MEP1A (meprin A subunit alpha) - Rat Genome Database

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Gene: MEP1A (meprin A subunit alpha) Chlorocebus sabaeus
Analyze
Symbol: MEP1A
Name: meprin A subunit alpha
RGD ID: 18754594
Description: ENCODES a protein that exhibits metal ion binding (inferred); metallodipeptidase activity (inferred); metalloendopeptidase activity (inferred); INVOLVED IN epidermal growth factor receptor ligand maturation (inferred); proteolysis (inferred); signaling receptor ligand precursor processing (inferred); ASSOCIATED WITH Colonic Neoplasms (ortholog); genetic disease (ortholog); FOUND IN meprin A complex (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,439,415 - 25,479,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,439,442 - 25,473,681 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,813,671 - 46,854,220 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
meprin A complex  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MEP1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,439,415 - 25,479,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,439,442 - 25,473,681 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,813,671 - 46,854,220 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MEP1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,793,389 - 46,845,984 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,793,389 - 46,839,778 (+)EnsemblGRCh38hg38GRCh38
GRCh37646,761,126 - 46,807,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,869,053 - 46,915,478 (+)NCBINCBI36Build 36hg18NCBI36
Build 34646,869,085 - 46,915,473NCBI
Celera648,313,551 - 48,359,899 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,484,757 - 46,530,783 (+)NCBIHuRef
CHM1_1646,764,471 - 46,810,789 (+)NCBICHM1_1
T2T-CHM13v2.0646,631,036 - 46,683,461 (+)NCBIT2T-CHM13v2.0
Mep1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,785,215 - 43,815,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,785,215 - 43,813,703 (-)EnsemblGRCm39 Ensembl
GRCm381743,474,324 - 43,504,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,474,324 - 43,502,812 (-)EnsemblGRCm38mm10GRCm38
MGSCv371743,611,278 - 43,639,722 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,938,373 - 42,967,156 (-)NCBIMGSCv36mm8
Celera1746,896,845 - 46,925,249 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.73NCBI
Mep1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,971,901 - 25,001,414 (+)NCBIGRCr8
mRatBN7.2917,474,634 - 17,504,147 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,474,619 - 17,504,147 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,065,182 - 26,095,281 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,139,752 - 31,169,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0929,428,977 - 29,459,076 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,048,163 - 20,077,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,048,121 - 20,077,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,925,181 - 18,953,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,170,762 - 13,201,094 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,168,083 - 13,198,416 (+)NCBI
Celera915,197,113 - 15,224,494 (+)NCBICelera
Cytogenetic Map9q13NCBI
Mep1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543711,602,113 - 11,636,144 (+)NCBIChiLan1.0ChiLan1.0
MEP1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,294,694 - 61,337,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,160,890 - 57,204,126 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0646,382,105 - 46,425,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,647,721 - 47,690,331 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,647,721 - 47,691,070 (+)Ensemblpanpan1.1panPan2
MEP1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,966,215 - 15,004,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,966,209 - 15,003,867 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,997,039 - 15,035,329 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,465,854 - 15,500,412 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,465,839 - 15,500,421 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,981,007 - 15,015,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,070,190 - 15,108,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,216,475 - 15,254,182 (+)NCBIUU_Cfam_GSD_1.0
Mep1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,406,962 - 50,445,654 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647613,514,965 - 13,553,209 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEP1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1741,587,698 - 41,625,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,248,938 - 48,286,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mep1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475413,845,949 - 13,865,792 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 1 12 1
Below cutoff 15 5 34

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007972329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000010693   ⟹   ENSCSAP00000008782
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1725,439,442 - 25,473,681 (-)Ensembl
RefSeq Acc Id: XM_007972329   ⟹   XP_007970520
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11725,439,415 - 25,479,092 (-)NCBI
Vero_WHO_p1.0NW_02366604446,813,671 - 46,854,220 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007970520 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008782.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970520   ⟸   XM_007972329
- UniProtKB: A0A0D9RJJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008782   ⟸   ENSCSAT00000010693


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010693.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  MATH/TRAF_dom UniProtKB/TrEMBL
  Meprin UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  TRAF_MEP1_MATH_dom UniProtKB/TrEMBL
NCBI Gene MEP1A ENTREZGENE
PANTHER DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
  PTHR10127:SF824 UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  TRAF-mep_MATH UniProtKB/TrEMBL
PIRSF Meprin UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
  MAMDOMAIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
SMART MAM UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A0D9RJJ3 ENTREZGENE, UniProtKB/TrEMBL