRCm385115,478,006 - 115,490,264 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,478,010 - 115,484,725 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,928,019 - 115,934,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,739,009 - 115,751,007 (-)NCBIMGSCv36mm8
Celera5112,577,219 - 112,584,001 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
Sirt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,785,852 - 46,800,179 (+)NCBIGRCr8
mRatBN7.21241,125,533 - 41,139,440 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,131,262 - 41,139,439 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,298,179 - 42,303,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,911,836 - 42,917,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,972,383 - 41,977,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,862,358 - 46,876,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,868,416 - 46,876,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,665,591 - 48,673,711 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,394,536 - 42,402,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,241,793 - 42,268,052 (+)NCBI
Celera1242,754,699 - 42,762,759 (+)NCBICelera
Cytogenetic Map12q16NCBI
Sirt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,324,479 - 11,334,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,322,812 - 11,334,786 (-)NCBIChiLan1.0ChiLan1.0
SIRT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,353,714 - 128,374,355 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,350,086 - 128,372,113 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,867,453 - 117,887,968 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,241,102 - 121,261,777 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,241,112 - 121,261,777 (+)Ensemblpanpan1.1panPan2
SIRT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,228,831 - 16,244,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,234,710 - 16,240,012 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,228,030 - 16,250,502 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,491,640 - 16,514,126 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,502,217 - 16,512,406 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,452,385 - 16,475,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,529,465 - 16,551,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,570,700 - 16,593,194 (+)NCBIUU_Cfam_GSD_1.0
Sirt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,129,984 - 146,134,550 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668626,938 - 633,466 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936668628,875 - 633,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,290,288 - 40,303,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,290,288 - 40,303,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,839,907 - 42,856,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sirt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,335,442 - 13,352,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,329,662 - 13,352,151 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 20 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000000287   ⟹   ENSCSAP00000015768
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11115,640,555 - 115,658,687 (+)Ensembl
RefSeq Acc Id: XM_008004929   ⟹   XP_008003120
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111115,651,217 - 115,658,898 (+)NCBI
Vero_WHO_p1.0NW_023666037129,447,452 - 129,455,116 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004930   ⟹   XP_008003121
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111115,640,976 - 115,658,898 (+)NCBI
Vero_WHO_p1.0NW_023666037129,447,452 - 129,463,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004931   ⟹   XP_008003122
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111115,640,976 - 115,658,898 (+)NCBI
Vero_WHO_p1.0NW_023666037129,447,452 - 129,463,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004932   ⟹   XP_008003123
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111115,651,217 - 115,658,898 (+)NCBI
Vero_WHO_p1.0NW_023666037129,447,452 - 129,455,118 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037996287   ⟹   XP_037852215
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037129,447,452 - 129,455,119 (-)NCBI
RefSeq Acc Id: XR_499475
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111115,651,217 - 115,659,074 (+)NCBI
Vero_WHO_p1.0NW_023666037129,447,251 - 129,455,116 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_008003121   ⟸   XM_008004930
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S4H9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008003122   ⟸   XM_008004931
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S4H9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008003120   ⟸   XM_008004929
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008003123   ⟸   XM_008004932
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCSAP00000015768   ⟸   ENSCSAT00000000287
RefSeq Acc Id: XP_037852215   ⟸   XM_037996287
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000287.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Sirtuin_class_II UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
NCBI Gene SIRT4 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A0D9S4H9 ENTREZGENE, UniProtKB/TrEMBL