RHOT1 (ras homolog family member T1) - Rat Genome Database

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Gene: RHOT1 (ras homolog family member T1) Chlorocebus sabaeus
Analyze
Symbol: RHOT1
Name: ras homolog family member T1
RGD ID: 18746299
Description: ENCODES a protein that exhibits calcium ion binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN establishment of mitochondrion localization by microtubule attachment (ortholog); regulation of neurotransmitter secretion (ortholog); regulation of organelle transport along microtubule (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH genetic disease (ortholog); motor neuron disease (ortholog); FOUND IN mitochondrial outer membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103242688; mitochondrial Rho GTPase 1; uncharacterized LOC103242688
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,720,640 - 25,798,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,750,224 - 25,799,286 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660754,223,088 - 4,335,457 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RHOT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,720,640 - 25,798,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,750,224 - 25,799,286 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660754,223,088 - 4,335,457 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RHOT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381732,142,502 - 32,225,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1732,142,454 - 32,253,374 (+)EnsemblGRCh38hg38GRCh38
GRCh371730,469,521 - 30,552,746 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,493,586 - 27,576,859 (+)NCBINCBI36Build 36hg18NCBI36
Build 341727,493,761 - 27,560,869NCBI
Celera1727,380,006 - 27,463,684 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,657,489 - 26,740,675 (+)NCBIHuRef
CHM1_11730,531,938 - 30,615,232 (+)NCBICHM1_1
T2T-CHM13v2.01733,088,266 - 33,171,497 (+)NCBIT2T-CHM13v2.0
Rhot1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,099,844 - 80,158,736 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,099,845 - 80,158,733 (+)EnsemblGRCm39 Ensembl
GRCm381180,208,610 - 80,267,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,209,019 - 80,267,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv371180,022,557 - 80,081,409 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361180,025,279 - 80,083,681 (+)NCBIMGSCv36mm8
Celera1189,845,510 - 89,904,362 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.62NCBI
Rhot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,685,687 - 65,760,682 (+)NCBIGRCr8
mRatBN7.21065,198,700 - 65,262,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1065,170,560 - 65,262,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1069,827,575 - 69,891,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01069,332,879 - 69,396,564 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01064,796,754 - 64,860,391 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01067,559,277 - 67,640,622 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,532,030 - 67,640,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01067,216,636 - 67,297,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41068,423,410 - 68,488,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11068,437,002 - 68,502,001 (+)NCBI
Celera1064,160,374 - 64,223,357 (+)NCBICelera
Cytogenetic Map10q25-q26NCBI
Rhot1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554817,149,241 - 7,199,296 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554817,149,836 - 7,199,296 (+)NCBIChiLan1.0ChiLan1.0
RHOT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21932,204,125 - 32,314,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11734,084,079 - 34,194,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,523,047 - 24,633,559 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11724,837,093 - 24,917,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1724,837,093 - 24,917,310 (-)Ensemblpanpan1.1panPan2
RHOT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1940,715,713 - 40,779,551 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl940,715,941 - 40,779,400 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha939,874,695 - 39,938,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0941,532,523 - 41,596,217 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,532,525 - 41,596,190 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,318,018 - 40,381,819 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,612,413 - 40,676,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0940,687,227 - 40,750,891 (-)NCBIUU_Cfam_GSD_1.0
Rhot1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560239,780,322 - 39,847,949 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365382,658,172 - 2,726,092 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365382,658,225 - 2,725,889 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,711,233 - 42,783,421 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,711,231 - 42,783,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,443,398 - 44,515,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Rhot1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624875242,550 - 311,871 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000004466   ⟹   ENSCSAP00000002719
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1625,750,224 - 25,799,286 (+)Ensembl
RefSeq Acc Id: XM_037992531   ⟹   XP_037848459
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,247,518 - 4,335,457 (-)NCBI
RefSeq Acc Id: XM_037992532   ⟹   XP_037848460
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,223,088 - 4,335,423 (-)NCBI
RefSeq Acc Id: XM_037992533   ⟹   XP_037848461
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,260,636 - 4,335,423 (-)NCBI
RefSeq Acc Id: XM_037992534   ⟹   XP_037848462
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,247,518 - 4,335,430 (-)NCBI
RefSeq Acc Id: XM_037992535   ⟹   XP_037848463
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,247,518 - 4,301,645 (-)NCBI
RefSeq Acc Id: XM_037992536   ⟹   XP_037848464
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,247,518 - 4,335,457 (-)NCBI
RefSeq Acc Id: XM_037992537   ⟹   XP_037848465
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,223,088 - 4,335,423 (-)NCBI
RefSeq Acc Id: XM_037992538   ⟹   XP_037848466
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660754,247,518 - 4,335,430 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000002719   ⟸   ENSCSAT00000004466
RefSeq Acc Id: XP_037848465   ⟸   XM_037992537
- Peptide Label: isoform X7
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848460   ⟸   XM_037992532
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848464   ⟸   XM_037992536
- Peptide Label: isoform X6
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848459   ⟸   XM_037992531
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848466   ⟸   XM_037992538
- Peptide Label: isoform X8
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848462   ⟸   XM_037992534
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848463   ⟸   XM_037992535
- Peptide Label: isoform X5
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848461   ⟸   XM_037992533
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R280 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004466.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_assoc_1 UniProtKB/TrEMBL
  EF_hand_assoc_2 UniProtKB/TrEMBL
  Miro UniProtKB/TrEMBL
  MIRO_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
NCBI Gene RHOT1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
Pfam EF_assoc_1 UniProtKB/TrEMBL
  EF_assoc_2 UniProtKB/TrEMBL
  Ras UniProtKB/TrEMBL
PIRSF Mt_Rho_GTPase UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  MIRO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9R280 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 RHOT1  ras homolog family member T1  LOC103242688  uncharacterized LOC103242688  Data merged from RGD:18731608 737654 PROVISIONAL